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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2dbz NAP Glyoxylate reductase 1.1.1.26

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2dbz NAPGlyoxylate reductase 1.1.1.26 1.131
2dbq NAPGlyoxylate reductase 1.1.1.26 0.879
2dbr NAPGlyoxylate reductase 1.1.1.26 0.872
3baz NAPHydroxyphenylpyruvate reductase 1.1.1.237 0.870
2ekl NADD-3-phosphoglycerate dehydrogenase / 0.717
4e5k NADPhosphonate dehydrogenase 1.20.1.1 0.706
4oaq NDPR-specific carbonyl reductase / 0.697
4weq NAPNAD-dependent dehydrogenase / 0.694
4z0p NDPNAD-dependent dehydrogenase / 0.694
4j43 NADUncharacterized protein / 0.688
4j49 NADUncharacterized protein / 0.687
1agn NADAlcohol dehydrogenase class 4 mu/sigma chain 1.1.1.1 0.685
4wlu NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.684
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.681
1wwk NAD307aa long hypothetical phosphoglycerate dehydrogenase / 0.681
3oet NADErythronate-4-phosphate dehydrogenase / 0.681
4c4o NADSADH / 0.681
1hku NADC-terminal-binding protein 1 1.1.1 0.679
4l0q NADAlcohol dehydrogenase class-3 / 0.676
3kb6 NADD-lactate dehydrogenase / 0.675
4jk3 NADUncharacterized protein / 0.675
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.674
4e5m NAPPhosphonate dehydrogenase 1.20.1.1 0.674
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.673
3two NDPMannitol dehydrogenase / 0.673
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 0.672
4j49 NAIUncharacterized protein / 0.671
4j4b NAIUncharacterized protein / 0.668
1p0f NAPNADP-dependent alcohol dehydrogenase 1.1.1.2 0.667
2g76 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.667
3n7u NADFormate dehydrogenase, chloroplastic/mitochondrial / 0.667
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 0.665
2d2i NAPGlyceraldehyde-3-phosphate dehydrogenase / 0.665
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.665
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 0.664
4ejm NAPPutative zinc-binding dehydrogenase / 0.663
1hdz NADAlcohol dehydrogenase 1B 1.1.1.1 0.662
5dt9 NADErythronate-4-phosphate dehydrogenase / 0.662
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 0.661
1j0x NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.661
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 0.660
2xaa NADSecondary alcohol dehydrogenase / 0.660
5env NADAlcohol dehydrogenase 1 1.1.1.1 0.660
4nu5 NADPhosphonate dehydrogenase 1.20.1.1 0.658
4w6z 8IDAlcohol dehydrogenase 1 1.1.1.1 0.658
2ome NADC-terminal-binding protein 2 / 0.657
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 0.657
3kbo NDPGlyoxylate/hydroxypyruvate reductase A / 0.657
4lcj NADC-terminal-binding protein 2 / 0.657
1mp0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.656
2dc1 NADProbable L-aspartate dehydrogenase / 0.656
3wsw NADL-lactate dehydrogenase / 0.656
1teh NADAlcohol dehydrogenase class-3 1.1.1.1 0.655
2o4c NADErythronate-4-phosphate dehydrogenase / 0.655
3wbf NAPMeso-diaminopimelate D-dehydrogenase / 0.655
1ma0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.654
4gl4 NAIAlcohol dehydrogenase class-3 / 0.654
1j49 NADD-lactate dehydrogenase 1.1.1.28 0.653
5bqf NAPProbable hydroxyacid dehydrogenase protein / 0.653
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.652
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.652
1o8c NDPProbable acrylyl-CoA reductase AcuI 1.3.1.84 0.651
2eer NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.651
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.651
4jji NADAlcohol dehydrogenase class-3 / 0.651
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 0.651
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 0.651
5kj1 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.651
4tvb NADHomospermidine synthase 2.5.1.44 0.650
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 0.650
4xrg NADHomospermidine synthase 2.5.1.44 0.650