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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1mp8 ADP Focal adhesion kinase 1 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1mp8 ADPFocal adhesion kinase 1 2.7.10.2 0.956
1i44 ACPInsulin receptor 2.7.10.1 0.793
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.784
2ijm ATPFocal adhesion kinase 1 2.7.10.2 0.741
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.727
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.717
3a8w ATPProtein kinase C iota type 2.7.11.13 0.715
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.714
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.709
3orl AGSSerine/threonine protein kinase / 0.705
2pun ACPMethylthioribose kinase 2.7.1.100 0.701
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.698
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.697
4q5h ANPProtein kinase OspG 2.7 0.694
4xlv ACPInsulin receptor 2.7.10.1 0.694
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.692
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.691
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.690
4ax8 ADPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.689
3cly ACPFibroblast growth factor receptor 2 / 0.688
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.687
4o1p ANPRibonuclease L / 0.687
3g51 ANPRibosomal protein S6 kinase alpha-3 2.7.11.1 0.686
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.686
2olc ADPMethylthioribose kinase 2.7.1.100 0.684
4c3r ACPAurora kinase A 2.7.11.1 0.684
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.679
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.679
4q4c ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.678
3t9f ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.677
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.677
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.677
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.676
1q99 ANPSerine/threonine-protein kinase SKY1 2.7.11.1 0.673
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.673
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.673
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.672
1mq4 ADPAurora kinase A 2.7.11.1 0.670
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.670
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.670
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.669
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.669
4dee ADPAurora kinase A 2.7.11.1 0.669
2qoq ANPEphrin type-A receptor 3 2.7.10.1 0.668
3g8d ADPBiotin carboxylase 6.3.4.14 0.668
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.668
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.667
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.666
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.665
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.665
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.664
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.664
1tqp ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.662
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.662
2pul ACPMethylthioribose kinase 2.7.1.100 0.662
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.662
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.661
5ckw ANPUncharacterized protein / 0.661
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.660
3a7j ADPSerine/threonine-protein kinase 24 2.7.11.1 0.660
4ceg ADPAurora kinase A 2.7.11.1 0.660
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.660
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.659
1zao ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.658
3ung ADPCRISPR system Cmr subunit Cmr2 / 0.658
3wnz ADPAlanine--anticapsin ligase / 0.658
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.657
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.657
4dt8 ADNAPH(2'')-Id / 0.657
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.657
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.656
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.656
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.656
4pds ANPSerine/threonine-protein kinase RAD53 2.7.12.1 0.656
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.655
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.655
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.655
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.654
2w5b AGSSerine/threonine-protein kinase Nek2 2.7.11.1 0.654
1w2c ANPInositol-trisphosphate 3-kinase A 2.7.1.127 0.653
4oac ADPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.653
4ysj ADPCalmodulin-like domain protein kinase / 0.653
5drd ATPAurora kinase A 2.7.11.1 0.653
3c4w ATPRhodopsin kinase / 0.652
3mia ANPCyclin-dependent kinase 9 2.7.11.22 0.652
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.652
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.652
1sst COASerine acetyltransferase 2.3.1.30 0.651
2pyw ADPMethylthioribose kinase 2.7.1.100 0.651
3hko ANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands / 0.651
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.651
5l8l ADPAurora kinase A 2.7.11.1 0.651
2dxw SAHDiphthine synthase / 0.650
2e15 SAHDiphthine synthase / 0.650
2egb SAHDiphthine synthase / 0.650
2hut SAHDiphthine synthase / 0.650