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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2xaa NAD Secondary alcohol dehydrogenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2xaa NADSecondary alcohol dehydrogenase / 1.175
3jv7 NADSecondary alcohol dehydrogenase / 1.067
3wle NAD(R)-specific carbonyl reductase / 0.962
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.924
4c4o NADSADH / 0.900
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.896
4w6z 8IDAlcohol dehydrogenase 1 1.1.1.1 0.878
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 0.875
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 0.865
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 0.855
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.852
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.846
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.843
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.843
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.840
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 0.832
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 0.832
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 0.831
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 0.826
5env NADAlcohol dehydrogenase 1 1.1.1.1 0.816
3two NDPMannitol dehydrogenase / 0.813
1yqd NAPSinapyl alcohol dehydrogenase / 0.809
4oaq NDPR-specific carbonyl reductase / 0.807
5kj1 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.800
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 0.795
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.785
2eer NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.784
2jhf NADAlcohol dehydrogenase E chain 1.1.1.1 0.779
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 0.774
1adb CNDAlcohol dehydrogenase E chain 1.1.1.1 0.754
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 0.750
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.750
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 0.747
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 0.746
1uxj NADMalate dehydrogenase / 0.744
4rqu NADAlcohol dehydrogenase class-P / 0.744
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.743
1mp0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.741
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 0.733
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 0.728
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.724
3m6i NADL-arabinitol 4-dehydrogenase 1.1.1.12 0.720
4j43 NADUncharacterized protein / 0.720
1hdz NADAlcohol dehydrogenase 1B 1.1.1.1 0.717
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.717
2dfd NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.716
4i1i NADMalate dehydrogenase / 0.716
4jk3 NADUncharacterized protein / 0.716
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.713
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 0.708
1heu NADAlcohol dehydrogenase E chain 1.1.1.1 0.707
1teh NADAlcohol dehydrogenase class-3 1.1.1.1 0.707
1ma0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.705
1het NADAlcohol dehydrogenase E chain 1.1.1.1 0.703
2x0i NAIMalate dehydrogenase / 0.703
1ie3 NADMalate dehydrogenase / 0.702
1o6z NADMalate dehydrogenase / 0.702
1ib6 NADMalate dehydrogenase / 0.701
5mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.700
1u7h NADPutative ornithine cyclodeaminase / 0.699
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 0.699
1e3l NADAlcohol dehydrogenase 4 1.1.1.1 0.696
2vwh NAPGlucose 1-dehydrogenase / 0.696
1yqx NAPSinapyl alcohol dehydrogenase / 0.695
1pzh NADLactate dehydrogenase / 0.694
1uxk NADMalate dehydrogenase / 0.693
2voj NADAlanine dehydrogenase 1.4.1.1 0.691
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.691
4l0q NADAlcohol dehydrogenase class-3 / 0.690
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 0.689
4j49 NADUncharacterized protein / 0.689
4b7x NAPProbable oxidoreductase / 0.687
1il0 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.683
2vhz NAIAlanine dehydrogenase 1.4.1.1 0.683
1b8u NADMalate dehydrogenase / 0.682
1hld NADAlcohol dehydrogenase E chain 1.1.1.1 0.682
1x7d NADPutative ornithine cyclodeaminase / 0.682
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 0.680
1wze NADMalate dehydrogenase / 0.680
1llu NADAlcohol dehydrogenase / 0.679
1j5p NADL-aspartate dehydrogenase 1.4.1.21 0.678
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 0.678
4wlv NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.677
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.676
4cpd NADAlcohol dehydrogenase / 0.676
5a1t NAIL-lactate dehydrogenase / 0.675
1gv0 NADMalate dehydrogenase / 0.674
1p0f NAPNADP-dependent alcohol dehydrogenase 1.1.1.2 0.674
1m76 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.671
4nd2 A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.671
4mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.670
4gl4 NAIAlcohol dehydrogenase class-3 / 0.669
1pzg A3DLactate dehydrogenase / 0.667
4ejm NAPPutative zinc-binding dehydrogenase / 0.667
1f0y NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.666
1pl8 NADSorbitol dehydrogenase 1.1.1.14 0.666
4k28 NADShikimate dehydrogenase family protein / 0.666
4nd3 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.666
1la2 NADInositol-3-phosphate synthase 5.5.1.4 0.665
1f8f NADBenzyl alcohol dehydrogenase / 0.664
1piw NAPNADP-dependent alcohol dehydrogenase 6 1.1.1.2 0.664
1hsz NADAlcohol dehydrogenase 1B 1.1.1.1 0.663
5bsf NADPyrroline-5-carboxylate reductase / 0.663
2dt5 NADRedox-sensing transcriptional repressor Rex / 0.662
1sow NADL-lactate dehydrogenase 1.1.1.27 0.661
4bv9 NDPKetimine reductase mu-crystallin 1.5.1.25 0.661
2dbz NAPGlyoxylate reductase 1.1.1.26 0.660
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.660
3iup NDPPossible NADH oxidoreductase / 0.660
2fn7 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.659
1m75 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.658
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.658
4weq NAPNAD-dependent dehydrogenase / 0.658
1b8v NADMalate dehydrogenase / 0.656
3cin NADMyo-inositol-1-phosphate synthase-related protein / 0.656
4jnk NAIL-lactate dehydrogenase A chain 1.1.1.27 0.654
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.653
1pl6 NADSorbitol dehydrogenase 1.1.1.14 0.652
1t2d NADL-lactate dehydrogenase 1.1.1.27 0.651
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.650
3wbf NAPMeso-diaminopimelate D-dehydrogenase / 0.650