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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3q5i ANP Protein kinase, putative

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3q5i ANPProtein kinase, putative / 0.943
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.732
4qny ANPMitogen activated protein kinase, putative / 0.728
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.719
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.718
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.713
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.713
4y0x ADPSerine/threonine-protein kinase PknG 2.7.11.1 0.712
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.707
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.706
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.703
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.702
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.702
3qc9 ADPRhodopsin kinase / 0.702
2acx ANPG protein-coupled receptor kinase 6 2.7.11.16 0.699
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.698
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.698
5dr2 ATPAurora kinase A 2.7.11.1 0.698
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.697
1u54 ACPActivated CDC42 kinase 1 / 0.696
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.696
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.696
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.695
2pup ADPMethylthioribose kinase 2.7.1.100 0.691
4q4c ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.691
3c50 ADPRhodopsin kinase / 0.690
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.690
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.690
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.689
2olc ADPMethylthioribose kinase 2.7.1.100 0.689
3c4w ATPRhodopsin kinase / 0.689
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.687
3t9d ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.686
4utd ACPAurora kinase A 2.7.11.1 0.686
2pun ACPMethylthioribose kinase 2.7.1.100 0.685
3lij ANPCalcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands / 0.685
3t8o ATPRhodopsin kinase / 0.684
5eg3 ACPFibroblast growth factor receptor 2 / 0.684
3c4z ADPRhodopsin kinase / 0.683
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.683
3mfu ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.680
2pul ACPMethylthioribose kinase 2.7.1.100 0.679
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.679
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.678
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.678
1q99 ANPSerine/threonine-protein kinase SKY1 2.7.11.1 0.678
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.678
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.677
4xlv ACPInsulin receptor 2.7.10.1 0.677
1zao ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.675
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.674
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.673
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.673
2uw0 GVKcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.671
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.671
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.671
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.670
3dqw AGSProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.670
4fkl CK2Cyclin-dependent kinase 2 2.7.11.22 0.670
4y12 AGSSerine/threonine-protein kinase PknG 2.7.11.1 0.670
1jqh ANPInsulin-like growth factor 1 receptor 2.7.10.1 0.669
2ijm ATPFocal adhesion kinase 1 2.7.10.2 0.668
5dos ATPAurora kinase A 2.7.11.1 0.668
5drd ATPAurora kinase A 2.7.11.1 0.668
1ol6 ATPAurora kinase A 2.7.11.1 0.667
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.666
3a7j ADPSerine/threonine-protein kinase 24 2.7.11.1 0.666
4o4e ATPKinase / 0.666
4o4f ATPKinase / 0.666
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.665
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.665
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.664
3wnz ADPAlanine--anticapsin ligase / 0.663
2py3 ACPFibroblast growth factor receptor 2 / 0.662
2xkc 4VQSerine/threonine-protein kinase Nek2 2.7.11.1 0.662
3vjo ANPEpidermal growth factor receptor 2.7.10.1 0.662
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.662
1i44 ACPInsulin receptor 2.7.10.1 0.661
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.661
4ix5 ANPUncharacterized protein / 0.661
5dn3 ATPAurora kinase A 2.7.11.1 0.661
5dt4 ATPAurora kinase A 2.7.11.1 0.661
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.660
1tqp ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.660
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.660
3lct ADPALK tyrosine kinase receptor 2.7.10.1 0.659
3r5f ATPD-alanine--D-alanine ligase / 0.659
4dee ADPAurora kinase A 2.7.11.1 0.659
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.659
2pz5 ACPFibroblast growth factor receptor 2 / 0.658
2vo7 M05cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.658
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.658
1fin ATPCyclin-dependent kinase 2 2.7.11.22 0.657
2pzp ACPFibroblast growth factor receptor 2 / 0.657
1mq4 ADPAurora kinase A 2.7.11.1 0.656
2gs7 ANPEpidermal growth factor receptor 2.7.10.1 0.656
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.655
3t9f ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.655
4wzy ATPMaltokinase 2.7.1.175 0.655
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.654
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.654
4gt3 ATPMitogen-activated protein kinase 1 2.7.11.24 0.654
5dnr ATPAurora kinase A 2.7.11.1 0.654
1m0w ANPGlutathione synthetase 6.3.2.3 0.653
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.653
2pui ADPMethylthioribose kinase 2.7.1.100 0.653
3juh ANPCasein kinase II subunit alpha 2.7.11.1 0.653
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.652
3zxt ACPDeath-associated protein kinase 1 2.7.11.1 0.652
4ydu ADPtRNA N6-adenosine threonylcarbamoyltransferase / 0.652
1pxj CK2Cyclin-dependent kinase 2 2.7.11.22 0.651
4dsj DGTDNA polymerase I / 0.651
4wh2 ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.651
2qo9 ANPEphrin type-A receptor 3 2.7.10.1 0.650
4f1o ACPProbable serine/threonine-protein kinase roco4 2.7.11.1 0.650