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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5cvh ADP Casein kinase II subunit alpha 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.953
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.809
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.777
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.776
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.773
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.772
4dee ADPAurora kinase A 2.7.11.1 0.762
2pui ADPMethylthioribose kinase 2.7.1.100 0.761
4gyi ADPUncharacterized protein / 0.757
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.755
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.755
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.753
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.751
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.746
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.737
5dt3 ATPAurora kinase A 2.7.11.1 0.736
3c4z ADPRhodopsin kinase / 0.735
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.735
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.734
5dr2 ATPAurora kinase A 2.7.11.1 0.734
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.732
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.730
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.729
3qc9 ADPRhodopsin kinase / 0.727
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.726
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.726
3g8d ADPBiotin carboxylase 6.3.4.14 0.724
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.721
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.720
3t9f ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.720
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.720
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.720
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.717
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.717
2olc ADPMethylthioribose kinase 2.7.1.100 0.714
3ori AGSSerine/threonine protein kinase / 0.711
2pul ACPMethylthioribose kinase 2.7.1.100 0.710
2pun ACPMethylthioribose kinase 2.7.1.100 0.709
4ceg ADPAurora kinase A 2.7.11.1 0.709
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.709
4utd ACPAurora kinase A 2.7.11.1 0.709
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.707
3wow ANPCasein kinase II subunit alpha 2.7.11.1 0.706
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.705
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.704
5dn3 ATPAurora kinase A 2.7.11.1 0.704
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.703
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.703
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.703
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.702
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.702
4jr7 GNPCasein kinase II subunit alpha 2.7.11.1 0.701
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.701
4ysj ADPCalmodulin-like domain protein kinase / 0.701
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.700
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.699
3t99 ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.699
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.699
1mq4 ADPAurora kinase A 2.7.11.1 0.698
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.698
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.697
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.697
2eb3 ANPEpidermal growth factor receptor 2.7.10.1 0.695
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.695
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.693
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.693
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.693
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.692
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.692
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.692
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.691
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.691
4xlv ACPInsulin receptor 2.7.10.1 0.689
4q4c ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.688
1tqp ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.687
3c50 ADPRhodopsin kinase / 0.687
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.686
1m0w ANPGlutathione synthetase 6.3.2.3 0.685
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.685
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.685
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.685
5dos ATPAurora kinase A 2.7.11.1 0.685
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.684
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.684
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.683
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.683
3t8o ATPRhodopsin kinase / 0.683
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.680
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.680
3bu5 ATPInsulin receptor 2.7.10.1 0.680
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.680
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.679
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.678
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.678
3rv4 ADPBiotin carboxylase 6.3.4.14 0.678
5dt4 ATPAurora kinase A 2.7.11.1 0.678
3i12 ADPD-alanine--D-alanine ligase A 6.3.2.4 0.677
3ort AGSSerine/threonine protein kinase / 0.677
4nzo ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.677
5drd ATPAurora kinase A 2.7.11.1 0.677
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.676
2qoq ANPEphrin type-A receptor 3 2.7.10.1 0.676
1pjk ANPCasein kinase II subunit alpha 2.7.11.1 0.675
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.675
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.675
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.674
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.674
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.674
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.674
5dmz ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.674
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.673
3wnz ADPAlanine--anticapsin ligase / 0.673
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.673
5dnr ATPAurora kinase A 2.7.11.1 0.673
2ijm ATPFocal adhesion kinase 1 2.7.10.2 0.672
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.672
3t9d ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.671
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.670
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.670
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.669
2vuw 5IDSerine/threonine-protein kinase haspin 2.7.11.1 0.669
2pyw ADPMethylthioribose kinase 2.7.1.100 0.668
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.667
4f1m ACPProbable serine/threonine-protein kinase roco4 2.7.11.1 0.667
5byl GCPBifunctional AAC/APH 2.3.1 0.667
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.666
1u54 ACPActivated CDC42 kinase 1 / 0.664
4q5h ANPProtein kinase OspG 2.7 0.664
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.663
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.662
3cly ACPFibroblast growth factor receptor 2 / 0.662
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.662
3mfs ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.662
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.662
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.662
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.662
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.661
4ffl ADPUncharacterized protein / 0.661
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.661
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.660
4ork GDPBifunctional AAC/APH 2.3.1 0.660
3g8c ADPBiotin carboxylase 6.3.4.14 0.659
1day GNPCasein kinase II subunit alpha 2.7.11.1 0.658
1q99 ANPSerine/threonine-protein kinase SKY1 2.7.11.1 0.658
4wh2 ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.658
3att ATPPutative aminoglycoside phosphotransferase 2.7.1 0.657
4ffm ADPUncharacterized protein / 0.657
4fg8 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.657
2pup ADPMethylthioribose kinase 2.7.1.100 0.656
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.656
4ocp ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.656
4qny ANPMitogen activated protein kinase, putative / 0.656
1mab ADPATP synthase subunit beta, mitochondrial 3.6.3.14 0.655
3llt ANPProtein serine/threonine kinase-1 / 0.655
4riy ADPEpidermal growth factor receptor 2.7.10.1 0.655
2j0l ANPFocal adhesion kinase 1 2.7.10.2 0.654
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.654
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.654
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.654
4o4d ATPKinase / 0.654
1ol6 ATPAurora kinase A 2.7.11.1 0.653
4pds ANPSerine/threonine-protein kinase RAD53 2.7.12.1 0.653
4xj4 3ATCyclic GMP-AMP synthase / 0.653
4yxs EMUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.653
3mia ANPCyclin-dependent kinase 9 2.7.11.22 0.652
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.651
1ny3 ADPMAP kinase-activated protein kinase 2 2.7.11.1 0.651
3nyn SGVG protein-coupled receptor kinase 6 2.7.11.16 0.651
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.651
2dwb ANPAurora kinase A 2.7.11.1 0.650
2io9 ADPBifunctional glutathionylspermidine synthetase/amidase / 0.650
2itv ANPEpidermal growth factor receptor 2.7.10.1 0.650