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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2rd6 78P Poly [ADP-ribose] polymerase 1 2.4.2.30

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2rd6 78PPoly [ADP-ribose] polymerase 1 2.4.2.30 0.869
3gn7 3GNPoly [ADP-ribose] polymerase 1 2.4.2.30 0.754
4tjy 3GNTankyrase-2 2.4.2.30 0.748
3l3l L3LPoly [ADP-ribose] polymerase 1 2.4.2.30 0.746
3c49 KU8Poly [ADP-ribose] polymerase 3 2.4.2.30 0.716
4hhz 15SPoly [ADP-ribose] polymerase 1 2.4.2.30 0.712
5ds3 09LPoly [ADP-ribose] polymerase 1 2.4.2.30 0.709
4r5w XAVPoly [ADP-ribose] polymerase 1 2.4.2.30 0.707
3c4h DRLPoly [ADP-ribose] polymerase 3 2.4.2.30 0.706
4gv7 MEWPoly [ADP-ribose] polymerase 1 2.4.2.30 0.703
1efy BZCPoly [ADP-ribose] polymerase 1 2.4.2.30 0.702
4avu LDRTankyrase-2 2.4.2.30 0.701
3l3m A92Poly [ADP-ribose] polymerase 1 2.4.2.30 0.700
4gv2 5MEPoly [ADP-ribose] polymerase 3 2.4.2.30 0.700
4avw G18Tankyrase-2 2.4.2.30 0.691
4bux F35Tankyrase-2 2.4.2.30 0.687
4buv 16ITankyrase-2 2.4.2.30 0.684
4bus 32FTankyrase-2 2.4.2.30 0.683
4bu9 08CTankyrase-2 2.4.2.30 0.682
4but 31FTankyrase-2 2.4.2.30 0.681
4tvj 09LPoly [ADP-ribose] polymerase 2 2.4.2.30 0.680
2rcw AAIPoly [ADP-ribose] polymerase 1 2.4.2.30 0.675
4msk 2C8Tankyrase-1 2.4.2.30 0.674
4pnm NU1Tankyrase-2 2.4.2.30 0.673
4buw F33Tankyrase-2 2.4.2.30 0.672
3u9y 09LTankyrase-2 2.4.2.30 0.668
4buf F36Tankyrase-2 2.4.2.30 0.668
4buu F38Tankyrase-2 2.4.2.30 0.665
4hlm 16STankyrase-2 2.4.2.30 0.664
4hlf 15ZTankyrase-2 2.4.2.30 0.663
4hlg 20BTankyrase-2 2.4.2.30 0.663
4l0s 1UZTankyrase-2 2.4.2.30 0.663
4l34 1VGTankyrase-2 2.4.2.30 0.663
4f1l 0RYPoly [ADP-ribose] polymerase 14 2.4.2.30 0.662
4f1q 0RZPoly [ADP-ribose] polymerase 14 2.4.2.30 0.662
4hki FLNTankyrase-2 2.4.2.30 0.662
4l09 1URTankyrase-2 2.4.2.30 0.662
4l0t 1V0Tankyrase-2 2.4.2.30 0.662
4l10 A63Tankyrase-2 2.4.2.30 0.662
4l33 F70Tankyrase-2 2.4.2.30 0.662
4l2k 1V8Tankyrase-2 2.4.2.30 0.661
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.660
4bud 29FTankyrase-2 2.4.2.30 0.660
4e5i 0N9Polymerase acidic protein / 0.660
4pnr G18Tankyrase-2 2.4.2.30 0.660
5dsy UHBPoly [ADP-ribose] polymerase 2 2.4.2.30 0.660
4tkg 09LTankyrase-2 2.4.2.30 0.657
3kr8 XAVTankyrase-2 2.4.2.30 0.656
4e5f 0N7Polymerase acidic protein / 0.656
2zit NADExotoxin A 2.4.2.36 0.654
4i9i 1DYTankyrase-1 2.4.2.30 0.654
5aku 29FTankyrase-2 2.4.2.30 0.654
3b8h NADExotoxin A 2.4.2.36 0.653