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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2o8h 227 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 3.1.4.17

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2o8h 227cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 3.1.4.17 1.021
3qpo PFRcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 3.1.4.17 0.782
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
1m3q ANGN-glycosylase/DNA lyase 3.2.2 0.744
1v2h GUNPurine nucleoside phosphorylase 2.4.2.1 0.744
4e5l DBHPolymerase acidic protein / 0.744
2ovy PFJcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 3.1.4.17 0.728
2ovv PFHcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 3.1.4.17 0.720
3uxv GUNNADPH-dependent 7-cyano-7-deazaguanine reductase / 0.688
3rzp PRFNADPH-dependent 7-cyano-7-deazaguanine reductase / 0.686
1ozq PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
1ulb GUNPurine nucleoside phosphorylase 2.4.2.1 0.660
2pwu GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
2z1x PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
3bld PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4e5f 0N7Polymerase acidic protein / 0.660
4gcx PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4hqv QEIQueuine tRNA-ribosyltransferase 2.4.2.29 0.660