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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1zao ATP RIO-type serine/threonine-protein kinase Rio2 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1zao ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 1.016
1tqp ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.780
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.756
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.749
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.739
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.737
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.736
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.732
5l8k ADPAurora kinase A 2.7.11.1 0.729
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.726
3c4z ADPRhodopsin kinase / 0.725
4n57 ADPAPH(2'')-Id / 0.720
4c3r ACPAurora kinase A 2.7.11.1 0.718
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.716
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.715
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.713
2pup ADPMethylthioribose kinase 2.7.1.100 0.712
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.712
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.711
3wnz ADPAlanine--anticapsin ligase / 0.708
4ffl ADPUncharacterized protein / 0.708
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.706
2pui ADPMethylthioribose kinase 2.7.1.100 0.705
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.703
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.702
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.701
3dnt ATPSerine/threonine-protein kinase toxin HipA / 0.700
4ceg ADPAurora kinase A 2.7.11.1 0.700
4eom ATPCyclin-dependent kinase 2 2.7.11.22 0.698
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.696
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.694
3fzp AGSProtein-tyrosine kinase 2-beta 2.7.10.2 0.694
3tpt ADPSerine/threonine-protein kinase toxin HipA / 0.691
4qny ANPMitogen activated protein kinase, putative / 0.690
4dee ADPAurora kinase A 2.7.11.1 0.689
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.688
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.687
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.686
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.686
4xlv ACPInsulin receptor 2.7.10.1 0.686
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.685
4ffm ADPUncharacterized protein / 0.685
4s33 ANPMitogen-activated protein kinase 1 2.7.11.24 0.685
1mq4 ADPAurora kinase A 2.7.11.1 0.682
2pzp ACPFibroblast growth factor receptor 2 / 0.681
3qc9 ADPRhodopsin kinase / 0.681
3t99 ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.681
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.680
3att ATPPutative aminoglycoside phosphotransferase 2.7.1 0.679
5ce3 ADPProtein kinase YopO / 0.679
5iqi GNPBifunctional AAC/APH 2.3.1 0.679
4utd ACPAurora kinase A 2.7.11.1 0.678
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.678
4c5c ATPD-alanine--D-alanine ligase B 6.3.2.4 0.677
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.676
3q5i ANPProtein kinase, putative / 0.675
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.674
3nie ANPMitogen-activated protein kinase / 0.674
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.674
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.673
2dwb ANPAurora kinase A 2.7.11.1 0.673
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.673
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.672
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.672
5dr2 ATPAurora kinase A 2.7.11.1 0.672
3c50 ADPRhodopsin kinase / 0.671
4lv8 ADPRhoptry protein 5 C / 0.671
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.670
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.670
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.670
3c4w ATPRhodopsin kinase / 0.670
5dos ATPAurora kinase A 2.7.11.1 0.670
1q99 ANPSerine/threonine-protein kinase SKY1 2.7.11.1 0.669
4wh2 ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.667
3ori AGSSerine/threonine protein kinase / 0.666
4o1p ANPRibonuclease L / 0.666
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.666
5dt3 ATPAurora kinase A 2.7.11.1 0.666
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.665
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.665
2io8 ADPBifunctional glutathionylspermidine synthetase/amidase / 0.665
2pz5 ACPFibroblast growth factor receptor 2 / 0.665
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.664
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.664
3t9f ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.664
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.664
5iqe GNPBifunctional AAC/APH 2.3.1 0.664
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.663
1w2d ADPInositol-trisphosphate 3-kinase A 2.7.1.127 0.663
5iqa GNPBifunctional AAC/APH 2.3.1 0.663
4o4d ATPKinase / 0.662
1t36 ADPCarbamoyl-phosphate synthase large chain / 0.661
2qo9 ANPEphrin type-A receptor 3 2.7.10.1 0.661
1ol6 ATPAurora kinase A 2.7.11.1 0.660
2ijm ATPFocal adhesion kinase 1 2.7.10.2 0.660
3t7o UPGGlycogenin-1 2.4.1.186 0.660
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.660
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.660
4y12 AGSSerine/threonine-protein kinase PknG 2.7.11.1 0.660
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.659
1mp8 ADPFocal adhesion kinase 1 2.7.10.2 0.658
2qoq ANPEphrin type-A receptor 3 2.7.10.1 0.658
3tdw GDPGentamicin resistance protein / 0.658
5dt4 ATPAurora kinase A 2.7.11.1 0.658
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.657
4ysj ADPCalmodulin-like domain protein kinase / 0.657
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.656
2wqe ADPAurora kinase A 2.7.11.1 0.655
3vx4 ATPPutative ABC transporter, ATP-binding protein ComA / 0.655
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.655
1pkg ADPMast/stem cell growth factor receptor Kit 2.7.10.1 0.654
2pun ACPMethylthioribose kinase 2.7.1.100 0.654
2w02 ATPAcsD / 0.654
3g8d ADPBiotin carboxylase 6.3.4.14 0.654
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.654
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.654
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.654
2pyw ADPMethylthioribose kinase 2.7.1.100 0.653
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.653
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.652
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.652
2acx ANPG protein-coupled receptor kinase 6 2.7.11.16 0.651
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.651
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.650
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.650