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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1e7wMTXPteridine reductase 11.5.1.33

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1e7wMTXPteridine reductase 11.5.1.331.000
2yhuWHFPteridine reductase/0.523
3jqbDX6Pteridine reductase, putative/0.521
3jq8DX3Pteridine reductase, putative/0.506
3jq7DX2Pteridine reductase, putative/0.505
1p33MTXPteridine reductase 11.5.1.330.503
3jqgAX6Pteridine reductase, putative/0.503
3jq9AX1Pteridine reductase, putative/0.502
2bfpH4BPteridine reductase 11.5.1.330.501
3bmqAX5Pteridine reductase/0.499
2vz0D64Pteridine reductase/0.496
2x9vTMQPteridine reductase/0.491
3h4vDVPPteridine reductase 11.5.1.330.491
3bmcFOLPteridine reductase/0.490
2bf7HBIPteridine reductase 11.5.1.330.488
2wd7VGDPteridine reductase/0.487
2bfmTOPPteridine reductase 11.5.1.330.485
1mxfMTXPutative pteridine reductase 2/0.474
3bmnAX3Pteridine reductase/0.471
2x9gLYAPteridine reductase/0.467
1e92HBIPteridine reductase 11.5.1.330.463
3jq6DX1Pteridine reductase, putative/0.452
2bfaCB3Pteridine reductase 11.5.1.330.451
4f0fACPProbable serine/threonine-protein kinase roco42.7.11.10.447
4f1mACPProbable serine/threonine-protein kinase roco42.7.11.10.446
2x9nAX3Pteridine reductase/0.441
2cleF6FTryptophan synthase alpha chain/0.440