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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4iqq D16 Thymidylate synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4iqq D16Thymidylate synthase / 0.851
1xxj UNCUricase 1.7.3.3 0.744
2d09 FLVBiflaviolin synthase CYP158A2 / 0.744
2jey HLOAcetylcholinesterase 3.1.1.7 0.744
3f8r NAPNADH oxidase/thioredoxin reductase / 0.744
3fzf ATPHeat shock cognate 71 kDa protein / 0.744
3wwm ADP[LysW]-aminoadipate kinase / 0.744
3ypi PGHTriosephosphate isomerase 5.3.1.1 0.744
3zzn ADPL-lactate dehydrogenase / 0.744
4a8m ATPRNA-directed RNA polymerase 2.7.7.48 0.744
4e5l DBHPolymerase acidic protein / 0.744
1h48 C5P2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 4.6.1.12 0.660
2puf GUNHTH-type transcriptional repressor PurR / 0.660
2xtn GTPGTPase IMAP family member 2 / 0.660
3vp6 HLDGlutamate decarboxylase 1 4.1.1.15 0.660
4uxj TTPThymidine kinase / 0.660
2tsr D16Thymidylate synthase 2.1.1.45 0.655
1n35 CH1RNA-directed RNA polymerase lambda-3 2.7.7.48 0.651