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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1jkkANPDeath-associated protein kinase 12.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1jkkANPDeath-associated protein kinase 12.7.11.11.000
1ig1ANPDeath-associated protein kinase 12.7.11.10.748
1jklANPDeath-associated protein kinase 12.7.11.10.728
2w4jADPDeath-associated protein kinase 12.7.11.10.656
3gu7ADPDeath-associated protein kinase 12.7.11.10.612
4qnyANPMitogen activated protein kinase, putative/0.574
3bu5ATPInsulin receptor2.7.10.10.536
4ysjADPCalmodulin-like domain protein kinase/0.527
2yaaATPDeath-associated protein kinase 2/0.526
5dosATPAurora kinase A2.7.11.10.518
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.516
4xlvACPInsulin receptor2.7.10.10.511
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.508
3c4zADPRhodopsin kinase/0.504
4eooATPCyclin-dependent kinase 22.7.11.220.499
3c4wATPRhodopsin kinase/0.495
5av3KMPDeath-associated protein kinase 12.7.11.10.495
2j0lANPFocal adhesion kinase 12.7.10.20.490
3dqwAGSProto-oncogene tyrosine-protein kinase Src2.7.10.20.486
4ii5ADPCyclin-dependent kinase 22.7.11.220.484
5av2KMPDeath-associated protein kinase 12.7.11.10.483
1mruAGSSerine/threonine-protein kinase PknB2.7.11.10.481
3orpAGSSerine/threonine protein kinase/0.479
3qc9ADPRhodopsin kinase/0.479
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.479
3lltANPProtein serine/threonine kinase-1/0.478
3zxtACPDeath-associated protein kinase 12.7.11.10.477
5dnrATPAurora kinase A2.7.11.10.475
2cjmATPCyclin-dependent kinase 22.7.11.220.473
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.472
4i3zADPCyclin-dependent kinase 22.7.11.220.472
4s33ANPMitogen-activated protein kinase 12.7.11.240.472
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.472
3c4xATPRhodopsin kinase/0.470
1qmzATPCyclin-dependent kinase 22.7.11.220.469
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.469
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.469
4c3pACPAurora kinase A2.7.11.10.466
1bx6BA1cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.465
5eg3ACPFibroblast growth factor receptor 2/0.463
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.462
2ijmADPFocal adhesion kinase 12.7.10.20.460
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.459
4crsAGSSerine/threonine-protein kinase N22.7.11.130.459
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.458
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.458
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.457
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.455
4jbpYPHAurora kinase A2.7.11.10.455
2vrx447Aurora kinase B-A2.7.11.10.454
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.453
4qmlANPSerine/threonine-protein kinase 242.7.11.10.453
3dfcANPDeath-associated protein kinase 12.7.11.10.449
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.448
1vebI05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
4deeADPAurora kinase A2.7.11.10.447
5cvfATPCasein kinase II subunit alpha2.7.11.10.446
4e4n0NLTyrosine-protein kinase JAK1/0.444
3i60E86Mitogen-activated protein kinase 12.7.11.240.442
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.442
4jrnANPRhoptry kinase family protein/0.442
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.441
3ortAGSSerine/threonine protein kinase/0.441
3w2sW2REpidermal growth factor receptor2.7.10.10.441