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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1yjq NAP 2-dehydropantoate 2-reductase 1.1.1.169

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1yjq NAP2-dehydropantoate 2-reductase 1.1.1.169 1.179
3hwr NDP2-dehydropantoate 2-reductase / 0.841
1yon A2R2-dehydropantoate 2-reductase 1.1.1.169 0.756
5hws NAP2-dehydropantoate 2-reductase / 0.728
2cvz NDP3-hydroxyisobutyrate dehydrogenase / 0.722
1cf2 NAPGlyceraldehyde-3-phosphate dehydrogenase / 0.709
4y1b NAPAntE / 0.709
1f0y NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.705
3q3c NADNAD-dependent L-serine dehydrogenase / 0.702
3keo NADRedox-sensing transcriptional repressor Rex / 0.701
3f3s NADLambda-crystallin homolog / 0.698
3tri NAPPyrroline-5-carboxylate reductase / 0.698
1il0 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.697
1wp4 NDP3-hydroxyisobutyrate dehydrogenase / 0.697
2rcy NAPPyrroline-5-carboxylate reductase / 0.697
3a14 NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase / 0.696
5a04 NDPGlucose-fructose oxidoreductase / 0.695
5a02 NAPGlucose-fructose oxidoreductase / 0.694
4xr9 NADCalS8 / 0.693
2ixb NADAlpha-N-acetylgalactosaminidase 3.2.1.49 0.692
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.692
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.692
5ijz NAPNADP-specific glutamate dehydrogenase 1.4.1.4 0.692
2ixa NADAlpha-N-acetylgalactosaminidase 3.2.1.49 0.691
2jd1 NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase / 0.690
3mvq NDPGlutamate dehydrogenase 1, mitochondrial 1.4.1.3 0.690
2voj NADAlanine dehydrogenase 1.4.1.1 0.689
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.687
3b1j NADGlyceraldehyde-3-phosphate dehydrogenase / 0.686
3wfj NAD2-dehydropantoate 2-reductase / 0.686
5aq1 NDPGlucose-6-phosphate 1-dehydrogenase / 0.685
1m76 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.684
2q3e NAIUDP-glucose 6-dehydrogenase 1.1.1.22 0.684
2vhw NAIAlanine dehydrogenase 1.4.1.1 0.684
3pef NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.679
3au8 NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic 1.1.1.267 0.678
5a06 NDPGlucose-fructose oxidoreductase / 0.677
1vi2 NADQuinate/shikimate dehydrogenase / 0.675
5a05 NDPGlucose-fructose oxidoreductase / 0.675
5ein NAP[LysW]-L-2-aminoadipate 6-phosphate reductase / 0.674
4wji NAPPutative cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase / 0.673
5c7o NADGlyceraldehyde-3-phosphate dehydrogenase, testis-specific 1.2.1.12 0.673
5dul NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase / 0.673
1vsv NADGlyceraldehyde-3-phosphate dehydrogenase / 0.672
3keq NADRedox-sensing transcriptional repressor Rex / 0.670
3o9z NADLipopolysaccaride biosynthesis protein wbpB / 0.670
3v1y NADGlyceraldehyde-3-phosphate dehydrogenase 1, cytosolic 1.2.1.12 0.670
3ras NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase / 0.669
4hfm NAP2-alkenal reductase (NADP(+)-dependent) / 0.669
3nt2 NADInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.668
3anl NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase 1.1.1.267 0.667
3ikt NADRedox-sensing transcriptional repressor Rex / 0.667
3pdu NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.667
5bsg NAPPyrroline-5-carboxylate reductase / 0.667
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.665
1lj8 NADMannitol dehydrogenase / 0.665
1qr6 NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.665
4y0k NAPAntE / 0.665
2yyy NAPGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.59 0.664
4ebf NADPhosphonate dehydrogenase 1.20.1.1 0.664
1h6a NDPGlucose--fructose oxidoreductase 1.1.99.28 0.663
2i9p NAD3-hydroxyisobutyrate dehydrogenase, mitochondrial 1.1.1.31 0.663
4tqg NDPPutative dTDP-d-glucose 4 6-dehydratase / 0.662
4xgi NADGlutamate dehydrogenase / 0.662
4om8 NAD3-hydroxybutyryl-coA dehydrogenase / 0.660
5bt9 NAP3-oxoacyl-(Acyl-carrier-protein) reductase / 0.660
3ids NADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal 1.2.1.12 0.658
3oa2 NADUDP-N-acetyl-2-amino-2-deoxy-D-glucuronate oxidase / 0.658
4dpl NAPMalonyl-CoA reductase 1.2.1.75 0.658
1hdg NADGlyceraldehyde-3-phosphate dehydrogenase / 0.657
2jcv NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase / 0.657
1u8f NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.656
2g76 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.656
3had NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.656
3w6u NAP6-phosphogluconate dehydrogenase, NAD-binding protein / 0.656
4lsm NADGlyceraldehyde-3-phosphate dehydrogenase / 0.656
4p8r NADGlyceraldehyde-3-phosphate dehydrogenase / 0.656
1h6b NDPGlucose--fructose oxidoreductase 1.1.99.28 0.655
1pjc NADAlanine dehydrogenase / 0.654
1dss NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.653
1h6d NDPGlucose--fructose oxidoreductase 1.1.99.28 0.653
3tnl NADShikimate dehydrogenase (NADP(+)) / 0.653
4o59 NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.653
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.652
3cif NADGlyceraldehyde-3-phosphate dehydrogenase / 0.652
1h6c NDPGlucose--fructose oxidoreductase 1.1.99.28 0.651
1m75 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.651
4k9d NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.651