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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1enzNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.9

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1enzNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.91.000
1enyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.666
2aqkNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.614
2aqhNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.601
4dreNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.600
3of2NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.590
3oewNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.589
4dtiNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.589
2aqiNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.583
2nv6ZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.571
4dquNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.565
3oeyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.554
2idzZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.551
5cpbNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.551
2aq8NAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.548
2ntvP1HEnoyl-[acyl-carrier-protein] reductase [NADH]/0.536
4bgiI4IEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.536
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.532
2ie0ZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.527
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.526
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.525
1zidZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.521
4trnNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.521
1p44NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.520
4zjuNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.520
2iebZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.518
4bqpNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.514
2h9iEADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.513
3th8TH9Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.503
3g5hYTTMycocyclosin synthase1.14.21.90.498
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.498
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.496
4oxyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.495
5koiNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.491
4ipw1G7Mycocyclosin synthase1.14.21.90.489
2ntjP1HEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.488
2b36NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.478
2jn3JN3Fatty acid-binding protein, liver/0.477
2qo4CHDFatty acid-binding protein 10-A, liver basic/0.477
4g1z0VPVitamin D3 receptor A/0.476
4r20AERCytochrome P450 family 17 polypeptide 2/0.475
2qo6CHDFatty acid-binding protein 10-A, liver basic/0.473
2vn0TDZCytochrome P450 2C8/0.473
2b35NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.472
1eupASD6-deoxyerythronolide B hydroxylase/0.470
1jipKTN6-deoxyerythronolide B hydroxylase/0.465
1jioDEB6-deoxyerythronolide B hydroxylase/0.463
4e5yNDPGDP-L-fucose synthase1.1.1.2710.461
4ips1G4Mycocyclosin synthase1.14.21.90.461
4k5sPM0Oxygenase/0.459
2hw2RFPRifampin ADP-ribosyl transferase/0.457
4k9v6AWCytochrome P450 3A4/0.457
3nxuRITCytochrome P450 3A4/0.456
4bgiNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.456
1e7qNAPGDP-L-fucose synthase/0.455
2hwrDRDPeroxisome proliferator-activated receptor gamma/0.455
3vt65YIVitamin D3 receptor/0.454
3umvFADDeoxyribodipyrimidine photo-lyase4.1.99.30.453
4ktkKTKCytochrome P450/0.453
1tw4CHDFatty acid-binding protein, liver/0.451
2zbaZBATrichothecene 3-O-acetyltransferase/0.450
4h9753SDihydrofolate reductase1.5.1.30.449
4rlh0WEEnoyl-[acyl-carrier-protein] reductase [NADH]/0.449
1m7aMQUDihydrofolate reductase1.5.1.30.448
2vxoXMPGMP synthase [glutamine-hydrolyzing]6.3.5.20.448
5bsfNADPyrroline-5-carboxylate reductase/0.448
4ia7BIVVitamin D3 receptor A/0.447
1ez4NADL-lactate dehydrogenase1.1.1.270.446
3cgeNDPCoenzyme A disulfide reductase/0.446
4nkvAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.446
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.445
3nr4PYVAbscisic acid receptor PYL2/0.445
5akk1P8Bifunctional epoxide hydrolase 23.1.3.760.445
3gobHXXDdmC/0.444
3qlwN22Dihydrofolate reductase1.5.1.30.444
3wecAUICytochrome P450/0.444
1rkhVD2Vitamin D3 receptor/0.443
2j0dERYCytochrome P450 3A4/0.443
2ovhAS0Progesterone receptor/0.443
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.443
3dhoB2MStreptogramin A acetyltransferase2.3.10.443
4iteTEYVitamin D3 receptor/0.443
4iui1GQEstrogen receptor/0.443
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.443
4z63ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.443
5irnADPNucleotide binding oligomerization domain containing 2/0.443
1ie9VDXVitamin D3 receptor/0.442
1kkq471Peroxisome proliferator-activated receptor alpha/0.442
1lsjNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.442
1zeoC01Peroxisome proliferator-activated receptor gamma/0.442
2hcdBIVVitamin D3 receptor A/0.442
2y3rTRKTamL/0.442
3vrwYS5Vitamin D3 receptor/0.442
4fjz4FJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4itmATPTetraacyldisaccharide 4'-kinase/0.442
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.441
3frqERYErythromycin resistance repressor protein/0.441
3s79ASDAromatase1.14.14.140.441
4q72FADBifunctional protein PutA/0.441
1uy7PU4Heat shock protein HSP 90-alpha/0.440
2cy0NAPShikimate dehydrogenase (NADP(+))/0.440
2hb7O1CVitamin D3 receptor/0.440
4jvb1M0Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.440