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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3cjf SAV Vascular endothelial growth factor receptor 2 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3cjf SAVVascular endothelial growth factor receptor 2 2.7.10.1 0.919
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
3bea IXHMacrophage colony-stimulating factor 1 receptor 2.7.10.1 0.724
3uo5 0BXAurora kinase A 2.7.11.1 0.708
4ji9 1M3Tyrosine-protein kinase JAK2 / 0.708
2xb7 GUIALK tyrosine kinase receptor 2.7.10.1 0.690
2xck MH43-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.689
4fko 20KCyclin-dependent kinase 2 2.7.11.22 0.688
2jkq VG8Focal adhesion kinase 1 2.7.10.2 0.685
2xch CKG3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.685
3cjg KIMVascular endothelial growth factor receptor 2 2.7.10.1 0.683
4dea NHIAurora kinase A 2.7.11.1 0.683
4hys 1BJMitogen-activated protein kinase 8 2.7.11.24 0.680
4b6l 9ZPSerine/threonine-protein kinase PLK3 2.7.11.21 0.679
4izy 1J2Mitogen-activated protein kinase 8 2.7.11.24 0.675
4bgh 3I6Cyclin-dependent kinase 2 2.7.11.22 0.674
1oir HDYCyclin-dependent kinase 2 2.7.11.22 0.664
2vgp AD6Aurora kinase B-A 2.7.11.1 0.664
1oec AA2Fibroblast growth factor receptor 2 / 0.662
4e5f 0N7Polymerase acidic protein / 0.660
4aot GW8Serine/threonine-protein kinase 10 2.7.11.1 0.656
1z5m LI83-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.654
2jko BIJFocal adhesion kinase 1 2.7.10.2 0.653
4d58 BI9Focal adhesion kinase 1 2.7.10.2 0.652
3tki S25Serine/threonine-protein kinase Chk1 2.7.11.1 0.651
2x1n X1NCyclin-dependent kinase 2 2.7.11.22 0.650
2yac 937Serine/threonine-protein kinase PLK1 2.7.11.21 0.650