Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5iqh GNP Bifunctional AAC/APH 2.3.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5iqh GNPBifunctional AAC/APH 2.3.1 1.015
5byl GCPBifunctional AAC/APH 2.3.1 0.962
5iqb GNPBifunctional AAC/APH 2.3.1 0.900
5iqi GNPBifunctional AAC/APH 2.3.1 0.898
5iqa GNPBifunctional AAC/APH 2.3.1 0.888
5iqe GNPBifunctional AAC/APH 2.3.1 0.879
5iqd GNPBifunctional AAC/APH 2.3.1 0.878
5iqf GDPBifunctional AAC/APH 2.3.1 0.843
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.795
4ork GDPBifunctional AAC/APH 2.3.1 0.795
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.794
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.787
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.767
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.767
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.762
3tdw GDPGentamicin resistance protein / 0.754
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.748
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.746
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.746
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.743
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.739
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.739
4o4d ATPKinase / 0.737
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.727
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.726
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.726
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.725
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.725
4gyi ADPUncharacterized protein / 0.724
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.723
4ceg ADPAurora kinase A 2.7.11.1 0.722
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.721
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.720
5iqg GDPBifunctional AAC/APH 2.3.1 0.718
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.717
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.717
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.716
2hgs ADPGlutathione synthetase 6.3.2.3 0.712
3t8o ATPRhodopsin kinase / 0.710
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.709
2py3 ACPFibroblast growth factor receptor 2 / 0.708
3cly ACPFibroblast growth factor receptor 2 / 0.708
4n57 ADPAPH(2'')-Id / 0.708
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.707
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.707
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.707
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.707
4utd ACPAurora kinase A 2.7.11.1 0.707
2pul ACPMethylthioribose kinase 2.7.1.100 0.706
3c50 ADPRhodopsin kinase / 0.706
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.706
3c4z ADPRhodopsin kinase / 0.705
3bu5 ATPInsulin receptor 2.7.10.1 0.704
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.704
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.703
3t9a ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.703
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.699
2olc ADPMethylthioribose kinase 2.7.1.100 0.698
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.698
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.698
3tpt ADPSerine/threonine-protein kinase toxin HipA / 0.697
1day GNPCasein kinase II subunit alpha 2.7.11.1 0.696
3tdv GDPGentamicin resistance protein / 0.696
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.696
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.696
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.696
3dnt ATPSerine/threonine-protein kinase toxin HipA / 0.695
3t9d ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.694
3wo0 ADPAlanine--anticapsin ligase / 0.694
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.694
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.693
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.692
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.692
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.690
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.688
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.688
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.687
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.686
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.686
4c3r ACPAurora kinase A 2.7.11.1 0.684
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.684
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.683
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.682
2pzp ACPFibroblast growth factor receptor 2 / 0.682
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.682
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.681
4c5c ATPD-alanine--D-alanine ligase B 6.3.2.4 0.681
2io8 ADPBifunctional glutathionylspermidine synthetase/amidase / 0.680
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.680
4ysj ADPCalmodulin-like domain protein kinase / 0.680
1z2p ACPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.679
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.678
2pz5 ACPFibroblast growth factor receptor 2 / 0.678
5dos ATPAurora kinase A 2.7.11.1 0.678
1m0w ANPGlutathione synthetase 6.3.2.3 0.677
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.676
3wnz ADPAlanine--anticapsin ligase / 0.675
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.675
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.674
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.673
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.671
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.670
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.669
3dyn PCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A / 0.669
1mq4 ADPAurora kinase A 2.7.11.1 0.668
4dee ADPAurora kinase A 2.7.11.1 0.668
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.667
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.667
5dn3 ATPAurora kinase A 2.7.11.1 0.667
3vpb ADPGlutamate--LysW ligase ArgX 6.3.2 0.665
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.665
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.665
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.664
4jr7 GNPCasein kinase II subunit alpha 2.7.11.1 0.664
2pup ADPMethylthioribose kinase 2.7.1.100 0.663
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.663
1bmf ADPATP synthase subunit alpha, mitochondrial / 0.662
1bmf ADPATP synthase subunit beta, mitochondrial 3.6.3.14 0.662
1w2c ANPInositol-trisphosphate 3-kinase A 2.7.1.127 0.661
3qc9 ADPRhodopsin kinase / 0.661
3eth ATPN5-carboxyaminoimidazole ribonucleotide synthase / 0.660
5dt3 ATPAurora kinase A 2.7.11.1 0.660
1ol6 ATPAurora kinase A 2.7.11.1 0.659
5dnr ATPAurora kinase A 2.7.11.1 0.659
1cm8 ANPMitogen-activated protein kinase 12 / 0.658
1ss9 UPFLgtC / 0.657
3px3 T3QdTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase 2.1.1.235 0.657
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.657
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.657
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.656
4ehu ANP2-hydroxyisocaproyl-CoA dehydratase activator / 0.655
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.654
2pui ADPMethylthioribose kinase 2.7.1.100 0.653
2pyw ADPMethylthioribose kinase 2.7.1.100 0.653
3t9f ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.653
4aqk ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.653
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.652
5c1o ANPD-alanine--D-alanine ligase / 0.652
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.651
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.651
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.651
1w2d ADPInositol-trisphosphate 3-kinase A 2.7.1.127 0.650
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.650
3c4w ATPRhodopsin kinase / 0.650