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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1ydr IQP cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1ydr IQPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.903
2c1a I5ScAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.776
2gnl H52cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.774
3vqh IQBcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.763
2f7e 2EAcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.762
2f2u M77Rho-associated protein kinase 2 2.7.11.1 0.749
1q8u H52cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.747
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
1m3q ANGN-glycosylase/DNA lyase 3.2.2 0.744
1v2h GUNPurine nucleoside phosphorylase 2.4.2.1 0.744
2puc GUNHTH-type transcriptional repressor PurR / 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4e5l DBHPolymerase acidic protein / 0.744
4ek9 EP4Histone-lysine N-methyltransferase, H3 lysine-79 specific 2.1.1.43 0.744
2c1b CQPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.738
2gni M77cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.726
2gnh H52cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.709
3oog YTPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.707
2hxl 422Serine/threonine-protein kinase Chk1 2.7.11.1 0.703
1ydt IQBcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.701
3tku M77Serine/threonine-protein kinase MRCK beta 2.7.11.1 0.695
1q8w M77cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.686
3l9n L9NcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.683
3py0 SU9Cyclin-dependent kinase 2 2.7.11.22 0.669
3tkh 07SSerine/threonine-protein kinase Chk1 2.7.11.1 0.664
2nry STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.663
2pe2 4643-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.663
1rek B8LcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.662
3qcx 3Q23-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.662
3tki S25Serine/threonine-protein kinase Chk1 2.7.11.1 0.662
1p2a 5BNCyclin-dependent kinase 2 2.7.11.22 0.661
2uzw SS4cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.661
3ezv EZVCyclin-dependent kinase 2 2.7.11.22 0.661
1ozq PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
1p0e PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
1ulb GUNPurine nucleoside phosphorylase 2.4.2.1 0.660
2pot GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
2pwu GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
2z1x PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
3bld PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
3zly YSODual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.660
4h7z GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4hqv QEIQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4hvx QEIQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
1gih 1PUCyclin-dependent kinase 2 2.7.11.22 0.659
2pe1 5173-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.659
3l9l L9LcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.658
4c34 STUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.657
2oh0 2PYcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.655
1svh I08cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.654
2hxq 373Serine/threonine-protein kinase Chk1 2.7.11.1 0.654
2hy0 306Serine/threonine-protein kinase Chk1 2.7.11.1 0.654
3f69 XDRSerine/threonine-protein kinase PknB 2.7.11.1 0.654
3fmm XI2Mitogen-activated protein kinase 14 / 0.654
3qcs 3Q13-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.654
1nvr STUSerine/threonine-protein kinase Chk1 2.7.11.1 0.653
1p4f DRGDeath-associated protein kinase 1 2.7.11.1 0.653
1yhs STUSerine/threonine-protein kinase pim-1 2.7.11.1 0.653
2c3l IDZSerine/threonine-protein kinase Chk1 2.7.11.1 0.653
3qcy 3Q33-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.653
2gdo 12CSerine/threonine-protein kinase Chk1 2.7.11.1 0.651
1fel FENRetinol-binding protein 4 / 0.650