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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4oxy NAD Enoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4oxy NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 1.202
4trn NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 1.008
4m87 NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.996
3oey NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.958
3of2 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.958
3oew NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.953
4dti NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.950
2nv6 ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.946
2b35 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.945
5koi NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.940
1eny NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.936
2wyv NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.930
4zju NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.929
4dre NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.918
2aqh NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.912
4bgi NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.902
4bqp NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.892
2b37 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.891
4dqu NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.884
2aqk NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.858
2aqi NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.856
5cpb NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.856
4bii NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.852
2aq8 NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.847
2idz ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.822
3uic NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.819
1vrw NAIEnoyl-ACP reductase / 0.818
3r3s NADPutative oxidoreductase / 0.807
4qxm NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.805
2h9i EADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.802
2ntv P1HEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.795
2b36 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.790
1p44 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.783
4bmv NAPShort-chain dehydrogenase / 0.783
4z3d NDPCarbonyl reductase [NADPH] 1 1.1.1.184 0.775
2ieb ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.774
1enz NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.772
2yut NAPPutative short-chain oxidoreductase / 0.771
3ijr NADOxidoreductase, short chain dehydrogenase/reductase family / 0.771
2yw9 NAPEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.769
2ztm NADD(-)-3-hydroxybutyrate dehydrogenase / 0.766
5js6 NAD17-beta-hydroxysteroid dehydrogenase 14 1.1.1 0.764
2jah NDPClavaldehyde dehydrogenase / 0.761
2ie0 ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.759
2q2v NADBeta-D-hydroxybutyrate dehydrogenase / 0.759
2pr2 DG1Enoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.758
4hp8 NAP2-deoxy-D-gluconate 3-dehydrogenase / 0.758
1g0n NDPTetrahydroxynaphthalene reductase 1.1.1.252 0.753
1vl8 NAPOxidoreductase, short chain dehydrogenase/reductase family / 0.750
5jsf NAD17-beta-hydroxysteroid dehydrogenase 14 1.1.1 0.748
1h5q NAPNADP-dependent mannitol dehydrogenase 1.1.1.138 0.747
3rj9 NADAlcohol dehydrogenase 1.1.1.1 0.743
3w8f NAD3-hydroxybutyrate dehydrogenase / 0.743
5ig2 NADShort-chain dehydrogenase/reductase SDR / 0.743
5jyd NADShort chain dehydrogenase / 0.743
4o1m NADEnoyl-acyl carrier reductase / 0.739
3wds NADNADH-dependent quinuclidinone reductase / 0.738
3gy0 NAPNAD(P)-dependent oxidoreductase / 0.735
4qed NAPElxO / 0.735
2zat NAPDehydrogenase/reductase SDR family member 4 1.1.1.184 0.734
4nbt NAD3-oxoacyl-[acyl-carrier-protein] reductase / 0.733
2gdz NAD15-hydroxyprostaglandin dehydrogenase [NAD(+)] 1.1.1.141 0.731
2ntj P1HEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.731
4k6f NAPPutative Acetoacetyl-CoA reductase / 0.729
2ztl NADD(-)-3-hydroxybutyrate dehydrogenase / 0.728
4hxy NDPPlm1 / 0.726
1gee NADGlucose 1-dehydrogenase 1.1.1.47 0.723
3o03 NAPDehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase) / 0.723
3pgx NADUncharacterized NAD-dependent oxidoreductase MAP_4146 / 0.721
3w8d NAD3-hydroxybutyrate dehydrogenase / 0.721
3rj5 NADAlcohol dehydrogenase 1.1.1.1 0.720
4yai NAIC alpha-dehydrogenase / 0.720
1sny NAPLD36273p / 0.717
3iah NAPPutative oxoacyl-(Acyl carrier protein) reductase / 0.717
4b79 NADProbable short-chain dehydrogenase / 0.716
3ak4 NADNADH-dependent quinuclidinone reductase / 0.715
4qec NAPElxO / 0.715
2nq8 ZIDEnoyl-ACP reductase / 0.714
4bms NAPAlclohol dehydrogenase/short-chain dehydrogenase / 0.714
4is3 NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2 1.17.98.1 0.714
1bdb NADCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase / 0.713
2ztv NADD(-)-3-hydroxybutyrate dehydrogenase / 0.713
3ai3 NDPNADPH-sorbose reductase / 0.710
3vdq NAD3-hydroxybutyrate dehydrogenase / 0.710
2ztu NADD(-)-3-hydroxybutyrate dehydrogenase / 0.709
1rwb NADGlucose 1-dehydrogenase 1.1.1.47 0.708
1zem NADXylitol dehydrogenase / 0.708
4pvd NDPNADPH-dependent methylglyoxal reductase GRE2 / 0.707
1edo NAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic 1.1.1.100 0.706
3nug NADPyridoxal 4-dehydrogenase 1.1.1.107 0.704
3ai2 NDPNADPH-sorbose reductase / 0.701
2d1y NADOxidoreductase, short-chain dehydrogenase/reductase family / 0.700
1rkx NADCDP-D-glucose-4,6-dehydratase / 0.699
4iqg NAPShort-chain dehydrogenase/reductase SDR / 0.699
1ae1 NAPTropinone reductase 1 / 0.698
3bhi NAPCarbonyl reductase [NADPH] 1 1.1.1.184 0.694
4yag NAIC alpha-dehydrogenase / 0.693
1gco NADGlucose 1-dehydrogenase 1.1.1.47 0.692
1sby NADAlcohol dehydrogenase 1.1.1.1 0.691
3geg NADShort-chain dehydrogenase/reductase SDR / 0.691
1geg NADDiacetyl reductase [(S)-acetoin forming] 1.1.1.304 0.690
3w8e NAD3-hydroxybutyrate dehydrogenase / 0.687
4fc7 NAPPeroxisomal 2,4-dienoyl-CoA reductase 1.3.1.34 0.687
4fn4 NADShort chain dehydrogenase / 0.686
3tsc NADUncharacterized protein / 0.685
1cyd NDPCarbonyl reductase [NADPH] 2 1.1.1.184 0.683
4rf2 NAPNADPH dependent R-specific alcohol dehydrogenase / 0.683
1e6w NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.682
1x7g NAPPutative ketoacyl reductase 1.3.1 0.682
2rbe NDPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.682
3o26 NDPSalutaridine reductase / 0.682
4gh5 NADShort-chain dehydrogenase/reductase SDR / 0.680
3p19 NDPPutative blue fluorescent protein / 0.679
2c59 NADGDP-mannose 3,5-epimerase 5.1.3.18 0.678
2dkn NAI3-alpha-hydroxysteroid dehydrogenase / 0.678
4kwh NAPReductase homolog / 0.678
3zu2 NAIEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.677
1ipe NDPTropinone reductase 2 1.1.1.236 0.676
1xg5 NAPDehydrogenase/reductase SDR family member 11 / 0.676
3uxy NADShort-chain dehydrogenase/reductase SDR / 0.676
1e3w NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.675
2dte NAIGlucose 1-dehydrogenase related protein / 0.675
4wec NADShort chain dehydrogenase / 0.675
2wsb NADGalactitol dehydrogenase / 0.673
3mje NDPAmphB / 0.672
4ej0 NAPADP-L-glycero-D-manno-heptose-6-epimerase / 0.672
1v35 NAIEnoyl-ACP reductase / 0.670
3s55 NADPutative short-chain dehydrogenase/reductase / 0.670
5d2e NAPMlnE / 0.670
2yy7 NADL-threonine dehydrogenase / 0.669
3sx2 NADUncharacterized protein / 0.669
3h4v NAPPteridine reductase 1 1.5.1.33 0.668
3l77 NJPShort-chain alcohol dehydrogenase / 0.667
3qwf NAP17beta-hydroxysteroid dehydrogenase / 0.666
1pr9 NAPL-xylulose reductase 1.1.1.10 0.663
2ekp NAD2-deoxy-D-gluconate 3-dehydrogenase / 0.663
3sxp NADADP-L-glycero-D-mannoheptose-6-epimerase / 0.663
1fdu NAPEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.662
3a28 NADL-2,3-butanediol dehydrogenase 1.1.1.76 0.662
2ggs NDPdTDP-4-dehydrorhamnose reductase / 0.661
5bt9 NAP3-oxoacyl-(Acyl-carrier-protein) reductase / 0.661
3bmo NAPPteridine reductase / 0.660
3orf NADDihydropteridine reductase 1.5.1.34 0.660
3sju NDPKeto reductase / 0.659
4eue NAITrans-2-enoyl-CoA reductase [NADH] / 0.659
1i2b NADUDP-sulfoquinovose synthase, chloroplastic 3.13.1.1 0.658
1u7t TDT3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.657
1zid ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.657
2c54 NADGDP-mannose 3,5-epimerase 5.1.3.18 0.657
3qrw NDPPutative ketoacyl reductase 1.3.1 0.657
4clo NAPPteridine reductase / 0.657
4cql NADEstradiol 17-beta-dehydrogenase 8 1.1.1.62 0.657
1fk8 NAD3-alpha-hydroxysteroid dehydrogenase/carbonyl reductase 1.1.1.50 0.656
4i5e NAPAlclohol dehydrogenase/short-chain dehydrogenase / 0.656
1u7t NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.655
1n7g NDPGDP-mannose 4,6 dehydratase 2 4.2.1.47 0.654
4u7w NDPMxaA / 0.654
4n5n NAPAcetoacetyl-CoA reductase 1.1.1.36 0.653
3aut NAIGlucose 1-dehydrogenase 4 1.1.1.47 0.652
3f1k NAPUncharacterized oxidoreductase YciK 1 0.651
5jla NADPutative short-chain dehydrogenase/reductase / 0.650