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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1adsNAPAldose reductase1.1.1.21

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1adsNAPAldose reductase1.1.1.211.000
1z8aNAPAldose reductase1.1.1.210.755
2pf8NDPAldose reductase1.1.1.210.680
2j8tNAPAldose reductase1.1.1.210.675
2acqNAPAldose reductase1.1.1.210.656
3v36NAPAldose reductase1.1.1.210.645
2pfhNDPAldose reductase1.1.1.210.638
2acuNAPAldose reductase1.1.1.210.636
1az2NAPAldose reductase1.1.1.210.633
3q65NAPAldose reductase1.1.1.210.632
1ah4NAPAldose reductase1.1.1.210.631
2iq0NAPAldose reductase1.1.1.210.631
1x98NAPAldose reductase1.1.1.210.628
2pevNDPAldose reductase1.1.1.210.621
3q67NAPAldose reductase1.1.1.210.615
3h7rNAPAldo-keto reductase family 4 member C8/0.614
2acsNAPAldose reductase1.1.1.210.602
1x96NAPAldose reductase1.1.1.210.594
4pmjNAPPutative oxidoreductase/0.591
3qkzNAPAldose reductase-related protein 11.1.1.210.584
1c9wNAPAldose reductase-related protein 2/0.579
1q5mNDPProstaglandin-E(2) 9-reductase1.1.1.1890.579
4g5dNDPProstaglandin F synthase1.1.1.1880.578
3h7uNAPNADPH-dependent aldo-keto reductase, chloroplastic/0.576
2hejNDPAldo-keto reductase family 1 member C211.1.10.573
3o3rNAPAldose reductase-related protein 11.1.1.210.564
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.548
5c7hNDPPutative oxidoreductase/0.543
2hdjNDPAldo-keto reductase family 1 member C2/0.542
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.540
1k8cNAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.538
3wbwNDPPutative 2,5-diketo-D-gluconic acid reductase/0.536
2fvlNAPAldo-keto reductase family 1 member C41.1.1.2250.534
1lqaNDPProtein tas/0.532
4xo7NAPAldo-keto reductase family 1 member C2/0.532
4dz5NAPAldo-keto reductase family 1 member C3/0.529
1zgdNAPChalcone reductase/0.526
1s1rNAPAldo-keto reductase family 1 member C3/0.521
4jtqNAPAldo-keto reductase family 1 member C2/0.521
4l1xNAPAldo-keto reductase family 1 member C2/0.518
1a80NDP2,5-diketo-D-gluconic acid reductase A1.1.1.3460.517
1mi3NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.513
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.508
4aubNAPL-glyceraldehyde 3-phosphate reductase1.1.10.508
3caqNDP3-oxo-5-beta-steroid 4-dehydrogenase/0.506
3wczNAPAldo-keto reductase AKR2E4/0.506
4ijrNDPD-arabinose dehydrogenase [NAD(P)+] heavy chain1.1.1.1170.505
2p5nNDPAldo-keto reductase family 1 member C211.1.10.504
1vp5NAPOxidoreductase, aldo/keto reductase family/0.500
4jtcNAPVoltage-gated potassium channel subunit beta-2/0.499
1r38NAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.496
4jtdNAPVoltage-gated potassium channel subunit beta-2/0.496
3buvNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.495
3lnmNAPVoltage-gated potassium channel subunit beta-2/0.495
1ye6NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.493
4jq3NAPAldo-keto reductase family 1 member C2/0.493
4xzmNAPAldo-keto reductase family 1 member B101.1.10.493
1ye4NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.491
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.490
1sm9NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.483
2r9rNAPVoltage-gated potassium channel subunit beta-2/0.481
1z9aNADNAD(P)H-dependent D-xylose reductase1.1.1.3070.480
2clpNDPAflatoxin B1 aldehyde reductase member 3/0.480
3wg6NDPNADPH-dependent conjugated polyketone reductase C1/0.480
1ef3NAPAldose reductase1.1.1.210.477
2vdgNDPAldose reductase1.1.1.210.477
4jtaNAPVoltage-gated potassium channel subunit beta-2/0.477
1pz1NAPGeneral stress protein 69/0.475
1og6NAPOxidoreductase YdhF10.461
1lwiNAP3-alpha-hydroxysteroid dehydrogenase1.1.1.500.457
1s1pNAPAldo-keto reductase family 1 member C3/0.456
4xznNAPAldo-keto reductase family 1 member B101.1.10.451
2he5NDPAldo-keto reductase family 1 member C211.1.10.449
1ye6NAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.446