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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3sw4 18K Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3sw4 18KCyclin-dependent kinase 2 2.7.11.22 0.969
4fko 20KCyclin-dependent kinase 2 2.7.11.22 0.956
3sw7 19KCyclin-dependent kinase 2 2.7.11.22 0.899
2xnb Y8LCyclin-dependent kinase 2 2.7.11.22 0.782
1pxm CK5Cyclin-dependent kinase 2 2.7.11.22 0.772
1pxp CK8Cyclin-dependent kinase 2 2.7.11.22 0.747
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4bgh 3I6Cyclin-dependent kinase 2 2.7.11.22 0.742
4ek8 16KCyclin-dependent kinase 2 2.7.11.22 0.734
2xmy CDKCyclin-dependent kinase 2 2.7.11.22 0.728
3cjg KIMVascular endothelial growth factor receptor 2 2.7.10.1 0.722
1urw I1PCyclin-dependent kinase 2 2.7.11.22 0.721
1pxl CK4Cyclin-dependent kinase 2 2.7.11.22 0.717
4aot GW8Serine/threonine-protein kinase 10 2.7.11.1 0.712
2w06 FRVCyclin-dependent kinase 2 2.7.11.22 0.707
2c5n CK8Cyclin-dependent kinase 2 2.7.11.22 0.697
4bbf O19Tyrosine-protein kinase JAK2 / 0.686
4d58 BI9Focal adhesion kinase 1 2.7.10.2 0.684
2c5y MTWCyclin-dependent kinase 2 2.7.11.22 0.681
4bcq TJFCyclin-dependent kinase 2 2.7.11.22 0.681
1pxo CK7Cyclin-dependent kinase 2 2.7.11.22 0.678
4ek6 10KCyclin-dependent kinase 2 2.7.11.22 0.673
1m52 P17Tyrosine-protein kinase ABL1 2.7.10.2 0.671
3uli 1N3Cyclin-dependent kinase 2 2.7.11.22 0.670
3fzr 3JZProtein-tyrosine kinase 2-beta 2.7.10.2 0.667
3tiz 3TICyclin-dependent kinase 2 2.7.11.22 0.667
4iwq 1FVSerine/threonine-protein kinase TBK1 2.7.11.1 0.666
4c3f 7KWTyrosine-protein kinase Lck 2.7.10.2 0.665
3uo5 0BXAurora kinase A 2.7.11.1 0.664
3h3c P1EProtein-tyrosine kinase 2-beta 2.7.10.2 0.663
4e93 GUITyrosine-protein kinase Fes/Fps 2.7.10.2 0.663
4fkj 11KCyclin-dependent kinase 2 2.7.11.22 0.661
1gih 1PUCyclin-dependent kinase 2 2.7.11.22 0.658
2wxv WXVCyclin-dependent kinase 2 2.7.11.22 0.658
2jko BIJFocal adhesion kinase 1 2.7.10.2 0.657
2wih P48Cyclin-dependent kinase 2 2.7.11.22 0.657
3igg EFQCyclin-dependent kinase 2 2.7.11.22 0.657
2vti LZ3Cyclin-dependent kinase 2 2.7.11.22 0.656
4dea NHIAurora kinase A 2.7.11.1 0.654
1unh IXMCyclin-dependent-like kinase 5 2.7.11.1 0.653
3nux 3NVCyclin-dependent kinase 6 2.7.11.22 0.652
2xb7 GUIALK tyrosine kinase receptor 2.7.10.1 0.651