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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4c05 SAH Protein arginine N-methyltransferase 6

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4c05 SAHProtein arginine N-methyltransferase 6 / 1.004
4c04 SFGProtein arginine N-methyltransferase 6 / 0.756
2zth SAMCatechol O-methyltransferase 2.1.1.6 0.736
4hc4 SAHProtein arginine N-methyltransferase 6 / 0.734
3b3f SAHHistone-arginine methyltransferase CARM1 / 0.719
1skm SAHModification methylase HhaI 2.1.1.37 0.713
4lwp SAHArginine N-methyltransferase, putative / 0.713
2y1x SAHHistone-arginine methyltransferase CARM1 / 0.712
2c7q SAHModification methylase HhaI 2.1.1.37 0.710
4qdk SAHMagnesium-protoporphyrin O-methyltransferase 2.1.1.11 0.708
4qpp SAHProtein arginine N-methyltransferase 6 / 0.703
5dwq SFGHistone-arginine methyltransferase CARM1 / 0.700
4r6x SAHPhosphoethanolamine N-methyltransferase / 0.696
2yqz SAMUncharacterized protein / 0.695
5dx8 SFGHistone-arginine methyltransferase CARM1 / 0.695
2hnk SAHSAM-dependent O-methyltransferase / 0.694
3mht SAHModification methylase HhaI 2.1.1.37 0.694
7mht SAHModification methylase HhaI 2.1.1.37 0.693
3ldf SAHUncharacterized protein / 0.690
1ori SAHProtein arginine N-methyltransferase 1 / 0.688
5dxj SFGHistone-arginine methyltransferase CARM1 / 0.688
4c03 SFGProtein arginine N-methyltransferase 6 / 0.686
4iv8 SAMPhosphoethanolamine N-methyltransferase,putative / 0.686
4ymg SAMPutative SAM-dependent O-methyltranferase / 0.685
2cdu ADPNADH oxidase / 0.684
2y1w SFGHistone-arginine methyltransferase CARM1 / 0.682
3u81 SAHCatechol O-methyltransferase 2.1.1.6 0.682
4pyn SAHCatechol O-methyltransferase 2.1.1.6 0.682
3a25 SAMtRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase / 0.680
5dst SAHProtein arginine N-methyltransferase 8 2.1.1 0.679
2zcj SAHModification methylase HhaI 2.1.1.37 0.678
3duw SAHO-methyltransferase, putative / 0.678
3ou2 SAHSAM-dependent methyltransferase / 0.677
5dxa SFGHistone-arginine methyltransferase CARM1 / 0.677
5e72 SAMN2, N2-dimethylguanosine tRNA methyltransferase / 0.676
2i9k SAHModification methylase HhaI 2.1.1.37 0.673
4dcm SAMRibosomal RNA large subunit methyltransferase G 2.1.1.174 0.673
2z6u SAHModification methylase HhaI 2.1.1.37 0.672
4mwz SAMPhosphoethanolamine N-methyltransferase, putative / 0.671
3dlc SAMSAM (And some other nucleotide) binding motif:Generic methyltransferase / 0.670
4iv0 SAMPhosphoethanolamine N-methyltransferase, putative / 0.670
2yx1 SFGtRNA (guanine(37)-N1)-methyltransferase Trm5b 2.1.1.228 0.669
4pyo SAHCatechol O-methyltransferase 2.1.1.6 0.669
2qe6 SAMUncharacterized protein / 0.667
5ccb SAHtRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A 2.1.1.220 0.667
2uyh SAHModification methylase HhaI 2.1.1.37 0.665
3lcc SAHThiocyanate methyltransferase 1 / 0.665
3uj7 SAMPhosphoethanolamine N-methyltransferase / 0.665
4b69 FADL-ornithine N(5)-monooxygenase / 0.665
3grv ADNProbable ribosomal RNA small subunit methyltransferase A / 0.664
4nec SAHPutative SAM-dependent methyltransferase / 0.664
5e9w SAHmRNA cap guanine-N7 methyltransferase 2.1.1.56 0.664
3epp SFGmRNA cap guanine-N7 methyltransferase 2.1.1.56 0.663
3go4 SAHUncharacterized protein / 0.663
1i9g SAMtRNA (adenine(58)-N(1))-methyltransferase TrmI / 0.662
3iv6 SAMUncharacterized protein / 0.662
5dx1 SFGHistone-arginine methyltransferase CARM1 / 0.662
3lbf SAHProtein-L-isoaspartate O-methyltransferase 2.1.1.77 0.661
1nw5 SAMModification methylase RsrI 2.1.1.72 0.660
4fgz SAHPhosphoethanolamine N-methyltransferase / 0.659
2bzg SAHThiopurine S-methyltransferase 2.1.1.67 0.658
3v97 SAHRibosomal RNA large subunit methyltransferase K/L 2.1.1.173 0.658
3wdm ADN4-phosphopantoate--beta-alanine ligase 6.3.2.36 0.658
2br5 SAHCephalosporin hydroxylase CmcI / 0.657
3a26 MTAtRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase / 0.657
3cbg SAHO-methyltransferase / 0.657
3uj8 SFGPhosphoethanolamine N-methyltransferase / 0.657
5epe SAHUncharacterized protein / 0.657
5e8j SAHmRNA cap guanine-N7 methyltransferase 2.1.1.56 0.656
3c3y SAHO-methyltransferase / 0.655
4krh SAMPhosphoethanolamine N-methyltransferase 2 / 0.654
1qzz SAMAclacinomycin 10-hydroxylase RdmB 4.1.1 0.653
3nwe 662Catechol O-methyltransferase 2.1.1.6 0.653
3sso SAHMycinamicin VI 2''-O-methyltransferase / 0.653
5fa5 MTAProtein arginine N-methyltransferase 5 / 0.653
2p35 SAHTrans-aconitate 2-methyltransferase / 0.652
4oa5 SAHO-methyltransferase family protein / 0.652
1n4u FAECholesterol oxidase 1.1.3.6 0.650
2nxe SAMRibosomal protein L11 methyltransferase 2.1.1 0.650
3cnj FADCholesterol oxidase 1.1.3.6 0.650
3sr4 TT8Histone-lysine N-methyltransferase, H3 lysine-79 specific 2.1.1.43 0.650
4dmg SAMUncharacterized protein / 0.650
4m37 SAHProtein arginine N-methyltransferase 7 2.1.1 0.650
5eku SAHArginine N-methyltransferase, putative / 0.650