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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3v36 NAP Aldose reductase 1.1.1.21

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3v36 NAPAldose reductase 1.1.1.21 1.581
2iq0 NAPAldose reductase 1.1.1.21 1.533
1x96 NAPAldose reductase 1.1.1.21 1.517
2acq NAPAldose reductase 1.1.1.21 1.500
3q67 NAPAldose reductase 1.1.1.21 1.498
1x98 NAPAldose reductase 1.1.1.21 1.488
1ads NAPAldose reductase 1.1.1.21 1.486
2pev NDPAldose reductase 1.1.1.21 1.484
2pf8 NDPAldose reductase 1.1.1.21 1.484
1z8a NAPAldose reductase 1.1.1.21 1.470
2j8t NAPAldose reductase 1.1.1.21 1.469
2acs NAPAldose reductase 1.1.1.21 1.467
2acu NAPAldose reductase 1.1.1.21 1.458
1ah4 NAPAldose reductase 1.1.1.21 1.396
3q65 NAPAldose reductase 1.1.1.21 1.387
2pfh NDPAldose reductase 1.1.1.21 1.325
3h7u NAPNADPH-dependent aldo-keto reductase, chloroplastic / 1.245
1ef3 NAPAldose reductase 1.1.1.21 1.237
3o3r NAPAldose reductase-related protein 1 1.1.1.21 1.231
2bgs NDPAldose reductase 1.1.1.21 1.206
3qkz NAPAldose reductase-related protein 1 1.1.1.21 1.197
4pmj NAPPutative oxidoreductase / 1.179
5c7h NDPPutative oxidoreductase / 1.159
4g5d NDPProstaglandin F synthase 1.1.1.188 1.152
1az2 NAPAldose reductase 1.1.1.21 1.137
2vdg NDPAldose reductase 1.1.1.21 1.129
1q5m NDPProstaglandin-E(2) 9-reductase 1.1.1.189 1.125
4ijr NDPD-arabinose dehydrogenase [NAD(P)+] heavy chain 1.1.1.117 1.113
3h7r NAPAldo-keto reductase family 4 member C8 / 1.083
4xzn NAPAldo-keto reductase family 1 member B10 1.1.1 1.063
3bv7 NAP3-oxo-5-beta-steroid 4-dehydrogenase / 1.060
3uzw NAP3-oxo-5-beta-steroid 4-dehydrogenase / 1.044
3g1r NAP3-oxo-5-beta-steroid 4-dehydrogenase / 1.021
1k8c NAPNAD(P)H-dependent D-xylose reductase 1.1.1.307 1.010
1hqt NAPAlcohol dehydrogenase [NADP(+)] 1.1.1.2 1.000
4xo7 NAPAldo-keto reductase family 1 member C2 / 0.992
4xzm NAPAldo-keto reductase family 1 member B10 1.1.1 0.990
3wbw NDPPutative 2,5-diketo-D-gluconic acid reductase / 0.968
1a80 NDP2,5-diketo-D-gluconic acid reductase A 1.1.1.346 0.956
3dop NAP3-oxo-5-beta-steroid 4-dehydrogenase / 0.934
4jq3 NAPAldo-keto reductase family 1 member C2 / 0.929
3caq NDP3-oxo-5-beta-steroid 4-dehydrogenase / 0.927
4jtq NAPAldo-keto reductase family 1 member C2 / 0.911
1vp5 NAPOxidoreductase, aldo/keto reductase family / 0.910
3wcz NAPAldo-keto reductase AKR2E4 / 0.910
1s1r NAPAldo-keto reductase family 1 member C3 / 0.908
3buv NAP3-oxo-5-beta-steroid 4-dehydrogenase / 0.900
4dz5 NAPAldo-keto reductase family 1 member C3 / 0.898
1r38 NAPNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.889
1c9w NAPAldose reductase-related protein 2 / 0.887
2fvl NAPAldo-keto reductase family 1 member C4 1.1.1.225 0.880
1zgd NAPChalcone reductase / 0.878
2hdj NDPAldo-keto reductase family 1 member C2 / 0.877
1s1p NAPAldo-keto reductase family 1 member C3 / 0.859
1mi3 NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.855
1ye4 NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.832
1m9h NAD2,5-diketo-D-gluconic acid reductase A 1.1.1.346 0.820
1gve NAPAflatoxin B1 aldehyde reductase member 3 1 0.815
4l1x NAPAldo-keto reductase family 1 member C2 / 0.799
1sm9 NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.785
1ye6 NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.776
1z9a NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.765
3ln3 NADAldo-keto reductase family 1 member C13 / 0.742
4h8n NDPNADPH-dependent conjugated polyketone reductase C2 / 0.724
2p5n NDPAldo-keto reductase family 1 member C21 1.1.1 0.718
2bp1 NDPAflatoxin B1 aldehyde reductase member 2 / 0.701
1lwi NAP3-alpha-hydroxysteroid dehydrogenase 1.1.1.50 0.694
2c91 NAPAflatoxin B1 aldehyde reductase member 2 / 0.687
3wg6 NDPNADPH-dependent conjugated polyketone reductase C1 / 0.683
1ye6 NAPNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.681
1og6 NAPOxidoreductase YdhF 1 0.680
2clp NDPAflatoxin B1 aldehyde reductase member 3 / 0.673
2he5 NDPAldo-keto reductase family 1 member C21 1.1.1 0.671
2hej NDPAldo-keto reductase family 1 member C21 1.1.1 0.669
4jtd NAPVoltage-gated potassium channel subunit beta-2 / 0.659
4gyy 12VUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit / 0.650