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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1feaFADTrypanothione reductase1.8.1.12

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1feaFADTrypanothione reductase1.8.1.121.000
1febFADTrypanothione reductase1.8.1.120.610
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.568
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.565
1gerFADGlutathione reductase1.8.1.70.560
2gh5FADGlutathione reductase, mitochondrial1.8.1.70.554
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.548
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.545
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.545
1grhFADGlutathione reductase, mitochondrial1.8.1.70.543
3sqpFADGlutathione reductase, mitochondrial1.8.1.70.535
1bwcFADGlutathione reductase, mitochondrial1.8.1.70.530
3dk8FADGlutathione reductase, mitochondrial1.8.1.70.529
3grsFADGlutathione reductase, mitochondrial1.8.1.70.528
1graFADGlutathione reductase, mitochondrial1.8.1.70.527
4jq9FADDihydrolipoyl dehydrogenase/0.526
1greFADGlutathione reductase, mitochondrial1.8.1.70.524
1grgFADGlutathione reductase, mitochondrial1.8.1.70.523
4nevFADTrypanothione reductase/0.517
2v6oFADThioredoxin glutathione reductase/0.516
1gsnFADGlutathione reductase, mitochondrial1.8.1.70.515
1h6vFADThioredoxin reductase 1, cytoplasmic1.8.1.90.515
3dk9FADGlutathione reductase, mitochondrial1.8.1.70.514
2cfyFADThioredoxin reductase 1, cytoplasmic1.8.1.90.513
2r9zFADGlutathione amide reductase/0.513
3dgzFADThioredoxin reductase 2, mitochondrial1.8.1.90.513
1bzlFADTrypanothione reductase1.8.1.120.511
3dk4FADGlutathione reductase, mitochondrial1.8.1.70.506
1geuFADGlutathione reductase1.8.1.70.498
2nvkFADThioredoxin reductase 1, mitochondrial1.8.1.90.494
2eq9FADDihydrolipoyl dehydrogenase/0.489
1zx9FADMercuric reductase1.16.1.10.481
1zk7FADMercuric reductase1.16.1.10.473
2eq8FADDihydrolipoyl dehydrogenase/0.472
1lvlFADDihydrolipoyl dehydrogenase1.8.1.40.471
4jdrFADDihydrolipoyl dehydrogenase1.8.1.40.470
2rabFADGlutathione amide reductase/0.462
2yquFADDihydrolipoyl dehydrogenase/0.459
3urhFADDihydrolipoyl dehydrogenase/0.457
3djgFADGlutathione reductase, mitochondrial1.8.1.70.456
1lpfFADDihydrolipoyl dehydrogenase1.8.1.40.455
3ic9FADPutative dihydrolipoamide dehydrogenase/0.454
4j56FADThioredoxin reductase 21.8.1.90.454
1nhpFADNADH peroxidase1.11.1.10.451
3icrFADCoenzyme A disulfide reductase/0.451
1onfFADGlutathione reductase1.8.1.70.448
3cgcFADCoenzyme A disulfide reductase/0.447
1grbFADGlutathione reductase, mitochondrial1.8.1.70.446
3nt6FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase/0.446
2qaeFADDihydrolipoyl dehydrogenase1.8.1.40.445
1mokFAD2-oxopropyl-CoM reductase, carboxylating1.8.1.50.444
1zmcFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.443
1jehFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.442
2a8xFADDihydrolipoyl dehydrogenase1.8.1.40.441
4emwFADCoenzyme A disulfide reductase/0.441
1getFADGlutathione reductase1.8.1.70.440
2hqmFADGlutathione reductase1.8.1.70.440