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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1q8y ADP Serine/threonine-protein kinase SKY1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 1.003
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.844
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.844
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.831
5dr2 ATPAurora kinase A 2.7.11.1 0.820
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.805
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.800
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.800
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.798
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.798
4ceg ADPAurora kinase A 2.7.11.1 0.797
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.795
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.794
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.789
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.788
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.786
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.784
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.784
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.784
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.783
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.779
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.776
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.772
5dt3 ATPAurora kinase A 2.7.11.1 0.771
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.770
4dee ADPAurora kinase A 2.7.11.1 0.770
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.769
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.766
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.766
2pyw ADPMethylthioribose kinase 2.7.1.100 0.765
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.765
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.764
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.763
4jr7 GNPCasein kinase II subunit alpha 2.7.11.1 0.762
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.761
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.759
5dn3 ATPAurora kinase A 2.7.11.1 0.759
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.755
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.752
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.751
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.750
5drd ATPAurora kinase A 2.7.11.1 0.750
2pml ANPUncharacterized protein / 0.749
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.747
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.745
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.745
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.744
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.743
5dos ATPAurora kinase A 2.7.11.1 0.743
1mq4 ADPAurora kinase A 2.7.11.1 0.742
3g8c ADPBiotin carboxylase 6.3.4.14 0.742
4qny ANPMitogen activated protein kinase, putative / 0.741
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.739
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.739
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.739
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.737
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.736
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.736
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.734
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.732
4gyi ADPUncharacterized protein / 0.731
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.731
5dmz ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.731
2pz5 ACPFibroblast growth factor receptor 2 / 0.730
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.730
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.730
4ysj ADPCalmodulin-like domain protein kinase / 0.730
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.729
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.728
4axf ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.725
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.724
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.724
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.724
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.723
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.722
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.721
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.720
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.720
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.719
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.718
5eg3 ACPFibroblast growth factor receptor 2 / 0.718
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.717
4riy ADPEpidermal growth factor receptor 2.7.10.1 0.715
5ce3 ADPProtein kinase YopO / 0.714
5dt4 ATPAurora kinase A 2.7.11.1 0.714
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.712
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.712
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.711
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.710
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.710
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.709
2j9g ADPBiotin carboxylase 6.3.4.14 0.709
2olc ADPMethylthioribose kinase 2.7.1.100 0.709
2py3 ACPFibroblast growth factor receptor 2 / 0.709
4ork GDPBifunctional AAC/APH 2.3.1 0.708
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.707
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.707
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.706
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.705
1cm8 ANPMitogen-activated protein kinase 12 / 0.703
4btj ATPTau-tubulin kinase 1 2.7.11.1 0.703
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.703
3ori AGSSerine/threonine protein kinase / 0.702
2zdg ADPD-alanine--D-alanine ligase / 0.701
3c4z ADPRhodopsin kinase / 0.701
3ort AGSSerine/threonine protein kinase / 0.701
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.700
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.700
2pun ACPMethylthioribose kinase 2.7.1.100 0.699
4pds ANPSerine/threonine-protein kinase RAD53 2.7.12.1 0.699
3c50 ADPRhodopsin kinase / 0.698
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.696
4lv8 ADPRhoptry protein 5 C / 0.696
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.695
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.694
2xs0 ANPMitogen-activated protein kinase 8 2.7.11.24 0.693
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.690
4axd ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.690
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.690
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.689
1dv2 ATPBiotin carboxylase 6.3.4.14 0.688
1ol7 ADPAurora kinase A 2.7.11.1 0.688
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.688
3nie ANPMitogen-activated protein kinase / 0.688
1q97 ATPSerine/threonine-protein kinase SKY1 2.7.11.1 0.686
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.686
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.686
1ol6 ATPAurora kinase A 2.7.11.1 0.685
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.685
4bn1 ADPAurora kinase A 2.7.11.1 0.684
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.684
3mia ANPCyclin-dependent kinase 9 2.7.11.22 0.683
4s33 ANPMitogen-activated protein kinase 1 2.7.11.24 0.683
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.683
3qc9 ADPRhodopsin kinase / 0.682
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.680
2pzp ACPFibroblast growth factor receptor 2 / 0.679
3g6w GTPUracil phosphoribosyltransferase 2.4.2.9 0.679
5iqh GNPBifunctional AAC/APH 2.3.1 0.678
2pup ADPMethylthioribose kinase 2.7.1.100 0.676
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.676
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.674
4utd ACPAurora kinase A 2.7.11.1 0.674
1pkg ADPMast/stem cell growth factor receptor Kit 2.7.10.1 0.673
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.673
4wh2 ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.673
1csn ATPCasein kinase I homolog 1 2.7.11.1 0.672
4o1p ANPRibonuclease L / 0.672
5iqf GDPBifunctional AAC/APH 2.3.1 0.672
2dwb ANPAurora kinase A 2.7.11.1 0.671
3g51 ANPRibosomal protein S6 kinase alpha-3 2.7.11.1 0.671
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.671
4fl2 ANPTyrosine-protein kinase SYK 2.7.10.2 0.671
2vqd AP2Biotin carboxylase 6.3.4.14 0.669
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.669
3oro AGSSerine/threonine protein kinase / 0.669
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.668
1w2d ADPInositol-trisphosphate 3-kinase A 2.7.1.127 0.667
4xlv ACPInsulin receptor 2.7.10.1 0.666
4ocp ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.665
3vpb ADPGlutamate--LysW ligase ArgX 6.3.2 0.664
4ffr ATPUncharacterized protein / 0.664
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.663
4o0u ADNAurora kinase A 2.7.11.1 0.663
1gy3 ATPCyclin-dependent kinase 2 2.7.11.22 0.662
3tdw GDPGentamicin resistance protein / 0.662
4c5c ATPD-alanine--D-alanine ligase B 6.3.2.4 0.662
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.662
4ic7 ANPMitogen-activated protein kinase 7 2.7.11.24 0.662
2pul ACPMethylthioribose kinase 2.7.1.100 0.661
2wqe ADPAurora kinase A 2.7.11.1 0.661
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.660
2pui ADPMethylthioribose kinase 2.7.1.100 0.660
3vjn ANPEpidermal growth factor receptor 2.7.10.1 0.660
3t54 ATPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.659
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.659
5byl GCPBifunctional AAC/APH 2.3.1 0.659
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.658
3bu5 ATPInsulin receptor 2.7.10.1 0.658
3udz ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.657
3akl ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.656
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.656
3t8o ATPRhodopsin kinase / 0.656
4aw0 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.656
5iqg GDPBifunctional AAC/APH 2.3.1 0.656
2fsn ADPArchaeal actin homolog / 0.655
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.654
3orm AGSSerine/threonine protein kinase / 0.654
5dnr ATPAurora kinase A 2.7.11.1 0.654
2vnw M01cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.653
3wow ANPCasein kinase II subunit alpha 2.7.11.1 0.653
4o4d ATPKinase / 0.653
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.652
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.650