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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1bwsNDPGDP-L-fucose synthase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1bwsNDPGDP-L-fucose synthase/1.000
1e7qNAPGDP-L-fucose synthase/0.578
1fxsNAPGDP-L-fucose synthase/0.547
1bsvNDPGDP-L-fucose synthase/0.545
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.490
4b8wNAPGDP-L-fucose synthase1.1.1.2710.488
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.486
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.486
4b8zNAPGDP-L-fucose synthase1.1.1.2710.480
3f03FMNPentaerythritol tetranitrate reductase/0.476
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.476
4e5yNDPGDP-L-fucose synthase1.1.1.2710.476
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.475
3gfbNADL-threonine 3-dehydrogenase/0.471
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.469
1dirNADDihydropteridine reductase1.5.1.340.468
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.467
3a1nNADNDP-sugar epimerase/0.464
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.463
1hdrNADDihydropteridine reductase1.5.1.340.462
3orfNADDihydropteridine reductase1.5.1.340.462
4q71FADBifunctional protein PutA/0.462
4uymVOR14-alpha sterol demethylase Cyp51B/0.462
2hs8FMN12-oxophytodienoate reductase 31.3.1.420.461
3rudNADUDP-N-acetylglucosamine 4-epimerase/0.460
4hbm0Y7E3 ubiquitin-protein ligase Mdm26.3.20.460
4u7wNDPMxaA/0.460
2hunNAD336aa long hypothetical dTDP-glucose 4,6-dehydratase/0.459
2uxoTACHTH-type transcriptional regulator TtgR/0.459
4jicFMNGTN Reductase/0.459
1kkq471Peroxisome proliferator-activated receptor alpha/0.458
1nzdUPGDNA beta-glucosyltransferase/0.458
4g9kFADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.458
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.456
1n2sNAIdTDP-4-dehydrorhamnose reductase1.1.1.1330.456
3enkUPGUDP-glucose 4-epimerase/0.456
3slkNDPPolyketide synthase extender module 2/0.456
1h50FMNPentaerythritol tetranitrate reductase/0.454
3a4vNADNDP-sugar epimerase/0.454
1h51FMNPentaerythritol tetranitrate reductase/0.453
4egbNADdTDP-glucose 4,6-dehydratase/0.453
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.452
3atyFMNProstaglandin F2a synthase/0.451
3p82FMNPentaerythritol tetranitrate reductase/0.451
3ru7NADUDP-N-acetylglucosamine 4-epimerase/0.451
3rucNADUDP-N-acetylglucosamine 4-epimerase/0.451
1w6hTITPlasmepsin-23.4.23.390.450
2p5uNADUDP-glucose 4-epimerase/0.450
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
3eheNADUDP-glucose 4-epimerase (GalE-1)/0.449
3p62FMNPentaerythritol tetranitrate reductase/0.449
4dquNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.449
4g3jVNTLanosterol 14-alpha-demethylase/0.449
4rnuFMNNADPH dehydrogenase 11.6.99.10.449
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.448
4gk2L66Ephrin type-A receptor 32.7.10.10.448
1nvtNAPShikimate dehydrogenase (NADP(+))/0.447
2ohvNHLGlutamate racemase/0.447
3p74FMNPentaerythritol tetranitrate reductase/0.447
5a9sNAPPutative dehydrogenase/0.447
1adfTADAlcohol dehydrogenase E chain1.1.1.10.446
1jioDEB6-deoxyerythronolide B hydroxylase/0.446
2dfvNADL-threonine 3-dehydrogenase/0.446
3atzFMNProstaglandin F2a synthase/0.446
3oev3OEProteasome subunit beta type-53.4.25.10.446
3oev3OEProteasome subunit beta type-63.4.25.10.446
3p67FMNPentaerythritol tetranitrate reductase/0.446
3s1dZIRCytokinin dehydrogenase 11.5.99.120.446
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.445
3hgsFMN12-oxophytodienoate reductase 31.3.1.420.445
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.444
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.444
1udaUFGUDP-glucose 4-epimerase5.1.3.20.444
1h63FMNPentaerythritol tetranitrate reductase/0.443
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.443
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.443
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.443
4ure1PSCyclohexanol dehydrogenase/0.443
1h74AGSHomoserine kinase2.7.1.390.442
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.442
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.442
1icpFMN12-oxophytodienoate reductase 11.3.1.420.441
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4h8aNAIUreidoglycolate dehydrogenase (NAD(+))1.1.1.3500.441
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440
2j3jHC4NADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.440
2q9fC3SCholesterol 24-hydroxylase/0.440
3r9uFADThioredoxin reductase/0.440
4tuvCPZCytochrome P450 1191.140.440