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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1ankANPAdenylate kinase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1ankANPAdenylate kinase/1.000
4qbiAP5Adenylate kinase/0.627
1akeAP5Adenylate kinase/0.590
3hpqAP5Adenylate kinase/0.589
4x8oAP5Adenylate kinase/0.587
1p3jAP5Adenylate kinase/0.571
4jl5ADPAdenylate kinase/0.566
2osbAP5Adenylate kinase/0.564
1e4yAP5Adenylate kinase/0.560
2eu8AP5Adenylate kinase/0.560
3dl0AP5Adenylate kinase/0.559
2oo7AP5Adenylate kinase/0.558
3dkvAP5Adenylate kinase/0.554
4cf7ADPAdenylate kinase/0.553
4jloADPAdenylate kinase/0.551
4w5jAP5Adenylate kinase/0.546
2qajAP5Adenylate kinase/0.544
4jl6ADPAdenylate kinase/0.541
3tlxADPAdenylate kinase 2/0.539
4ikeADPAdenylate kinase/0.538
4qbhAP5Adenylate kinase/0.536
2eckADPAdenylate kinase/0.523
4nu0AP5Adenylate kinase/0.516
1zioAP5Adenylate kinase/0.510
4mkfAP5Adenylate kinase/0.510
4jldADPAdenylate kinase/0.506
1dvrATFAdenylate kinase/0.505
4x8lAP5Adenylate kinase/0.502
4mkgAP5Adenylate kinase/0.500
2akyAP5Adenylate kinase/0.490
2ql6ADPNicotinamide riboside kinase 1/0.479
2rgxAP5Adenylate kinase/0.476
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.470
2olrATPPhosphoenolpyruvate carboxykinase (ATP)/0.469
2py7ATPPhosphoenolpyruvate carboxykinase (ATP)/0.468
2rl1UD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.465
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.465
3swqEPUUDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.464
4loh1SYStimulator of interferon genes protein/0.464
3vcyUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.462
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.462
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.461
3u4cNDPNADPH-dependent reductase BacG/0.459
1e5qNDPSaccharopine dehydrogenase [NADP(+), L-glutamate-forming]1.5.1.100.458
2yvwEPUUDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.457
3lqfNADGalactitol dehydrogenase/0.457
3r9iADPSeptum site-determining protein MinD/0.457
3w6uNAP6-phosphogluconate dehydrogenase, NAD-binding protein/0.457
3zeiAWHO-acetylserine sulfhydrylase/0.457
3mx5UTPNucleoprotein/0.456
4yp12BAStimulator of interferon genes protein/0.456
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.456
4nfsNAJAlcohol dehydrogenase E chain1.1.1.10.455
4jkyADPAdenylate kinase/0.454
3tn7NJPShort-chain alcohol dehydrogenase/0.453
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.452
4loi1YCStimulator of interferon genes protein/0.452
3mw9NAIGlutamate dehydrogenase 1, mitochondrial1.4.1.30.451
1ytmATPPhosphoenolpyruvate carboxykinase (ATP)/0.449
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.449
1ju9NADAlcohol dehydrogenase E chain1.1.1.10.448
1nhrFADNADH peroxidase1.11.1.10.448
1snyNAPLD36273p/0.448
1svmATPLarge T antigen3.6.40.448
3v4tUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.448
5js6NAD17-beta-hydroxysteroid dehydrogenase 141.1.10.448
1p9wANPType II secretion system protein E/0.447
4c13UMLUDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase/0.447
4kq2U5PGlycogen [starch] synthase isoform 22.4.1.110.447
1q3gUDAUDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.446
2q4bNAPUncharacterized protein At5g02240/0.446
2vprTDCTetracycline repressor protein class H/0.446
3upkUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.446
3kjiADPCO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC/0.445
4g9kFADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.445
4gyzD5MTyrosyl-DNA phosphodiesterase 23.1.40.445
1dxyNADD-2-hydroxyisocaproate dehydrogenase1.1.10.444
1ipeNDPTropinone reductase 21.1.1.2360.444
5adhAPRAlcohol dehydrogenase E chain1.1.1.10.444
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4wriOKAOkadaic acid binding protein 2-alpha/0.443
1os1ATPPhosphoenolpyruvate carboxykinase (ATP)/0.442
1tqf32PBeta-secretase 13.4.23.460.442
2wsbNADGalactitol dehydrogenase/0.442
5idwNAPShort-chain dehydrogenase/reductase SDR/0.442
5kjcNAJAlcohol dehydrogenase E chain1.1.1.10.442
1qjfACSIsopenicillin N synthase1.21.3.10.441
2yvfNADFerredoxin reductase/0.441
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.441
3kroIPEGeranyl diphosphate synthase large subunit/0.441
3t58FADSulfhydryl oxidase 11.8.3.20.441
5kgpACOPredicted acetyltransferase/0.441
1i2lDCSAminodeoxychorismate lyase4.1.3.380.440
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.440
1ybmNAPUncharacterized protein At5g02240/0.440
2oapANPType II secretion system protein (GspE-2)/0.440
3enkUPGUDP-glucose 4-epimerase/0.440
4bizADPSensor histidine kinase CpxA/0.440
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.440