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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2wes FAD Tryptophan 5-halogenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2wes FADTryptophan 5-halogenase / 1.540
2aqj FADFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 1.127
2wet FADTryptophan 5-halogenase / 1.082
2apg FADFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.987
2ar8 FADFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.973
4z44 FADFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.932
4z43 FADFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.920
2jkc FADFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.915
2ard FDAFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.823
5hy5 FADTryptophan 6-halogenase / 0.768
2oa1 FADFlavin-dependent tryptophan halogenase RebH 1.14.19.9 0.727
1c0l FADD-amino-acid oxidase 1.4.3.3 0.717
5c3j FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.715
2qcu FADAerobic glycerol-3-phosphate dehydrogenase 1.1.5.3 0.702
5c2t FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.698
4yxd FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.696
4opt FDAConserved Archaeal protein / 0.695
1kqb FMNOxygen-insensitive NAD(P)H nitroreductase / 0.691
3ae4 FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.688
3ab1 FADFerredoxin--NADP reductase 1.18.1.2 0.686
4u8i FDAUDP-galactopyranose mutase / 0.686
3bi2 FADPolyamine oxidase FMS1 / 0.685
4opu FDAConserved Archaeal protein / 0.685
4u8n FDAUDP-galactopyranose mutase / 0.685
3ukf FDAUDP-galactopyranose mutase / 0.684
4j31 FADKynurenine 3-monooxygenase / 0.684
3nix FADFlavoprotein/dehydrogenase / 0.683
3all FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.682
1c0k FADD-amino-acid oxidase 1.4.3.3 0.681
2r0c FADPutative FAD-monooxygenase / 0.681
4wqm FADToluene-4-monooxygenase electron transfer component 1.18.1.3 0.681
4opl FDAConserved Archaeal protein / 0.680
2oal FADFlavin-dependent tryptophan halogenase RebH 1.14.19.9 0.678
4k5r FADOxygenase / 0.678
3gdp FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.677
1gaw FADFerredoxin / 0.676
2qa1 FADPgaE / 0.676
1lpf FADDihydrolipoyl dehydrogenase 1.8.1.4 0.674
3f8p NADNADH oxidase/thioredoxin reductase / 0.674
4j36 FADKynurenine 3-monooxygenase / 0.674
4u2l SFDCholesterol oxidase 1.1.3.6 0.674
1ib0 FADNADH-cytochrome b5 reductase 3 1.6.2.2 0.673
1kif FADD-amino-acid oxidase 1.4.3.3 0.673
2du8 FADD-amino-acid oxidase 1.4.3.3 0.673
4ynt FDAGlucose oxidase, putative / 0.673
1fnb FADFerredoxin--NADP reductase, chloroplastic 1.18.1.2 0.672
2gv8 FADThiol-specific monooxygenase 1.14.13 0.672
4u8l FDAUDP-galactopyranose mutase / 0.672
5j3w FMNSensory box protein / 0.672
2wp5 FADTrypanothione reductase / 0.671
4qi5 FADCellobiose dehydrogenase / 0.671
1icu FMNOxygen-insensitive NAD(P)H nitroreductase / 0.670
1qg0 FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic 1.18.1.2 0.670
2gmh FADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial 1.5.5.1 0.669
1icv FMNOxygen-insensitive NAD(P)H nitroreductase / 0.668
3qfc FADNADPH--cytochrome P450 reductase / 0.668
3uov FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.668
4qi4 FADCellobiose dehydrogenase / 0.668
4u8o FDAUDP-galactopyranose mutase / 0.668
4u2t FADCholesterol oxidase 1.1.3.6 0.667
4bk3 FADProbable salicylate monooxygenase / 0.666
1f8r FADL-amino-acid oxidase 1.4.3.2 0.665
1q1w FADPutidaredoxin reductase 1.18.1.5 0.663
2ywl FADThioredoxin reductase related protein / 0.663
3qfr FADNADPH--cytochrome P450 reductase / 0.663
4p2l FADSulfhydryl oxidase 1 1.8.3.2 0.663
2isk FNR5,6-dimethylbenzimidazole synthase 1.13.11.79 0.662
3axb FADPutative oxidoreductase / 0.662
4i58 FADCyclohexylamine Oxidase / 0.662
4udq FAD5-(hydroxymethyl)furfural oxidase / 0.662
3oz2 FADDigeranylgeranylglycerophospholipid reductase / 0.661
3qe2 FADNADPH--cytochrome P450 reductase / 0.661
4cy8 FDA2-hydroxybiphenyl-3-monooxygenase / 0.661
2rgh FADAlpha-Glycerophosphate Oxidase / 0.659
3cnd FADPolyamine oxidase FMS1 / 0.659
4eo3 FMNBacterioferritin comigratory protein/NADH dehydrogenase / 0.659
3f8r NAPNADH oxidase/thioredoxin reductase / 0.658
3utg FDAUDP-galactopyranose mutase / 0.657
4jn9 FADDepH / 0.657
1ger FADGlutathione reductase 1.8.1.7 0.656
1y56 ATPUncharacterized protein / 0.656
4bk2 FADProbable salicylate monooxygenase / 0.656
1geu FADGlutathione reductase 1.8.1.7 0.655
2eq8 FADDihydrolipoyl dehydrogenase / 0.655
5eow FAD6-hydroxynicotinate 3-monooxygenase 1.14.13.114 0.655
1rsg FADPolyamine oxidase FMS1 / 0.654
4jq9 FADDihydrolipoyl dehydrogenase / 0.654
4ytn FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.654
5g3s FDAFlavin-dependent L-tryptophan oxidase VioA / 0.654
2z1q FADAcyl-CoA dehydrogenase / 0.653
4jdr FADDihydrolipoyl dehydrogenase 1.8.1.4 0.653
1h7w FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.652
4udr FAD5-(hydroxymethyl)furfural oxidase / 0.652
1ju2 FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.651
1yqz FADCoenzyme A disulfide reductase / 0.651
3gyi FADCholesterol oxidase 1.1.3.6 0.651
3t2z FADSulfide-quinone reductase / 0.651
1gal FADGlucose oxidase 1.1.3.4 0.650
1ijh FADCholesterol oxidase 1.1.3.6 0.650
1oyc FMNNADPH dehydrogenase 1 1.6.99.1 0.650
2f5z FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.650
2gew FADCholesterol oxidase 1.1.3.6 0.650
2yr5 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.650
3nt6 FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.650