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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1amo FAD NADPH--cytochrome P450 reductase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1amo FADNADPH--cytochrome P450 reductase / 1.274
3qe2 FADNADPH--cytochrome P450 reductase / 1.131
3qfc FADNADPH--cytochrome P450 reductase / 1.122
1ja1 FADNADPH--cytochrome P450 reductase / 1.119
4y9r FADNADPH--cytochrome P450 reductase / 1.104
4y9u FADNADPH--cytochrome P450 reductase / 1.081
3qfs FADNADPH--cytochrome P450 reductase / 1.071
4y7c FADNADPH--cytochrome P450 reductase / 1.069
4yaf FADNADPH--cytochrome P450 reductase / 1.058
4yau FADNADPH--cytochrome P450 reductase / 1.020
1j9z FADNADPH--cytochrome P450 reductase / 0.988
4yao FADNADPH--cytochrome P450 reductase / 0.947
1gaw FADFerredoxin / 0.940
1ja0 FADNADPH--cytochrome P450 reductase / 0.939
3ojw FADNADPH--cytochrome P450 reductase / 0.939
3qft FADNADPH--cytochrome P450 reductase / 0.935
3w2f FADNADH-cytochrome b5 reductase 3 1.6.2.2 0.931
3w5h FADNADH-cytochrome b5 reductase 3 1.6.2.2 0.924
3qfr FADNADPH--cytochrome P450 reductase / 0.922
3w2e FADNADH-cytochrome b5 reductase 3 1.6.2.2 0.921
1w35 FADFerredoxin--NADP reductase 1.18.1.2 0.919
4wqm FADToluene-4-monooxygenase electron transfer component 1.18.1.3 0.916
1fnd FADFerredoxin--NADP reductase, chloroplastic 1.18.1.2 0.912
1cqx FADFlavohemoprotein / 0.898
2bf4 FADNADPH--cytochrome P450 reductase / 0.897
1w34 FADFerredoxin--NADP reductase 1.18.1.2 0.894
1gaq FADFerredoxin / 0.891
2vyq FADFerredoxin--NADP reductase 1.18.1.2 0.888
1tll FADNitric oxide synthase, brain 1.14.13.39 0.887
2bn4 FADNADPH--cytochrome P450 reductase / 0.882
1qgy FADFerredoxin--NADP reductase 1.18.1.2 0.878
1umk FADNADH-cytochrome b5 reductase 3 1.6.2.2 0.875
3zc3 FADFerredoxin--NADP reductase 1.18.1.2 0.874
1h85 FADFerredoxin--NADP reductase 1.18.1.2 0.872
1i7p FADNADH-cytochrome b5 reductase 3 1.6.2.2 0.870
2rc5 FADFerredoxin--NADP reductase / 0.869
1qgz FADFerredoxin--NADP reductase 1.18.1.2 0.866
1b2r FADFerredoxin--NADP reductase 1.18.1.2 0.865
1qg0 FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic 1.18.1.2 0.865
2rc6 FADFerredoxin--NADP reductase / 0.863
2vnk FADNADPH:ferredoxin reductase / 0.861
1krh FADBenzoate 1,2-dioxygenase electron transfer component 1.18.1.3 0.860
1gjr FADFerredoxin--NADP reductase 1.18.1.2 0.855
2b5o FADFerredoxin--NADP reductase 1.18.1.2 0.855
2eix FADNADH-cytochrome b5 reductase / 0.854
1fnc FDAFerredoxin--NADP reductase, chloroplastic 1.18.1.2 0.853
1sm4 FADFerredoxin--NADP reductase / 0.849
2vnj FADNADPH:ferredoxin reductase / 0.849
1f20 FADNitric oxide synthase, brain 1.14.13.39 0.848
1fnb FADFerredoxin--NADP reductase, chloroplastic 1.18.1.2 0.846
4fk8 FADFerredoxin--NADP reductase / 0.843
4b4d FADFerredoxin-NADP reductase / 0.841
1qh0 FADFerredoxin--NADP reductase 1.18.1.2 0.840
2ok7 FADFerredoxin--NADP reductase, apicoplast / 0.840
3crz FADFerredoxin--NADP+ reductase / 0.840
1bx1 FADFerredoxin--NADP reductase, chloroplastic 1.18.1.2 0.838
2bpo FADNADPH--cytochrome P450 reductase / 0.837
3mhp FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic 1.18.1.2 0.832
1h42 FADFerredoxin--NADP reductase 1.18.1.2 0.830
1e63 FADFerredoxin--NADP reductase 1.18.1.2 0.828
1e62 FADFerredoxin--NADP reductase 1.18.1.2 0.827
1ogi FADFerredoxin--NADP reductase 1.18.1.2 0.827
1bx0 FADFerredoxin--NADP reductase, chloroplastic 1.18.1.2 0.824
1que FADFerredoxin--NADP reductase 1.18.1.2 0.823
3vo2 FADFerredoxin--NADP reductase / 0.823
1fdr FADFerredoxin--NADP reductase 1.18.1.2 0.822
4c43 FADFerredoxin--NADP reductase 1.18.1.2 0.822
1e64 FADFerredoxin--NADP reductase 1.18.1.2 0.817
4af6 FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic 1.18.1.2 0.815
2r6h FADNa(+)-translocating NADH-quinone reductase subunit F / 0.809
2xnc FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic 1.18.1.2 0.808
3fpk FADFerredoxin-NADP reductase / 0.807
1go2 FADFerredoxin--NADP reductase 1.18.1.2 0.806
1gr1 FADFerredoxin--NADP reductase 1.18.1.2 0.806
2vnh FADNADPH:ferredoxin reductase / 0.806
2bgi FADNADPH:ferredoxin reductase / 0.804
1w87 FADFerredoxin--NADP reductase 1.18.1.2 0.803
1ib0 FADNADH-cytochrome b5 reductase 3 1.6.2.2 0.801
2bgj FADNADPH:ferredoxin reductase / 0.798
1ogj FADFerredoxin--NADP reductase 1.18.1.2 0.795
4uaj FADNa(+)-translocating NADH-quinone reductase subunit F / 0.791
4bpr FADFerredoxin--NADP reductase 1.18.1.2 0.789
1bjk FADFerredoxin--NADP reductase 1.18.1.2 0.788
3zbt FADFerredoxin--NADP reductase 1.18.1.2 0.776
3ojx FADNADPH--cytochrome P450 reductase / 0.774
2qdx FADFerredoxin--NADP+ reductase / 0.769
2cnd FADNitrate reductase [NADH] 1.7.1.1 0.766
2pia FMNPhthalate dioxygenase reductase / 0.766
1ep3 FADDihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit / 0.762
3w5u FADFerredoxin / 0.758
4k1x FADNADPH:ferredoxin reductase / 0.756
3jqr FADFerredoxin--NADP reductase, apicoplast / 0.753
2ok8 FADFerredoxin--NADP reductase, apicoplast / 0.752
1ewy FADFerredoxin--NADP reductase 1.18.1.2 0.751
5cho FADFlavin reductase / 0.751
2gpj FADSiderophore-interacting protein / 0.745
1gvh FADFlavohemoprotein / 0.741
2ptf FMNUncharacterized protein MTH_863 / 0.731
4af7 FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic 1.18.1.2 0.728
3r5y F42Uncharacterized protein / 0.723
2i02 FMNPyridoxamine 5'-phosphate oxidase-related, FMN-binding / 0.721
3e4v FMNUncharacterized protein / 0.721
1i0s FMNFerric-chelate reductase (NAD(P)H) / 0.712
4f07 FADStyrene monooxygenase component 2 / 0.710
1usc FMNMonooxygenase / 0.704
2hq9 FADMll6688 protein / 0.703
1a8p FADFerredoxin--NADP reductase / 0.701
4ylf FADDihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit homolog / 0.699
1pkv RBFRiboflavin synthase 2.5.1.9 0.692
2i0z FADNAD(FAD)-utilizing dehydrogenases / 0.692
2iml FMNUncharacterized protein / 0.692
3r5z F42Uncharacterized protein / 0.692
4hmx FMNPyridoxamine 5'-phosphate oxidase / 0.692
3bnk FMNFlavoredoxin / 0.691
1wlk FMNFMN-binding protein / 0.689
4hj4 FMNLOV protein / 0.683
4ybn FADFlavin-nucleotide-binding protein / 0.683
4hms FMNPhenazine biosynthesis protein PhzG 1.4 0.678
1cnf FADNitrate reductase [NADH] 1.7.1.1 0.676
2ign FADPyranose 2-oxidase / 0.676
3a20 FMNFMN-binding protein / 0.675
4rhe FMNFlavin prenyltransferase UbiX / 0.674
1eje FMNProtein MTH_152 / 0.673
1rz0 FADPhenol 2-hydroxylase component B / 0.671
2i51 FMNPyridoxamine 5'-phosphate oxidase-related, FMN-binding / 0.671
4mok FADPyranose 2-oxidase / 0.670
2nr4 FMNConserved protein / 0.668
3lsm SFDPyranose 2-oxidase / 0.667
3lov FADProtoporphyrinogen oxidase / 0.665
1ndh FADNADH-cytochrome b5 reductase 3 1.6.2.2 0.661
3urh FADDihydrolipoyl dehydrogenase / 0.661
2ard FDAFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.659
1icu FMNOxygen-insensitive NAD(P)H nitroreductase / 0.658
3in6 FMNUncharacterized protein / 0.657
3a6r FMNFMN-binding protein / 0.655
3sfe FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.655
4hmw FMNPyridoxamine 5'-phosphate oxidase / 0.654
1icv FMNOxygen-insensitive NAD(P)H nitroreductase / 0.653
2igo FADPyranose 2-oxidase / 0.653
3ept FDAPutative FAD-monooxygenase / 0.653
1n07 FMNRiboflavin kinase 2.7.1.26 0.650
3clt FADElectron transfer flavoprotein subunit alpha / 0.650