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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ttc FMN Iodotyrosine deiodinase 1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4ttc FMNIodotyrosine deiodinase 1 / 1.465
3gfd FMNIodotyrosine deiodinase 1 1.21.1.1 1.300
3gh8 FMNIodotyrosine deiodinase 1 1.21.1.1 1.148
3to0 FMNIodotyrosine deiodinase 1 1.21.1.1 1.053
4ttb FMNIodotyrosine deiodinase 1 / 1.030
3hj9 FMNUncharacterized protein / 0.946
2isl FNR5,6-dimethylbenzimidazole synthase 1.13.11.79 0.870
3eo8 FMNPutative nitroreductase / 0.866
3e39 FMNNitroreductase / 0.858
4qly FMNEnone reductase CLA-ER / 0.850
4xoo FMNCoenzyme F420:L-glutamate ligase / 0.841
3x22 FMNOxygen-insensitive NAD(P)H nitroreductase / 0.838
3gag FMNPutative NADH dehydrogenase NAD(P)H nitroreductase / 0.829
4eo3 FMNBacterioferritin comigratory protein/NADH dehydrogenase / 0.829
2wzw FMNNitroreductase NfnB / 0.819
2bkj FMNNADPH-flavin oxidoreductase / 0.801
1oo5 FMNOxygen-insensitive NAD(P)H nitroreductase / 0.790
3koq FMNPutative nitroreductase / 0.786
2wzv FMNNitroreductase NfnB / 0.772
2ifa FMNUncharacterized protein / 0.768
3qdl FMNOxygen-insensitive NADPH nitroreductase / 0.768
3x21 FMNOxygen-insensitive NAD(P)H nitroreductase / 0.768
3bem FMNPutative NAD(P)H nitroreductase MhqN 1 0.763
3eof FMNPutative oxidase / 0.758
2isk FNR5,6-dimethylbenzimidazole synthase 1.13.11.79 0.751
2eba FADPutative glutaryl-CoA dehydrogenase / 0.748
2isj FMN5,6-dimethylbenzimidazole synthase 1.13.11.79 0.748
1ylr FMNOxygen-insensitive NAD(P)H nitroreductase / 0.743
2hay FMNPutative NAD(P)H-flavin oxidoreductase / 0.741
2z1q FADAcyl-CoA dehydrogenase / 0.740
3of4 FMNNitroreductase / 0.732
4p13 FADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial 1.3.8.7 0.729
3pxv FMNNitroreductase / 0.728
1vfr FMNMajor NAD(P)H-flavin oxidoreductase 1.6.99 0.724
3oib FDAPutative acyl-CoA dehydrogenase / 0.724
3ge6 FMNNitroreductase / 0.723
4iv6 FDAIsovaleryl-CoA dehydrogenase / 0.723
4tmc FMNOld yellow enzyme / 0.719
3mdd FADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial 1.3.8.7 0.718
5jsc FADPutative acyl-CoA dehydrogenase / 0.715
3r7k FDAProbable acyl CoA dehydrogenase / 0.712
1x0p FADTll0078 protein / 0.710
1icu FMNOxygen-insensitive NAD(P)H nitroreductase / 0.707
3hgo FMN12-oxophytodienoate reductase 3 1.3.1.42 0.707
1ylu FMNOxygen-insensitive NAD(P)H nitroreductase / 0.704
2i51 FMNPyridoxamine 5'-phosphate oxidase-related, FMN-binding / 0.704
3p4t FAOPutative acyl-CoA dehydrogenase / 0.704
4y9l FADAcyl-CoA dehydrogenase family member 11 / 0.704
1yki FMNOxygen-insensitive NAD(P)H nitroreductase / 0.701
3djl FADPutative acyl-CoA dehydrogenase AidB 1.3.99 0.701
2zry FNRIsopentenyl-diphosphate delta-isomerase / 0.698
3c3n FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.698
2d29 FADAcyl-CoA dehydrogenase / 0.697
4hj3 FMNLOV protein / 0.696
5fs7 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.695
4hj6 FMNLOV protein / 0.694
1kqc FMNOxygen-insensitive NAD(P)H nitroreductase / 0.692
4wqm FADToluene-4-monooxygenase electron transfer component 1.18.1.3 0.692
4jic FMNGTN Reductase / 0.691
4b5n FMNNAD(P)H:flavin oxidoreductase Sye4 / 0.689
1a8p FADFerredoxin--NADP reductase / 0.688
1buc FADAcyl-CoA dehydrogenase, short-chain specific 1.3.8.1 0.688
3sf6 FDAGlutaryl-CoA dehydrogenase / 0.687
4h6k FMNNADPH dehydrogenase 1 1.6.99.1 0.686
4utl FNRXenobiotic reductase / 0.686
3a3b RBFLumazine protein / 0.685
4m0c FMNFMN-dependent NADH-azoreductase 1 / 0.685
3gsi FADDimethylglycine oxidase 1.5.3.10 0.684
2zfa FMNLactate oxidase / 0.683
1kqb FMNOxygen-insensitive NAD(P)H nitroreductase / 0.682
2b3d FADModulator of drug activity B / 0.682
2c3d FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.682
4rnx FMNNADPH dehydrogenase 1 1.6.99.1 0.682
4zvn FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.682
5fs6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.681
2qmy FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.680
2fre FMNNAD(P)H-flavin oxidoreductase / 0.679
4zvl FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.679
1h81 FADPolyamine oxidase 1.5.3.14 0.678
2h8x FMNXenA / 0.678
1gwj FMNMorphinone reductase / 0.677
1nec FMNOxygen-insensitive NAD(P)H nitroreductase 1 0.677
1oon FMNOxygen-insensitive NAD(P)H nitroreductase / 0.677
2gr3 FADFerredoxin reductase / 0.677
4hia FMNLOV protein / 0.677
1kqd FMNOxygen-insensitive NAD(P)H nitroreductase / 0.676
1usc FMNMonooxygenase / 0.675
2v0u FMNNPH1-1 / 0.675
4cw5 FMNDfnA / 0.675
5j60 FADThioredoxin reductase / 0.673
1jue FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.671
1oya FMNNADPH dehydrogenase 1 1.6.99.1 0.671
4h4s FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.671
4h4y FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.670
4utk FNRXenobiotic reductase / 0.670
5fs9 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.670
2byc FMNBlue-light receptor of the BLUF-family / 0.667
1bwk FMNNADPH dehydrogenase 1 1.6.99.1 0.666
1d7y FADFerredoxin reductase / 0.666
1icv FMNOxygen-insensitive NAD(P)H nitroreductase / 0.666
3rh7 FMNUncharacterized protein / 0.666
2pdt FADVivid PAS protein VVD / 0.665
3hji FADVivid PAS protein VVD / 0.665
1eje FMNProtein MTH_152 / 0.664
3a20 FMNFMN-binding protein / 0.664
2yr5 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.663
1oyc FMNNADPH dehydrogenase 1 1.6.99.1 0.662
1p0n FMNIsopentenyl-diphosphate delta-isomerase / 0.662
1ps9 FAD2,4-dienoyl-CoA reductase 1.3.1.34 0.662
3jqr FADFerredoxin--NADP reductase, apicoplast / 0.661
3pfd FDAAcyl-CoA dehydrogenase FadE25 / 0.661
4ech FADPolyamine oxidase FMS1 / 0.661
1dor FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.660
1yrx FMNAppA protein / 0.660
2gqa FMNNADH:flavin oxidoreductase Sye1 / 0.660
1gg5 FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.659
1rx0 FADIsobutyryl-CoA dehydrogenase, mitochondrial 1.3.99 0.659
2qcu FADAerobic glycerol-3-phosphate dehydrogenase 1.1.5.3 0.659
3ad9 FADSubunit beta of sarcosine oxidase / 0.659
4bmo FMNProtein NrdI / 0.659
1udy FADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial 1.3.8.7 0.658
2pg0 FADAcyl-CoA dehydrogenase / 0.658
3aty FMNProstaglandin F2a synthase / 0.658
4qoe FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.658
4wct FADFructosyl amine:oxygen oxidoreductase / 0.658
1czn FMNFlavodoxin / 0.657
2ix5 FADAcyl-coenzyme A oxidase 4, peroxisomal 1.3.3.6 0.657
3n39 FMNProtein NrdI / 0.657
4k7y FMNNADPH dehydrogenase 1 1.6.99.1 0.657
1i0s FMNFerric-chelate reductase (NAD(P)H) / 0.656
1mok FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.655
3f90 FMNFlavodoxin / 0.655
5dbj FADFADH2-dependent halogenase PltA / 0.655
1h66 FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.654
1vji FMN12-oxophytodienoate reductase 1 1.3.1.42 0.654
2ylt FADPhenylacetone monooxygenase 1.14.13.92 0.654
3hgs FMN12-oxophytodienoate reductase 3 1.3.1.42 0.654
1ng3 FADGlycine oxidase 1.4.3.19 0.653
1zmc FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.653
4h4u FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.653
4x28 FDAAcyl-CoA dehydrogenase FadE26 / 0.653
4x28 FDAAcyl-CoA dehydrogenase FadE27 / 0.653
1jub FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.652
2e77 FMNLactate oxidase / 0.652
3zc3 FADFerredoxin--NADP reductase 1.18.1.2 0.652
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.651
2zrx FMNIsopentenyl-diphosphate delta-isomerase / 0.651
5cho FADFlavin reductase / 0.651
1v0j FADUDP-galactopyranose mutase 5.4.99.9 0.650
2jbs FMNp-hydroxyphenylacetate 3-hydroxylase, oxygenase component / 0.650