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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4f08 1RS Tyrosine-protein kinase JAK2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4f08 1RSTyrosine-protein kinase JAK2 / 0.811
4f09 JAKTyrosine-protein kinase JAK2 / 0.773
4e6q 0NVTyrosine-protein kinase JAK2 / 0.757
4ivb 1J5Tyrosine-protein kinase JAK1 / 0.746
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e4l 0NHTyrosine-protein kinase JAK1 / 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4iva 1J5Tyrosine-protein kinase JAK2 / 0.730
2ym3 YM3Serine/threonine-protein kinase Chk1 2.7.11.1 0.729
4ivc 1J6Tyrosine-protein kinase JAK1 / 0.729
4ei4 0Q2Tyrosine-protein kinase JAK1 / 0.728
4e4n 0NLTyrosine-protein kinase JAK1 / 0.714
3zls 92PDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.712
3zm4 22TDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.697
4e6d 0NUTyrosine-protein kinase JAK2 / 0.697
4i5c C5ITyrosine-protein kinase JAK1 / 0.684
4e4m 0NHTyrosine-protein kinase JAK2 / 0.675
1jpa ANPEphrin type-B receptor 2 2.7.10.1 0.671
1qpd STUTyrosine-protein kinase Lck 2.7.10.2 0.666
1aq1 STUCyclin-dependent kinase 2 2.7.11.22 0.664
2erz HFScAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.663
2cgw 3C3Serine/threonine-protein kinase Chk1 2.7.11.1 0.661
2pzr ACPFibroblast growth factor receptor 2 / 0.661
4e5f 0N7Polymerase acidic protein / 0.660
4jq8 KJ8Epidermal growth factor receptor 2.7.10.1 0.660
2z7q ACPRibosomal protein S6 kinase alpha-1 2.7.11.1 0.659
4ft7 H3KSerine/threonine-protein kinase Chk1 2.7.11.1 0.659
4fk6 0UJTyrosine-protein kinase JAK1 / 0.656