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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4bui W2E Tankyrase-2 2.4.2.30

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4bui W2ETankyrase-2 2.4.2.30 0.930
4buf F36Tankyrase-2 2.4.2.30 0.861
4bue JQFTankyrase-2 2.4.2.30 0.845
4buw F33Tankyrase-2 2.4.2.30 0.837
4bud 29FTankyrase-2 2.4.2.30 0.836
4buu F38Tankyrase-2 2.4.2.30 0.836
4but 31FTankyrase-2 2.4.2.30 0.835
4bu9 08CTankyrase-2 2.4.2.30 0.830
4buv 16ITankyrase-2 2.4.2.30 0.830
4bus 32FTankyrase-2 2.4.2.30 0.829
5aku 29FTankyrase-2 2.4.2.30 0.829
4bux F35Tankyrase-2 2.4.2.30 0.828
4l09 1URTankyrase-2 2.4.2.30 0.824
4l10 A63Tankyrase-2 2.4.2.30 0.816
4l0s 1UZTankyrase-2 2.4.2.30 0.810
4hlh 20DTankyrase-2 2.4.2.30 0.807
4l34 1VGTankyrase-2 2.4.2.30 0.804
4bs4 A64Tankyrase-2 2.4.2.30 0.803
4l0v 1V1Tankyrase-2 2.4.2.30 0.802
4l31 F08Tankyrase-2 2.4.2.30 0.802
4kzu A73Tankyrase-2 2.4.2.30 0.800
4l0i 1UWTankyrase-2 2.4.2.30 0.795
3kr8 XAVTankyrase-2 2.4.2.30 0.794
4hlm 16STankyrase-2 2.4.2.30 0.792
4l0t 1V0Tankyrase-2 2.4.2.30 0.792
4l33 F70Tankyrase-2 2.4.2.30 0.792
4hlk 431Tankyrase-2 2.4.2.30 0.789
4hki FLNTankyrase-2 2.4.2.30 0.788
4kzl 20DTankyrase-2 2.4.2.30 0.785
4l2k 1V8Tankyrase-2 2.4.2.30 0.782
4hlf 15ZTankyrase-2 2.4.2.30 0.779
4avw G18Tankyrase-2 2.4.2.30 0.774
4l32 1VFTankyrase-2 2.4.2.30 0.772
4hlg 20BTankyrase-2 2.4.2.30 0.768
4hmh F94Tankyrase-2 2.4.2.30 0.765
4hkk AGITankyrase-2 2.4.2.30 0.763
4hl5 15WTankyrase-2 2.4.2.30 0.757
4hkn LU2Tankyrase-2 2.4.2.30 0.756
4l2f 1V3Tankyrase-2 2.4.2.30 0.755
4l2g 1V4Tankyrase-2 2.4.2.30 0.750
4avu LDRTankyrase-2 2.4.2.30 0.733
4bjb P34Tankyrase-2 2.4.2.30 0.730
4msg 2C6Tankyrase-1 2.4.2.30 0.724
3u9y 09LTankyrase-2 2.4.2.30 0.707
4pnr G18Tankyrase-2 2.4.2.30 0.707
4pnm NU1Tankyrase-2 2.4.2.30 0.704
4li6 1XOTankyrase-1 2.4.2.30 0.703
4tjy 3GNTankyrase-2 2.4.2.30 0.701
4gv0 8MEPoly [ADP-ribose] polymerase 3 2.4.2.30 0.697
4gv2 5MEPoly [ADP-ribose] polymerase 3 2.4.2.30 0.697
3c4h DRLPoly [ADP-ribose] polymerase 3 2.4.2.30 0.693
4gv4 MEJPoly [ADP-ribose] polymerase 3 2.4.2.30 0.691
4gv7 MEWPoly [ADP-ribose] polymerase 1 2.4.2.30 0.690
4r5w XAVPoly [ADP-ribose] polymerase 1 2.4.2.30 0.688
4msk 2C8Tankyrase-1 2.4.2.30 0.681
4bjc RPBTankyrase-2 2.4.2.30 0.679
3gn7 3GNPoly [ADP-ribose] polymerase 1 2.4.2.30 0.676
3p0p NNFTankyrase-2 2.4.2.30 0.674
4tkg 09LTankyrase-2 2.4.2.30 0.672
4bj9 UHBTankyrase-2 2.4.2.30 0.667
3c49 KU8Poly [ADP-ribose] polymerase 3 2.4.2.30 0.662
4j22 AJ7Tankyrase-2 2.4.2.30 0.657
5ds3 09LPoly [ADP-ribose] polymerase 1 2.4.2.30 0.657
4j3l AJ5Tankyrase-2 2.4.2.30 0.656
5ewk P34Putative secreted protein / 0.656
3l3m A92Poly [ADP-ribose] polymerase 1 2.4.2.30 0.655
4j3i 1K0Bromodomain-containing protein 4 / 0.654
4hhz 15SPoly [ADP-ribose] polymerase 1 2.4.2.30 0.652