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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5l8j ADP Aurora kinase A 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5l8j ADPAurora kinase A 2.7.11.1 0.881
5l8l ADPAurora kinase A 2.7.11.1 0.829
5l8k ADPAurora kinase A 2.7.11.1 0.828
4c3r ACPAurora kinase A 2.7.11.1 0.741
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.737
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.735
3c4w ATPRhodopsin kinase / 0.724
2pzp ACPFibroblast growth factor receptor 2 / 0.718
1mq4 ADPAurora kinase A 2.7.11.1 0.710
2pup ADPMethylthioribose kinase 2.7.1.100 0.704
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.704
4ceg ADPAurora kinase A 2.7.11.1 0.703
2pz5 ACPFibroblast growth factor receptor 2 / 0.702
2wqe ADPAurora kinase A 2.7.11.1 0.698
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.697
4utd ACPAurora kinase A 2.7.11.1 0.696
2py3 ACPFibroblast growth factor receptor 2 / 0.692
2pul ACPMethylthioribose kinase 2.7.1.100 0.687
4pl3 ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.686
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.684
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.684
4n57 ADPAPH(2'')-Id / 0.684
4o4d ATPKinase / 0.683
1w2c ANPInositol-trisphosphate 3-kinase A 2.7.1.127 0.681
3ori AGSSerine/threonine protein kinase / 0.680
4fg7 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.680
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.679
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.678
1w2d ADPInositol-trisphosphate 3-kinase A 2.7.1.127 0.676
3tpt ADPSerine/threonine-protein kinase toxin HipA / 0.674
3b2t M33Fibroblast growth factor receptor 2 / 0.673
3nie ANPMitogen-activated protein kinase / 0.673
4fg8 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.673
3c4z ADPRhodopsin kinase / 0.672
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.672
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.671
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.671
4o1p ANPRibonuclease L / 0.671
2dwb ANPAurora kinase A 2.7.11.1 0.670
2qoq ANPEphrin type-A receptor 3 2.7.10.1 0.670
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.669
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.668
3c50 ADPRhodopsin kinase / 0.668
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.668
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.667
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.667
3c4x ATPRhodopsin kinase / 0.666
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.666
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.666
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.665
5dt4 ATPAurora kinase A 2.7.11.1 0.665
2pun ACPMethylthioribose kinase 2.7.1.100 0.664
3cly ACPFibroblast growth factor receptor 2 / 0.664
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.664
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.664
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.663
3ung ADPCRISPR system Cmr subunit Cmr2 / 0.663
2r5t ANPSerine/threonine-protein kinase Sgk1 2.7.11.1 0.662
4j98 ACPFibroblast growth factor receptor 2 / 0.662
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.661
3orm AGSSerine/threonine protein kinase / 0.661
1ol6 ATPAurora kinase A 2.7.11.1 0.660
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.660
3bu5 ATPInsulin receptor 2.7.10.1 0.660
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.660
1u54 ACPActivated CDC42 kinase 1 / 0.659
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.659
3fzp AGSProtein-tyrosine kinase 2-beta 2.7.10.2 0.658
3mfs ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.658
4b8l A0PAurora kinase B-A 2.7.11.1 0.658
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.658
4ysj ADPCalmodulin-like domain protein kinase / 0.658
2ijm ATPFocal adhesion kinase 1 2.7.10.2 0.657
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.657
2pvr ANPCasein kinase II subunit alpha 2.7.11.1 0.656
4s33 ANPMitogen-activated protein kinase 1 2.7.11.24 0.656
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.655
4dee ADPAurora kinase A 2.7.11.1 0.655
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.655
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.655
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.655
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.654
3r5f ATPD-alanine--D-alanine ligase / 0.654
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.654
2pui ADPMethylthioribose kinase 2.7.1.100 0.653
2pyw ADPMethylthioribose kinase 2.7.1.100 0.653
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.653
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.652
3gub GUBDeath-associated protein kinase 1 2.7.11.1 0.652
1z2n ADPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.651
3pdt ADPMyosin heavy chain kinase A 2.7.11.7 0.651
2eva ADNMitogen-activated protein kinase kinase kinase 7 2.7.11.25 0.650
3mia ANPCyclin-dependent kinase 9 2.7.11.22 0.650
4y0x ADPSerine/threonine-protein kinase PknG 2.7.11.1 0.650