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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1jtvTESEstradiol 17-beta-dehydrogenase 11.1.1.62

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1jtvTESEstradiol 17-beta-dehydrogenase 11.1.1.621.000
1qyxASDEstradiol 17-beta-dehydrogenase 11.1.1.620.668
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.603
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.579
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.573
1qyw5SDEstradiol 17-beta-dehydrogenase 11.1.1.620.524
1fdwESTEstradiol 17-beta-dehydrogenase 11.1.1.620.498
1fdsESTEstradiol 17-beta-dehydrogenase 11.1.1.620.490
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.487
1fdtESTEstradiol 17-beta-dehydrogenase 11.1.1.620.479
3deyDHTEstradiol 17-beta-dehydrogenase 11.1.1.620.476
3klmDHTEstradiol 17-beta-dehydrogenase 11.1.1.620.476
3lqfNADGalactitol dehydrogenase/0.474
4yaoFMNNADPH--cytochrome P450 reductase/0.472
4m9aFDAAcyl-CoA dehydrogenase/0.471
5dcyNAPIridoid synthase1.3.1.990.471
5dp2NAPCurF/0.468
2xlrFADPutative flavin-containing monooxygenase/0.466
2ejvNADL-threonine 3-dehydrogenase/0.465
1fmlRTLRetinol dehydratase/0.464
4uwmFMN3,6-diketocamphane 1,6 monooxygenase1.14.130.462
3ukoNADAlcohol dehydrogenase class-3/0.461
3oqkS52Renin3.4.23.150.460
1bxkNADdTDP-glucose 4,6-dehydratase 2/0.459
3f63GTXGlutathione transferase GST1-4/0.459
4bfxZVXPantothenate kinase2.7.1.330.459
3toxNAPPutative oxidoreductase/0.458
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.458
2geuCOKPantothenate kinase2.7.1.330.457
4dbzNDPPutative ketoacyl reductase1.3.10.457
5hs1VORLanosterol 14-alpha demethylase/0.457
4bcaFADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.456
4kbyC2EStimulator of interferon genes protein/0.456
1u7tNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.455
1x8lOXRRetinol dehydratase/0.455
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.455
1xe55FEPlasmepsin-23.4.23.390.454
4bc7FADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.454
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.454
3frkTQPQdtB/0.452
1z7yAA5Cysteine synthase 12.5.1.470.451
2g8yNADHydroxycarboxylate dehydrogenase B/0.451
3f03FMNPentaerythritol tetranitrate reductase/0.451
2d29FADAcyl-CoA dehydrogenase/0.450
2gv8NDPThiol-specific monooxygenase1.14.130.450
2iko7IGRenin3.4.23.150.450
2v6gNAP3-oxo-Delta(4,5)-steroid 5-beta-reductase/0.450
3oqfS51Renin3.4.23.150.450
3p62FMNPentaerythritol tetranitrate reductase/0.450
1culFOKAdenylate cyclase type 2/0.449
1culFOKAdenylate cyclase type 5/0.449
4rvgTYDD-mycarose 3-C-methyltransferase/0.449
1lwiNAP3-alpha-hydroxysteroid dehydrogenase1.1.1.500.448
1tehNADAlcohol dehydrogenase class-31.1.1.10.448
2ok7FADFerredoxin--NADP reductase, apicoplast/0.448
3p8jFMNPentaerythritol tetranitrate reductase/0.448
4bfvZVVPantothenate kinase2.7.1.330.448
4gl4NAIAlcohol dehydrogenase class-3/0.448
4wuoNAD3-isopropylmalate dehydrogenase1.1.1.850.448
5dbfNDPIridoid synthase1.3.1.990.448
1rneC60Renin3.4.23.150.446
2il2LIXRenin3.4.23.150.446
4q71FADBifunctional protein PutA/0.446
5jscFADPutative acyl-CoA dehydrogenase/0.446
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.445
3zw9NADPeroxisomal bifunctional enzyme1.1.1.350.445
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.445
5a3bAPRSIR2 family protein/0.445
1bygSTUTyrosine-protein kinase CSK/0.444
4bbyFADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.444
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.444
1bwsNDPGDP-L-fucose synthase/0.443
1h74ADPHomoserine kinase2.7.1.390.443
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.443
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.443
3nmpPYVAbscisic acid receptor PYL2/0.443
3vqsJT1Genome polyprotein/0.443
4dc0NDPPutative ketoacyl reductase1.3.10.443
4xrgNADHomospermidine synthase2.5.1.440.443
1e3eNAIAlcohol dehydrogenase 41.1.1.10.442
1equEQIEstradiol 17-beta-dehydrogenase 11.1.1.620.442
1h73ANPHomoserine kinase2.7.1.390.442
1wn3HXCPhenylacetic acid degradation protein PaaI/0.442
2xviFADPutative flavin-containing monooxygenase/0.442
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.442
3gfbNADL-threonine 3-dehydrogenase/0.442
4xguADPPutative pachytene checkpoint protein 2/0.442
1k7fIAVTryptophan synthase alpha chain/0.441
1pqc444Oxysterols receptor LXR-beta/0.441
2igoFADPyranose 2-oxidase/0.441
2qimZEAClass 10 plant pathogenesis-related protein/0.441
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.441
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.441
1mp0NADAlcohol dehydrogenase class-31.1.1.10.440
2ikuLIYRenin3.4.23.150.440
2oapANPType II secretion system protein (GspE-2)/0.440
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.440
4f7iNAD3-isopropylmalate dehydrogenase1.1.1.850.440