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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3hvk 719 Catechol O-methyltransferase 2.1.1.6

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3hvk 719Catechol O-methyltransferase 2.1.1.6 1.322
3hvi 619Catechol O-methyltransferase 2.1.1.6 1.198
3nwb 659Catechol O-methyltransferase 2.1.1.6 1.159
3nw9 637Catechol O-methyltransferase 2.1.1.6 1.073
3r6t LU1Catechol O-methyltransferase 2.1.1.6 1.018
3nwe 662Catechol O-methyltransferase 2.1.1.6 0.936
1jr4 CL4Catechol O-methyltransferase 2.1.1.6 0.914
3oe4 610Catechol O-methyltransferase 2.1.1.6 0.872
3ozs OZSCatechol O-methyltransferase 2.1.1.6 0.864
3oe5 611Catechol O-methyltransferase 2.1.1.6 0.862
3ozt OZZCatechol O-methyltransferase 2.1.1.6 0.854
3a7d FBNCatechol O-methyltransferase 2.1.1.6 0.838
3ozr OZRCatechol O-methyltransferase 2.1.1.6 0.801
2zth SAMCatechol O-methyltransferase 2.1.1.6 0.741
2zvj KOMCatechol O-methyltransferase 2.1.1.6 0.739
4ymg SAMPutative SAM-dependent O-methyltranferase / 0.734
3u81 SAHCatechol O-methyltransferase 2.1.1.6 0.727
4pyn SAHCatechol O-methyltransferase 2.1.1.6 0.726
5fhq DNCCatechol O-methyltransferase 2.1.1.6 0.724
5ccb SAHtRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A 2.1.1.220 0.714
3duw SAHO-methyltransferase, putative / 0.703
4oa5 SAHO-methyltransferase family protein / 0.702
5ccx SAHtRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A 2.1.1.220 0.702
2yqz SAMUncharacterized protein / 0.697
3bgi SAHThiopurine S-methyltransferase 2.1.1.67 0.697
4nec SAHPutative SAM-dependent methyltransferase / 0.691
1l3i SAHProbable cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating) / 0.690
3bwc SAMSpermidine synthase, putative / 0.684
1y8q ATPSUMO-activating enzyme subunit 2 6.3.2 0.683
2p35 SAHTrans-aconitate 2-methyltransferase / 0.682
4txi FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.682
3ou6 SAMSAM-dependent methyltransferase / 0.680
2c7g FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.679
3g07 SAM7SK snRNA methylphosphate capping enzyme 2.1.1 0.679
4tm1 FDAKtzI / 0.678
4yuz S4MSpermidine synthase, putative / 0.678
3lcc SAHThiocyanate methyltransferase 1 / 0.677
4xvy SAHMycinamicin III 3''-O-methyltransferase 2.1.1.237 0.677
4tlx FDAKtzI / 0.676
2fjd SFDAdenylylsulfate reductase, subunit A (AprA) / 0.675
3ou2 SAHSAM-dependent methyltransferase / 0.675
4x7y SAHMycinamicin III 3''-O-methyltransferase 2.1.1.237 0.675
2fjb SFDAdenylylsulfate reductase, subunit A (AprA) / 0.674
4yac NAIC alpha-dehydrogenase / 0.674
4c04 SFGProtein arginine N-methyltransferase 6 / 0.673
4j2w FADKynurenine 3-monooxygenase / 0.671
1jnz FADAdenylylsulfate reductase, subunit A (AprA) / 0.670
1wy7 SAHUncharacterized protein / 0.670
3bg7 FADPyranose 2-oxidase / 0.668
3epp SFGmRNA cap guanine-N7 methyltransferase 2.1.1.56 0.668
3i0a DBHNeutrophil gelatinase-associated lipocalin / 0.668
3k4c FADPyranose 2-oxidase / 0.668
3lga SAHtRNA (adenine(57)-N(1)/adenine(58)-N(1))-methyltransferase TrmI 2.1.1.219 0.668
4kwc SAHMethyltransferase domain family / 0.668
4b69 FADL-ornithine N(5)-monooxygenase / 0.667
1bwc FADGlutathione reductase, mitochondrial 1.8.1.7 0.665
2cdu ADPNADH oxidase / 0.665
5hxw FADL-amino acid deaminase / 0.665
2vou FAD2,6-dihydroxypyridine 3-monooxygenase 1.14.13.10 0.664
3icr FADCoenzyme A disulfide reductase / 0.664
5bp9 SAHPutative methyltransferase protein / 0.664
3grr SAHProbable ribosomal RNA small subunit methyltransferase A / 0.663
7mht SAHModification methylase HhaI 2.1.1.37 0.663
4u2t FADCholesterol oxidase 1.1.3.6 0.662
5e9w SAHmRNA cap guanine-N7 methyltransferase 2.1.1.56 0.662
9mht SAHModification methylase HhaI 2.1.1.37 0.662
2eq8 FADDihydrolipoyl dehydrogenase / 0.661
3a26 MTAtRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase / 0.661
3ics FADCoenzyme A disulfide reductase / 0.661
3ict FADCoenzyme A disulfide reductase / 0.661
3v97 SAHRibosomal RNA large subunit methyltransferase K/L 2.1.1.173 0.661
4xcx SAHSmall RNA 2'-O-methyltransferase / 0.661
5eku SAHArginine N-methyltransferase, putative / 0.661
1n4v FADCholesterol oxidase 1.1.3.6 0.660
4m37 SAHProtein arginine N-methyltransferase 7 2.1.1 0.660
3a4t SFGtRNA (cytosine(48)-C(5))-methyltransferase 2.1.1 0.659
2bry FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.658
2jib ADPOxalyl-CoA decarboxylase 4.1.1.8 0.658
3g8a SAHRibosomal RNA small subunit methyltransferase G / 0.657
5bxy SAHPutative RNA methylase family UPF0020 / 0.657
3emd SFGMethyltransferase / 0.656
3ou7 SAMSAM-dependent methyltransferase / 0.654
4wec NADShort chain dehydrogenase / 0.654
1v59 NADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.653
1zmc NADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.653
4iv8 SAMPhosphoethanolamine N-methyltransferase,putative / 0.653
2bra FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.652
3k30 ADPHistamine dehydrogenase / 0.652
2c3k ABOSerine/threonine-protein kinase Chk1 2.7.11.1 0.651
4rvd SAMD-mycarose 3-C-methyltransferase / 0.651
1qo8 FADFumarate reductase flavoprotein subunit / 0.650
2c7q SAHModification methylase HhaI 2.1.1.37 0.650
2uyh SAHModification methylase HhaI 2.1.1.37 0.650
5e8j SAHmRNA cap guanine-N7 methyltransferase 2.1.1.56 0.650