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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ic7 ANP Mitogen-activated protein kinase 7 2.7.11.24

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4ic7 ANPMitogen-activated protein kinase 7 2.7.11.24 0.931
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.758
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.754
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.753
1mq4 ADPAurora kinase A 2.7.11.1 0.750
4dee ADPAurora kinase A 2.7.11.1 0.739
5dt4 ATPAurora kinase A 2.7.11.1 0.737
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.736
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.735
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.734
4utd ACPAurora kinase A 2.7.11.1 0.730
3c4z ADPRhodopsin kinase / 0.728
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.727
5dos ATPAurora kinase A 2.7.11.1 0.727
5dn3 ATPAurora kinase A 2.7.11.1 0.726
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.724
2dwb ANPAurora kinase A 2.7.11.1 0.723
3c50 ADPRhodopsin kinase / 0.723
2olc ADPMethylthioribose kinase 2.7.1.100 0.721
2pui ADPMethylthioribose kinase 2.7.1.100 0.719
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.718
5dt3 ATPAurora kinase A 2.7.11.1 0.718
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.717
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.717
5dr2 ATPAurora kinase A 2.7.11.1 0.716
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.714
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.713
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.712
1ol6 ATPAurora kinase A 2.7.11.1 0.711
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.711
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.710
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.708
4ceg ADPAurora kinase A 2.7.11.1 0.707
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.706
4ysj ADPCalmodulin-like domain protein kinase / 0.705
3t8o ATPRhodopsin kinase / 0.704
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.703
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.703
3hrc ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.701
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.700
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.699
2yaa ATPDeath-associated protein kinase 2 / 0.699
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.699
3oro AGSSerine/threonine protein kinase / 0.697
3qc9 ADPRhodopsin kinase / 0.697
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.697
3llt ANPProtein serine/threonine kinase-1 / 0.696
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.695
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.695
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.695
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.694
3c4w ATPRhodopsin kinase / 0.694
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.693
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.693
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.693
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.692
2pun ACPMethylthioribose kinase 2.7.1.100 0.691
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.690
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.688
3ork AGSSerine/threonine protein kinase / 0.688
5drd ATPAurora kinase A 2.7.11.1 0.686
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.684
3cly ACPFibroblast growth factor receptor 2 / 0.683
4gyi ADPUncharacterized protein / 0.683
4jrn ANPRhoptry kinase family protein / 0.683
5eg3 ACPFibroblast growth factor receptor 2 / 0.682
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.681
2pup ADPMethylthioribose kinase 2.7.1.100 0.680
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.680
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.679
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.678
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.677
4nm0 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.677
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.675
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.675
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.674
3akl ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.674
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.674
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.674
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.674
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.672
1u54 ACPActivated CDC42 kinase 1 / 0.672
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.672
3c4x ATPRhodopsin kinase / 0.672
3nie ANPMitogen-activated protein kinase / 0.672
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.671
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.671
1ol7 ADPAurora kinase A 2.7.11.1 0.670
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.670
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.670
4fg8 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.670
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.670
5dnr ATPAurora kinase A 2.7.11.1 0.670
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.668
2pyw ADPMethylthioribose kinase 2.7.1.100 0.668
4o4e ATPKinase / 0.667
4ock ANPN-acetylhexosamine 1-kinase 2.7.1.162 0.667
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.666
3dnt ATPSerine/threonine-protein kinase toxin HipA / 0.665
4qny ANPMitogen activated protein kinase, putative / 0.665
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.665
5l8k ADPAurora kinase A 2.7.11.1 0.665
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.664
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.664
2pz5 ACPFibroblast growth factor receptor 2 / 0.663
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.662
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.662
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.662
3a7h ATPSerine/threonine-protein kinase 24 2.7.11.1 0.662
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.662
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.662
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.661
4o4f ATPKinase / 0.661
5iqb GNPBifunctional AAC/APH 2.3.1 0.661
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.660
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.659
3a7j ADPSerine/threonine-protein kinase 24 2.7.11.1 0.658
3orp AGSSerine/threonine protein kinase / 0.658
5iqi GNPBifunctional AAC/APH 2.3.1 0.658
2vqd AP2Biotin carboxylase 6.3.4.14 0.657
4aw0 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.657
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.656
2qoq ANPEphrin type-A receptor 3 2.7.10.1 0.656
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.656
4zgn ATPCell division cycle protein 123 / 0.656
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.655
2xan ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.654
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.654
4xx9 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.654
1fq1 ATPCyclin-dependent kinase 2 2.7.11.22 0.653
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.653
4o4d ATPKinase / 0.653
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.652
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.652
4rrv ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.652
4fl3 ANPTyrosine-protein kinase SYK 2.7.10.2 0.651
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.650