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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1lnyIMOAdenylosuccinate synthetase isozyme 1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1lnyIMOAdenylosuccinate synthetase isozyme 1/1.000
1p9bIMOAdenylosuccinate synthetase/0.494
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.491
1ijjLARActin, alpha skeletal muscle/0.479
1qf4RPDAdenylosuccinate synthetase/0.477
4f9fGDPPutative glycosyltransferase/0.477
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.477
1nhtPGSAdenylosuccinate synthetase/0.476
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.475
1cg0IMOAdenylosuccinate synthetase/0.473
1cg4IMOAdenylosuccinate synthetase/0.470
2yyiFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.468
2d4vNADIsocitrate dehydrogenase [NADP]/0.467
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.467
4dfg0JVGag-Pol polyprotein3.4.23.160.466
1tj0FADBifunctional protein PutA1.5.5.20.464
3sj7NDP3-oxoacyl-(Acyl-carrier-protein) reductase, putative/0.464
4l435FIRibosomal protein S6 kinase beta-12.7.11.10.463
1phhFADp-hydroxybenzoate hydroxylase/0.462
4xsvC5PEthanolamine-phosphate cytidylyltransferase2.7.7.140.462
3hdyFADUDP-galactopyranose mutase/0.461
4iqlFMNEnoyl-(Acyl-carrier-protein) reductase II/0.461
2yyuC5POrotidine 5'-phosphate decarboxylase/0.459
3fhxPLPPyridoxal kinase2.7.1.350.459
3bv2P38Mitogen-activated protein kinase 14/0.458
3e2sFADBifunctional protein PutA1.5.5.20.458
2c29NAPDihydroflavonol 4-reductase/0.457
2wmvZYVSerine/threonine-protein kinase Chk12.7.11.10.456
4tm4FDAKtzI/0.456
2gstGPSGlutathione S-transferase Mu 12.5.1.180.455
3p62FMNPentaerythritol tetranitrate reductase/0.455
3wmxNADNAD dependent epimerase/dehydratase/0.455
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.455
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.454
4gh5NADShort-chain dehydrogenase/reductase SDR/0.454
1rdwLARActin, alpha skeletal muscle/0.453
2vo7M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.453
4eu9COASuccinyl-CoA:acetate CoA-transferase/0.453
2p5uNADUDP-glucose 4-epimerase/0.452
5c8wPCGcGMP-dependent protein kinase 22.7.11.120.452
2fzmFADBifunctional protein PutA1.5.5.20.451
3d3wNAPL-xylulose reductase1.1.1.100.451
4bfvZVVPantothenate kinase2.7.1.330.451
4ftq4HKSerine/threonine-protein kinase Chk12.7.11.10.451
1kvkATPMevalonate kinase2.7.1.360.450
1nlmUD1UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase/0.450
1udyFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.450
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.450
1npvL27Gag-Pol polyprotein3.4.23.160.449
1pd9CO4Dihydrofolate reductase1.5.1.30.449
1cg1IMOAdenylosuccinate synthetase/0.448
1u8vFAD4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase/0.448
3gbuATPUncharacterized sugar kinase PH14592.7.10.448
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
1osvCHCBile acid receptor/0.447
1w7h3IPMitogen-activated protein kinase 14/0.447
2npxNADNADH peroxidase1.11.1.10.447
3i59N6RCRP-like cAMP-activated global transcriptional regulator/0.447
3lqfNADGalactitol dehydrogenase/0.447
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.447
3wfjNAD2-dehydropantoate 2-reductase/0.447
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.447
1rfqLARActin, alpha skeletal muscle/0.446
2ebaFADPutative glutaryl-CoA dehydrogenase/0.446
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.446
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.446
3kjrNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.446
4i02CMPcAMP-activated global transcriptional regulator CRP/0.446
1adfTADAlcohol dehydrogenase E chain1.1.1.10.445
1vyrFMNPentaerythritol tetranitrate reductase/0.445
1xddAAYIntegrin alpha-L/0.445
2cgv3B3Serine/threonine-protein kinase Chk12.7.11.10.445
2y8qADP5'-AMP-activated protein kinase subunit gamma-1/0.445
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.445
3kb1ADPIron-sulfur cluster carrier protein/0.445
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.445
4h2nFAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase/0.445
4i1nFOLDihydrofolate reductase1.5.1.30.445
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.445
2gnaGDUUDP-N-acetylglucosamine 4,6-dehydratase (inverting)4.2.1.1150.444
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.444
2q7vFADThioredoxin reductase/0.444
2xf04UBSerine/threonine-protein kinase Chk12.7.11.10.444
3rk1ATPN-type ATP pyrophosphatase superfamily/0.444
1i2lDCSAminodeoxychorismate lyase4.1.3.380.443
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.443
3b895GP16S rRNA methylase/0.443
3he3FADUDP-galactopyranose mutase/0.443
3ukuC69Actin-related protein 3/0.443
4ejmNAPPutative zinc-binding dehydrogenase/0.443
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.443
5f8eSAHPossible transcriptional regulatory protein/0.443
1esvLARActin, alpha skeletal muscle/0.442
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.442
3b2eADPATPase GET3/0.442
3o03NAPDehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase)/0.442
1a72PADAlcohol dehydrogenase E chain1.1.1.10.441
1sq5ADPPantothenate kinase2.7.1.330.441
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.441
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.441
3v5w8PRBeta-adrenergic receptor kinase 12.7.11.150.441
3w32W32Epidermal growth factor receptor2.7.10.10.441
4bb3KKAIsopenicillin N synthase1.21.3.10.441
4o1mNADEnoyl-acyl carrier reductase/0.441
5a3bAPRSIR2 family protein/0.441
1bdlIM1Gag-Pol polyprotein3.4.23.160.440
1bwsNDPGDP-L-fucose synthase/0.440
1u1iNADMyo-inositol-1-phosphate synthase (Ino1)/0.440
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.440
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.440
3r9uFADThioredoxin reductase/0.440
3uozFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.440
4a99FADTetX family tetracycline inactivation enzyme/0.440
4dpwAGSMevalonate diphosphate decarboxylase/0.440
4i1iNADMalate dehydrogenase/0.440
4y9lFADAcyl-CoA dehydrogenase family member 11/0.440