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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4b8l A0P Aurora kinase B-A 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4b8l A0PAurora kinase B-A 2.7.11.1 0.833
5l8k ADPAurora kinase A 2.7.11.1 0.693
3b2t M33Fibroblast growth factor receptor 2 / 0.689
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.680
2pmi AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.676
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.676
1e1v CMGCyclin-dependent kinase 2 2.7.11.22 0.673
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.673
4eom ATPCyclin-dependent kinase 2 2.7.11.22 0.669
3dqw AGSProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.667
3nyn SGVG protein-coupled receptor kinase 6 2.7.11.16 0.666
3hzi ATPSerine/threonine-protein kinase toxin HipA / 0.664
4c3r ACPAurora kinase A 2.7.11.1 0.664
2pvr ANPCasein kinase II subunit alpha 2.7.11.1 0.658
5l8j ADPAurora kinase A 2.7.11.1 0.658
2wqe ADPAurora kinase A 2.7.11.1 0.656
4c2w ANPAurora kinase B-A 2.7.11.1 0.656
2acx ANPG protein-coupled receptor kinase 6 2.7.11.16 0.655
2qo9 ANPEphrin type-A receptor 3 2.7.10.1 0.655
4s34 ANPMitogen-activated protein kinase 1 2.7.11.24 0.654
3mvj XFEcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.653
3ung ADPCRISPR system Cmr subunit Cmr2 / 0.653
1jpa ANPEphrin type-B receptor 2 2.7.10.1 0.651
2pup ADPMethylthioribose kinase 2.7.1.100 0.651
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.651
4ogr ADNCyclin-dependent kinase 9 2.7.11.22 0.650