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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4cr8 NAD N-acylmannosamine 1-dehydrogenase 1.1.1.233

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4cr8 NADN-acylmannosamine 1-dehydrogenase 1.1.1.233 0.860
4idg NADPutative UDP-glucose 4-epimerase / 0.756
2c59 NADGDP-mannose 3,5-epimerase 5.1.3.18 0.717
3rfx NADUronate dehydrogenase / 0.710
4yr9 NADL-threonine 3-dehydrogenase, mitochondrial 1.1.1.103 0.708
1n2s NAIdTDP-4-dehydrorhamnose reductase 1.1.1.133 0.706
3icp NADNAD-dependent epimerase/dehydratase / 0.704
2dkn NAI3-alpha-hydroxysteroid dehydrogenase / 0.695
1zem NADXylitol dehydrogenase / 0.692
4ros APRMalate dehydrogenase / 0.692
4u7w NDPMxaA / 0.692
1pzg A3DLactate dehydrogenase / 0.691
4id9 NADPutative UDP-glucose 4-epimerase / 0.690
1pzh NADLactate dehydrogenase / 0.687
1rkx NADCDP-D-glucose-4,6-dehydratase / 0.685
1i2b NADUDP-sulfoquinovose synthase, chloroplastic 3.13.1.1 0.679
1t2d NADL-lactate dehydrogenase 1.1.1.27 0.679
2vhz NAIAlanine dehydrogenase 1.4.1.1 0.679
2x0i NAIMalate dehydrogenase / 0.674
5a1t NAIL-lactate dehydrogenase / 0.674
3qvs NADMyo-inositol-1-phosphate synthase (Ino1) / 0.673
4hxy NDPPlm1 / 0.672
2c54 NADGDP-mannose 3,5-epimerase 5.1.3.18 0.670
3oa2 NADUDP-N-acetyl-2-amino-2-deoxy-D-glucuronate oxidase / 0.670
2fn7 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.669
1b2l NDCAlcohol dehydrogenase 1.1.1.1 0.668
2bgm NAJSecoisolariciresinol dehydrogenase 1.1.1.331 0.667
3ec7 NADInositol 2-dehydrogenase / 0.667
3uxy NADShort-chain dehydrogenase/reductase SDR / 0.667
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.667
1dhr NADDihydropteridine reductase 1.5.1.34 0.665
2q1t NADPutative nucleotide sugar epimerase/ dehydratase / 0.665
3rj9 NADAlcohol dehydrogenase 1.1.1.1 0.665
2ggs NDPdTDP-4-dehydrorhamnose reductase / 0.664
4yac NAIC alpha-dehydrogenase / 0.664
3ru9 NADUDP-N-acetylglucosamine 4-epimerase / 0.663
3adp NAILambda-crystallin 1.1.1.45 0.662
3gvi ADPMalate dehydrogenase / 0.662
2yy7 NADL-threonine dehydrogenase / 0.661
1nai NADUDP-glucose 4-epimerase 5.1.3.2 0.659
3qvw NADMyo-inositol-1-phosphate synthase (Ino1) / 0.659
1b16 NAQAlcohol dehydrogenase 1.1.1.1 0.658
2vyn NADGlyceraldehyde-3-phosphate dehydrogenase A / 0.658
3aw9 NADNAD-dependent epimerase/dehydratase / 0.658
3ruf NADUDP-N-acetylglucosamine 4-epimerase / 0.658
4o0l NDPNADPH-dependent 3-quinuclidinone reductase / 0.658
3n7u NADFormate dehydrogenase, chloroplastic/mitochondrial / 0.657
1jnr FADAdenylylsulfate reductase, subunit A (AprA) / 0.656
1npt NADGlyceraldehyde-3-phosphate dehydrogenase / 0.656
1nqa NADGlyceraldehyde-3-phosphate dehydrogenase / 0.656
2fje FADAdenylylsulfate reductase, subunit A (AprA) / 0.656
3abi NADUncharacterized protein / 0.656
3cmc NADGlyceraldehyde-3-phosphate dehydrogenase / 0.656
3g5s FADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO / 0.656
2pzj NADPutative nucleotide sugar epimerase/ dehydratase / 0.655
3d64 NADAdenosylhomocysteinase / 0.655
4lk3 NADUDP-glucuronic acid decarboxylase 1 4.1.1.35 0.655
1j5p NADL-aspartate dehydrogenase 1.4.1.21 0.654
1sc6 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.654
1t2a NDPGDP-mannose 4,6 dehydratase 4.2.1.47 0.654
2g76 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.654
3ggg NADPrephenate dehydrogenase / 0.654
3oet NADErythronate-4-phosphate dehydrogenase / 0.654
4k6f NAPPutative Acetoacetyl-CoA reductase / 0.654
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.653
1u7h NADPutative ornithine cyclodeaminase / 0.653
2ekl NADD-3-phosphoglycerate dehydrogenase / 0.653
2fjb SFDAdenylylsulfate reductase, subunit A (AprA) / 0.653
2fjd SFDAdenylylsulfate reductase, subunit A (AprA) / 0.653
2wsb NADGalactitol dehydrogenase / 0.653
2x0r NADMalate dehydrogenase / 0.653
4lsm NADGlyceraldehyde-3-phosphate dehydrogenase / 0.653
1t2c NAIL-lactate dehydrogenase 1.1.1.27 0.652
2nad NADFormate dehydrogenase / 0.652
3a4v NADNDP-sugar epimerase / 0.652
3ikt NADRedox-sensing transcriptional repressor Rex / 0.652
3jyo NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.652
1b14 NADAlcohol dehydrogenase 1.1.1.1 0.651
2a94 AP0L-lactate dehydrogenase 1.1.1.27 0.651
2gsd NADFormate dehydrogenase / 0.651
2pv7 NADT-protein 1.3.1.12 0.651
3m2t NADProbable dehydrogenase / 0.651
3mje NDPAmphB / 0.651
3qv1 NADGlyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic 1.2.1.13 0.651
1mg5 NAIAlcohol dehydrogenase 1.1.1.1 0.650
1pjc NADAlanine dehydrogenase / 0.650
2vhw NAIAlanine dehydrogenase 1.4.1.1 0.650
3wmx NADNAD dependent epimerase/dehydratase / 0.650