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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4e6q 0NV Tyrosine-protein kinase JAK2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4e6q 0NVTyrosine-protein kinase JAK2 / 0.836
4f08 1RSTyrosine-protein kinase JAK2 / 0.757
4e5w 0NTTyrosine-protein kinase JAK1 / 0.748
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4ivd 15TTyrosine-protein kinase JAK1 / 0.734
4iva 1J5Tyrosine-protein kinase JAK2 / 0.721
4ei4 0Q2Tyrosine-protein kinase JAK1 / 0.718
4e4l 0NHTyrosine-protein kinase JAK1 / 0.717
4fk6 0UJTyrosine-protein kinase JAK1 / 0.695
4ivc 1J6Tyrosine-protein kinase JAK1 / 0.691
2ym3 YM3Serine/threonine-protein kinase Chk1 2.7.11.1 0.686
1jpa ANPEphrin type-B receptor 2 2.7.10.1 0.685
4gii 0X6Non-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.663
2j0j 4STFocal adhesion kinase 1 2.7.10.2 0.661
4e5f 0N7Polymerase acidic protein / 0.660
2vgo AD5Aurora kinase B-A 2.7.11.1 0.657
2z7q ACPRibosomal protein S6 kinase alpha-1 2.7.11.1 0.656
2erz HFScAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.655
4f09 JAKTyrosine-protein kinase JAK2 / 0.655
2wmx ZY6Serine/threonine-protein kinase Chk1 2.7.11.1 0.651