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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1z2p ACP Inositol-tetrakisphosphate 1-kinase 2.7.1.134

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1z2p ACPInositol-tetrakisphosphate 1-kinase 2.7.1.134 1.143
1z2n ADPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.908
4nzo ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.852
3t9a ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.848
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.825
2io7 ANPBifunctional glutathionylspermidine synthetase/amidase / 0.800
4q4c ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.794
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.789
3t9d ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.787
3wnz ADPAlanine--anticapsin ligase / 0.785
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.784
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.782
3t9f ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.781
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.780
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.779
4ffm ADPUncharacterized protein / 0.779
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.778
4ffr ATPUncharacterized protein / 0.776
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.769
3q1k ADPD-alanine--D-alanine ligase A 6.3.2.4 0.768
3wo0 ADPAlanine--anticapsin ligase / 0.766
3vpb ADPGlutamate--LysW ligase ArgX 6.3.2 0.764
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.761
2io9 ADPBifunctional glutathionylspermidine synthetase/amidase / 0.760
2io8 ADPBifunctional glutathionylspermidine synthetase/amidase / 0.753
2p0a ANPSynapsin-3 / 0.752
1m0w ANPGlutathione synthetase 6.3.2.3 0.751
3i12 ADPD-alanine--D-alanine ligase A 6.3.2.4 0.751
3dnt ATPSerine/threonine-protein kinase toxin HipA / 0.750
3vpc ADPGlutamate--LysW ligase ArgX 6.3.2 0.750
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.749
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.748
3lla ACPMyosin heavy chain kinase A 2.7.11.7 0.747
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.743
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.742
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.741
2ioa ADPBifunctional glutathionylspermidine synthetase/amidase / 0.738
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.738
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.735
2zdg ADPD-alanine--D-alanine ligase / 0.733
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.732
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.732
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.732
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.731
4c5c ATPD-alanine--D-alanine ligase B 6.3.2.4 0.729
3g8d ADPBiotin carboxylase 6.3.4.14 0.728
3tw6 ADPPyruvate carboxylase / 0.728
5c1p ADPD-alanine--D-alanine ligase / 0.728
2r7n ADP5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase / 0.727
3k5h ATPPhosphoribosyl-aminoimidazole carboxylase / 0.727
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.723
1px2 ATPSynapsin-1 / 0.722
2pyw ADPMethylthioribose kinase 2.7.1.100 0.720
3rv4 ADPBiotin carboxylase 6.3.4.14 0.720
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.719
4ffl ADPUncharacterized protein / 0.718
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.716
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.714
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.714
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.713
4wh2 ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.713
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.708
5ce3 ADPProtein kinase YopO / 0.707
5e9e ANPMyosin heavy chain kinase A 2.7.11.7 0.707
4dee ADPAurora kinase A 2.7.11.1 0.706
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.704
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.704
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.704
4zs4 ATPMyosin heavy chain kinase A 2.7.11.7 0.704
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.703
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.702
4mam A12N5-carboxyaminoimidazole ribonucleotide synthase / 0.701
3r5f ATPD-alanine--D-alanine ligase / 0.700
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.699
4qny ANPMitogen activated protein kinase, putative / 0.699
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.695
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.693
2r86 ATP5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase / 0.693
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.693
4iwy ADPRibosomal protein S6--L-glutamate ligase / 0.693
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.692
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.692
2pui ADPMethylthioribose kinase 2.7.1.100 0.690
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.690
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.689
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.689
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.688
4zme ADNMyosin heavy chain kinase A 2.7.11.7 0.688
5iqb GNPBifunctional AAC/APH 2.3.1 0.688
4zgn ATPCell division cycle protein 123 / 0.687
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.686
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.684
3eth ATPN5-carboxyaminoimidazole ribonucleotide synthase / 0.682
3t54 ATPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.681
4iwx ADPRibosomal protein S6--L-glutamate ligase / 0.681
5jqw ADPN5-carboxyaminoimidazole ribonucleotide synthase / 0.681
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.680
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.680
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.680
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.679
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.679
5iqh GNPBifunctional AAC/APH 2.3.1 0.679
2xcl ANPPhosphoribosylamine--glycine ligase / 0.678
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.678
4fu0 ADPD-alanine--D-alanine ligase / 0.678
1ia9 ANPTransient receptor potential cation channel subfamily M member 7 2.7.11.1 0.677
3cvu FADRE11660p / 0.677
3cvy FADRE11660p / 0.677
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.676
2wq7 FADRE11660p / 0.675
4btj ATPTau-tubulin kinase 1 2.7.11.1 0.675
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.675
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.674
1iah ADPTransient receptor potential cation channel subfamily M member 7 2.7.11.1 0.673
4zol ACPTubulin tyrosine ligase / 0.673
3wo1 ADPAlanine--anticapsin ligase / 0.672
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.672
1cm8 ANPMitogen-activated protein kinase 12 / 0.671
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.671
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.671
1mqb ANPEphrin type-A receptor 2 2.7.10.1 0.670
2j0l ANPFocal adhesion kinase 1 2.7.10.2 0.670
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.670
4ork GDPBifunctional AAC/APH 2.3.1 0.669
4gyi ADPUncharacterized protein / 0.667
3lmh ADPMyosin heavy chain kinase A 2.7.11.7 0.665
1aux AGSSynapsin-1 / 0.662
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.662
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.661
3att ATPPutative aminoglycoside phosphotransferase 2.7.1 0.661
3pdt ADPMyosin heavy chain kinase A 2.7.11.7 0.661
1ol6 ATPAurora kinase A 2.7.11.1 0.659
3dqw AGSProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.659
3tdw GDPGentamicin resistance protein / 0.659
3tpt ADPSerine/threonine-protein kinase toxin HipA / 0.659
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.658
3tdv GDPGentamicin resistance protein / 0.658
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.657
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.657
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.657
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.656
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.656
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.655
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.655
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.654
2wq6 FADRE11660p / 0.654
2hgs ADPGlutathione synthetase 6.3.2.3 0.650
5iqa GNPBifunctional AAC/APH 2.3.1 0.650