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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3eo8 FMN Putative nitroreductase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3eo8 FMNPutative nitroreductase / 1.343
4qly FMNEnone reductase CLA-ER / 1.048
3gag FMNPutative NADH dehydrogenase NAD(P)H nitroreductase / 0.928
3ge6 FMNNitroreductase / 0.911
4ttb FMNIodotyrosine deiodinase 1 / 0.907
3e39 FMNNitroreductase / 0.881
3gfd FMNIodotyrosine deiodinase 1 1.21.1.1 0.880
3gh8 FMNIodotyrosine deiodinase 1 1.21.1.1 0.867
2bkj FMNNADPH-flavin oxidoreductase / 0.866
4ttc FMNIodotyrosine deiodinase 1 / 0.866
4xoo FMNCoenzyme F420:L-glutamate ligase / 0.854
2wzw FMNNitroreductase NfnB / 0.842
2wzv FMNNitroreductase NfnB / 0.839
2isk FNR5,6-dimethylbenzimidazole synthase 1.13.11.79 0.828
1oon FMNOxygen-insensitive NAD(P)H nitroreductase / 0.817
3koq FMNPutative nitroreductase / 0.812
1vfr FMNMajor NAD(P)H-flavin oxidoreductase 1.6.99 0.807
2isl FNR5,6-dimethylbenzimidazole synthase 1.13.11.79 0.801
1icv FMNOxygen-insensitive NAD(P)H nitroreductase / 0.799
3hj9 FMNUncharacterized protein / 0.792
1kqb FMNOxygen-insensitive NAD(P)H nitroreductase / 0.791
3x22 FMNOxygen-insensitive NAD(P)H nitroreductase / 0.788
2hay FMNPutative NAD(P)H-flavin oxidoreductase / 0.784
3eof FMNPutative oxidase / 0.769
3to0 FMNIodotyrosine deiodinase 1 1.21.1.1 0.764
3djl FADPutative acyl-CoA dehydrogenase AidB 1.3.99 0.763
3pxv FMNNitroreductase / 0.759
3bem FMNPutative NAD(P)H nitroreductase MhqN 1 0.755
1ooq FMNOxygen-insensitive NAD(P)H nitroreductase / 0.754
2ifa FMNUncharacterized protein / 0.749
3x21 FMNOxygen-insensitive NAD(P)H nitroreductase / 0.749
4p13 FADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial 1.3.8.7 0.745
1yki FMNOxygen-insensitive NAD(P)H nitroreductase / 0.741
4eo3 FMNBacterioferritin comigratory protein/NADH dehydrogenase / 0.738
3mdd FADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial 1.3.8.7 0.731
1ds7 FMNOxygen-insensitive NAD(P)H nitroreductase / 0.726
1jqi FADShort-chain specific acyl-CoA dehydrogenase, mitochondrial / 0.723
1nec FMNOxygen-insensitive NAD(P)H nitroreductase 1 0.721
1ylr FMNOxygen-insensitive NAD(P)H nitroreductase / 0.720
2isj FMN5,6-dimethylbenzimidazole synthase 1.13.11.79 0.717
2z1q FADAcyl-CoA dehydrogenase / 0.717
1oo5 FMNOxygen-insensitive NAD(P)H nitroreductase / 0.715
3u33 FADPutative acyl-CoA dehydrogenase AidB 1.3.99 0.715
3fcj FADNitroalkane oxidase 1.7.3.1 0.712
3of4 FMNNitroreductase / 0.711
2ohi FMNType A flavoprotein FprA 1 0.709
1ylu FMNOxygen-insensitive NAD(P)H nitroreductase / 0.707
1icu FMNOxygen-insensitive NAD(P)H nitroreductase / 0.706
3e4v FMNUncharacterized protein / 0.703
3in6 FMNUncharacterized protein / 0.702
3oib FDAPutative acyl-CoA dehydrogenase / 0.701
1d4a FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.699
3pft FMNFlavin reductase / 0.698
1buc FADAcyl-CoA dehydrogenase, short-chain specific 1.3.8.1 0.696
1eje FMNProtein MTH_152 / 0.696
2fcr FMNFlavodoxin / 0.695
1kqc FMNOxygen-insensitive NAD(P)H nitroreductase / 0.693
3mkh FADNitroalkane oxidase / 0.693
4hh0 FMNAppA protein / 0.692
4hhd FMNPhototropin-1 2.7.11.1 0.692
4iv6 FDAIsovaleryl-CoA dehydrogenase / 0.692
2byc FMNBlue-light receptor of the BLUF-family / 0.691
4y9l FADAcyl-CoA dehydrogenase family member 11 / 0.691
1kqd FMNOxygen-insensitive NAD(P)H nitroreductase / 0.690
1qbg FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.690
3p4t FAOPutative acyl-CoA dehydrogenase / 0.689
1cbo FADCholesterol oxidase 1.1.3.6 0.688
4zvn FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.688
2vig FADShort-chain specific acyl-CoA dehydrogenase, mitochondrial 1.3.8.1 0.686
2iyg FMNAppA, antirepressor of ppsR, sensor of blue light / 0.684
2d29 FADAcyl-CoA dehydrogenase / 0.682
4zvl FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.682
5fs7 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.682
2zbw FADFerredoxin--NADP reductase / 0.681
1b8s FADCholesterol oxidase 1.1.3.6 0.680
1gwj FMNMorphinone reductase / 0.680
1mxt FAECholesterol oxidase 1.1.3.6 0.680
1x31 FMNSubunit alpha of sarocosine oxidase / 0.680
1x31 FMNSubunit beta of sarcosine oxidase / 0.680
1n4v FADCholesterol oxidase 1.1.3.6 0.679
4rek FADCholesterol oxidase 1.1.3.6 0.679
1n4w FADCholesterol oxidase 1.1.3.6 0.677
3lsi FADPyranose 2-oxidase / 0.677
3a3b RBFLumazine protein / 0.676
2c12 FADNitroalkane oxidase 1.7.3.1 0.673
2gew FADCholesterol oxidase 1.1.3.6 0.673
2zaf FADNitroalkane oxidase 1.7.3.1 0.673
1yrx FMNAppA protein / 0.671
2b3d FADModulator of drug activity B / 0.671
1ep1 FMNDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit 1.3.1.14 0.668
1jeh FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.668
3jqr FADFerredoxin--NADP reductase, apicoplast / 0.667
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.665
1ps9 FAD2,4-dienoyl-CoA reductase 1.3.1.34 0.665
1vrq FMNSubunit alpha of sarocosine oxidase / 0.664
1vrq FMNSubunit beta of sarcosine oxidase / 0.664
4u2l SFDCholesterol oxidase 1.1.3.6 0.664
5cho FADFlavin reductase / 0.664
1a8p FADFerredoxin--NADP reductase / 0.663
2q3o FMN12-oxophytodienoate reductase 3 1.3.1.42 0.663
3v76 FDAUncharacterized protein / 0.663
4fk1 FADPutative thioredoxin reductase / 0.662
1gth FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.661
3k7m FAD6-hydroxy-L-nicotine oxidase / 0.661
1i0s FMNFerric-chelate reductase (NAD(P)H) / 0.660
1n4u FAECholesterol oxidase 1.1.3.6 0.659
4xwr FADCholesterol oxidase 1.1.3.6 0.659
1bwl FMNNADPH dehydrogenase 1 1.6.99.1 0.658
2fre FMNNAD(P)H-flavin oxidoreductase / 0.658
4xxg FADCholesterol oxidase 1.1.3.6 0.658
1ijh FADCholesterol oxidase 1.1.3.6 0.657
1x0p FADTll0078 protein / 0.657
2v0u FMNNPH1-1 / 0.657
2z6c FMNPhototropin-1 2.7.11.1 0.657
4uir FADOleate hydratase 4.2.1.53 0.657
2gr3 FADFerredoxin reductase / 0.656
2i51 FMNPyridoxamine 5'-phosphate oxidase-related, FMN-binding / 0.656
4w5k PLPAspartate aminotransferase, mitochondrial / 0.655
1ep3 FADDihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit / 0.654
2gqw FADFerredoxin reductase / 0.654
2jbs FMNp-hydroxyphenylacetate 3-hydroxylase, oxygenase component / 0.654
2qmy FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.654
4h4t FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.654
1efv FADElectron transfer flavoprotein subunit alpha, mitochondrial / 0.653
2ohj FMNType A flavoprotein FprA 1 0.653
2v5u FMNFlavodoxin / 0.653
3c3n FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.653
3n3b FMNProtein NrdI / 0.653
4h4x FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.653
4h4z FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.653
3qvr FADGlucose oxidase 1.1.3.4 0.652
4cw5 FMNDfnA / 0.651
4qoe FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.651
4u2s FDACholesterol oxidase 1.1.3.6 0.651
2jae FADL-amino acid oxidase / 0.650
3qdl FMNOxygen-insensitive NADPH nitroreductase / 0.650
5ez7 FADProbable FAD-dependent oxidoreductase PA4991 / 0.650