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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1pu9 COA HAT A1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1pu9 COAHAT A1 / 1.260
1qsn COAHAT A1 / 1.027
1pua COAHAT A1 / 0.895
1qsr ACOHAT A1 / 0.893
2ozu ACOHistone acetyltransferase KAT6A / 0.842
1kuv CA5Serotonin N-acetyltransferase / 0.833
1z4r ACOHistone acetyltransferase KAT2A 2.3.1.48 0.831
1kux CA3Serotonin N-acetyltransferase / 0.830
1cm0 COAHistone acetyltransferase KAT2B 2.3.1.48 0.818
1l0c COTSerotonin N-acetyltransferase / 0.799
1mjb ACOHistone acetyltransferase ESA1 / 0.798
1m1d LYXHAT A1 / 0.797
1fy7 COAHistone acetyltransferase ESA1 / 0.796
1mja COAHistone acetyltransferase ESA1 / 0.794
5kf9 COAPredicted acetyltransferase / 0.782
5h86 BCOHistone acetyltransferase KAT2A 2.3.1.48 0.780
5kgp ACOPredicted acetyltransferase / 0.778
5kf9 ACOPredicted acetyltransferase / 0.777
5kgj ACOPredicted acetyltransferase / 0.776
1cjw COTSerotonin N-acetyltransferase / 0.775
4r3k COAN-alpha-acetyltransferase 2.3.1 0.775
2x7b COAN-alpha-acetyltransferase 2.3.1 0.772
1ib1 COTSerotonin N-acetyltransferase / 0.770
2r8v ACOAmino-acid acetyltransferase / 0.761
2vzz SCAPutative succinyl-CoA transferase Rv0802c 2.8.3 0.761
2y0m ACOHistone acetyltransferase KAT8 / 0.760
4u9y COAAlpha-tubulin N-acetyltransferase 1 / 0.760
5kf8 ACOPredicted acetyltransferase / 0.758
5h84 1VUHistone acetyltransferase KAT2A 2.3.1.48 0.755
4lx9 ACON-alpha-acetyltransferase 2.3.1 0.751
2q4v ACODiamine acetyltransferase 2 2.3.1.57 0.749
5kf1 ACOPredicted acetyltransferase / 0.745
2a4n COAAac(6')-Ii protein / 0.738
2prb COAAminoglycoside 6-N-acetyltransferase type Ib11 / 0.737
3mgd ACOPredicted acetyltransferase / 0.732
1tiq COASpermidine/spermine N(1)-acetyltransferase / 0.731
4u9v ACON-alpha-acetyltransferase 40 2.3.1 0.731
2fiw ACOGCN5-related N-acetyltransferase:Aminotransferase, class-II / 0.730
1i12 ACOGlucosamine 6-phosphate N-acetyltransferase / 0.728
1kuy COTSerotonin N-acetyltransferase / 0.728
1wwz ACOUncharacterized protein / 0.728
2vez ACOGlucosamine 6-phosphate acetyltransferase, putative / 0.722
4hkf ACOAlpha-tubulin N-acetyltransferase 1 / 0.722
1b87 ACOAac(6')-Ii protein / 0.721
2cns ACORibosomal-protein-alanine acetyltransferase / 0.721
2fxf ACODiamine acetyltransferase 1 / 0.721
4xpd ACON-terminal acetyltransferase A complex subunit NAT5 2.3.1 0.721
2b58 COADiamine acetyltransferase 1 / 0.719
2giv ACOHistone acetyltransferase KAT8 / 0.715
5kf1 COAPredicted acetyltransferase / 0.715
1p0h COAMycothiol acetyltransferase 2.3.1.189 0.713
1v0c ACOAAC(6')-Ib / 0.713
2vxk COAGlucosamine 6-phosphate acetyltransferase, putative / 0.710
4ag7 COAGlucosamine 6-phosphate N-acetyltransferase / 0.710
2rc4 ACOHistone acetyltransferase KAT6A / 0.707
3sxn COAN-acetyltransferase Eis / 0.704
1n71 COAAac(6')-Ii protein / 0.703
2c27 ACOMycothiol acetyltransferase 2.3.1.189 0.703
4zm6 ACON-acetyl-beta-D glucosaminidase / 0.703
1s5k COAAminoglycoside N(6')-acetyltransferase type 1 / 0.701
2psw COAN-alpha-acetyltransferase 50 / 0.699
3k9u ACOSpermidine N(1)-acetyltransferase / 0.699
1ozp ACOMycothiol acetyltransferase 2.3.1.189 0.697
2bue COAAAC(6')-Ib / 0.696
3pgp ACOUncharacterized protein / 0.696
5kf2 COAPredicted acetyltransferase / 0.696
5c88 COAN-alpha-acetyltransferase / 0.694
1s7n COAAcetyl transferase / 0.693
2bei ACODiamine acetyltransferase 2 2.3.1.57 0.690
3exn ACOProbable acetyltransferase / 0.690
3to6 LYS_CMCHistone acetyltransferase ESA1 / 0.690
4kub COAUncharacterized protein / 0.690
2vbq BSJAminoglycoside N(6')-acetyltransferase type 1 / 0.689
1j4j ACOAcetyltransferase 2.3.1 0.687
3f0a ACOSpermidine N(1)-acetyltransferase / 0.685
2cy2 ACOProbable acetyltransferase / 0.680
4kvx ACON-terminal acetyltransferase A complex catalytic subunit ard1 2.3.1.88 0.680
4xnh ACON-terminal acetyltransferase A complex subunit NAT5 2.3.1 0.680
1qsm ACOHistone acetyltransferase HPA2 / 0.679
3vwe COAAlpha-tubulin N-acetyltransferase 1 / 0.674
4b5o ACOAlpha-tubulin N-acetyltransferase 1 / 0.674
4mxe ACON-acetyltransferase ESCO1 2.3.1 0.671
3q33 ACOHistone acetyltransferase RTT109 2.3.1.48 0.669
4b14 NHWGlycylpeptide N-tetradecanoyltransferase / 0.669
3d2m COAAmino-acid acetyltransferase / 0.668
3d2p COAAmino-acid acetyltransferase / 0.667
1t3z CAOFormyl-CoA:oxalate CoA-transferase / 0.666
2bsw CAOProbable acetyltransferase / 0.665
3r96 ACOMccE protein / 0.665
5kf8 COAPredicted acetyltransferase / 0.664
2zfn ACOHistone acetyltransferase RTT109 2.3.1.48 0.661
1xa4 COAL-carnitine CoA-transferase / 0.660
3gya COAGCN5-related N-acetyltransferase / 0.660
2ft0 ACOdTDP-fucosamine acetyltransferase / 0.658
4qvt ACOAcetyltransferase YpeA 2.3.1 0.658
3vwd ACOAlpha-tubulin N-acetyltransferase 1 / 0.657
2jdd ACOProbable acetyltransferase / 0.656
2zpa ACOtRNA(Met) cytidine acetyltransferase TmcA / 0.654
2jdc CAOProbable acetyltransferase / 0.652
4r87 COASpermidine N(1)-acetyltransferase / 0.652
1s3z COAAminoglycoside N(6')-acetyltransferase type 1 / 0.650
3cz7 ACOHistone acetyltransferase RTT109 2.3.1.48 0.650