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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2d4e NAD 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831]

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2d4e NAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831] / 1.193
2ehu NAD1-pyrroline-5-carboxylate dehydrogenase / 0.936
2j5n NAD1-pyrroline-5-carboxylate dehydrogenase / 0.935
2eii NAD1-pyrroline-5-carboxylate dehydrogenase / 0.931
4i1w NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.926
1o9j NADAldehyde dehydrogenase, cytosolic 1 1.2.1.3 0.925
4oe2 NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.911
2j40 NAD1-pyrroline-5-carboxylate dehydrogenase / 0.907
2bhp NAD1-pyrroline-5-carboxylate dehydrogenase / 0.893
4i8p NADAminoaldehyde dehydrogenase 1 / 0.891
4pz2 NADAldehyde dehydrogenase 2-6 / 0.884
1t90 NADMalonate-semialdehyde dehydrogenase 1.2.1.27 0.880
3efv NADPutative succinate-semialdehyde dehydrogenase / 0.872
4gnz NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.871
4v37 NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.870
4i8q NADPutative betaine aldehyde dehyrogenase / 0.862
3b4w NADAldehyde dehydrogenase family protein / 0.861
2jg7 NADAntiquitin / 0.859
1uxr NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.858
2ehq NAP1-pyrroline-5-carboxylate dehydrogenase / 0.858
1o04 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.843
3rhj NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.842
3rhl NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.833
1uxt NADNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.825
4a0m NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.820
3haz NADBifunctional protein PutA / 0.807
2eit NAD1-pyrroline-5-carboxylate dehydrogenase / 0.802
2o2q NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.801
3rhq NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.781
3rhr NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.781
1uxn NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.780
2j6l NAIAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.776
3v9l NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.772
2euh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.758
1a4z NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.754
4pxl NADAldehyde dehydrogenase3 / 0.746
4pxn NADAldehyde dehydrogenase family 7 member B4 / 0.742
1uxv NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.741
1ky8 NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.740
3iwj NADAminoaldehyde dehydrogenase / 0.736
1uxp NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.729
3lv1 NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.727
1o00 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.726
3lns NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.726
1bpw NADBetaine aldehyde dehydrogenase 1.2.1.8 0.725
1o01 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.722
4go2 TAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.722
1nzz NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.718
2onp NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.716
4ihi NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.714
4wb9 NAIRetinal dehydrogenase 1 1.2.1.36 0.714
1bxs NADRetinal dehydrogenase 1 1.2.1.36 0.711
4x4l NAIRetinal dehydrogenase 1 1.2.1.36 0.711
4x2q NADRetinal dehydrogenase 2 1.2.1.36 0.709
4fqf NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.707
2id2 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.706
4f3x NADPutative aldehyde dehydrogenase / 0.704
1wnb NAIGamma-aminobutyraldehyde dehydrogenase 1.2.1.19 0.701
4i9b NADPutative betaine aldehyde dehyrogenase / 0.701
1nzw NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.696
4nmk NAPAldehyde dehydrogenase / 0.692
1o02 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.691
3n82 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.690
2onm NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.688
3rhd NAPLactaldehyde dehydrogenase 1.2.1.22 0.685
4c3s NADAldehyde Dehydrogenase / 0.685
4jdc NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.685
1cw3 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.683
4nmj NAPAldehyde dehydrogenase / 0.682
2y5d NAP3,4-dehydroadipyl-CoA semialdehyde dehydrogenase / 0.677
4fr8 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.676
3rho NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.670
4pt0 NADAldehyde dehydrogenase / 0.670
2o2r NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.666
4zz7 NADMethylmalonate-semialdehyde dehydrogenase / 0.661
1nzx NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.655
3n83 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.654
3ju8 NADN-succinylglutamate 5-semialdehyde dehydrogenase 1.2.1.71 0.650