sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 5kf2 | COA | Predicted acetyltransferase |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 5kf2 | COA | Predicted acetyltransferase | / | 1.000 | |
| 5kf9 | COA | Predicted acetyltransferase | / | 0.597 | |
| 1n71 | COA | Aac(6')-Ii protein | / | 0.571 | |
| 2wpw | ACO | Orf14 | / | 0.526 | |
| 4ag7 | COA | Glucosamine 6-phosphate N-acetyltransferase | / | 0.524 | |
| 5kf1 | COA | Predicted acetyltransferase | / | 0.521 | |
| 3f0a | ACO | Spermidine N(1)-acetyltransferase | / | 0.517 | |
| 4u9v | ACO | N-alpha-acetyltransferase 40 | 2.3.1 | 0.512 | |
| 2cy2 | ACO | Probable acetyltransferase | / | 0.505 | |
| 1b87 | ACO | Aac(6')-Ii protein | / | 0.504 | |
| 4cs0 | ACO | PanD regulatory factor | / | 0.501 | |
| 4cry | ACO | PanD regulatory factor | / | 0.499 | |
| 4mxe | ACO | N-acetyltransferase ESCO1 | 2.3.1 | 0.495 | |
| 4b5o | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.487 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.486 | |
| 4h6z | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.483 | |
| 4b5p | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.482 | |
| 4at4 | T6E | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.480 | |
| 5kf8 | COA | Predicted acetyltransferase | / | 0.480 | |
| 3tfy | COA | N-alpha-acetyltransferase 50 | 2.3.1 | 0.476 | |
| 4ag9 | COA | Glucosamine 6-phosphate N-acetyltransferase | / | 0.476 | |
| 3njo | PYV | Abscisic acid receptor PYR1 | / | 0.475 | |
| 4h6u | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.474 | |
| 4crz | ACO | PanD regulatory factor | / | 0.473 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.471 | |
| 5i2h | AGI | O-methyltransferase family 2 | / | 0.470 | |
| 4hkf | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.468 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.466 | |
| 2ewa | SB2 | Mitogen-activated protein kinase 14 | / | 0.466 | |
| 2jc6 | QPP | Calcium/calmodulin-dependent protein kinase type 1D | 2.7.11.17 | 0.464 | |
| 3vwe | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.464 | |
| 4if5 | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.464 | |
| 1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.463 | |
| 3ngl | NAP | Bifunctional protein FolD | / | 0.463 | |
| 4ajm | 3A6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.463 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.462 | |
| 2b1z | 17M | Estrogen receptor | / | 0.461 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.461 | |
| 2vez | ACO | Glucosamine 6-phosphate acetyltransferase, putative | / | 0.459 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.458 | |
| 1xng | DND | NH(3)-dependent NAD(+) synthetase | 6.3.1.5 | 0.456 | |
| 4blc | NDP | Catalase | 1.11.1.6 | 0.456 | |
| 4gs4 | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.456 | |
| 5kf9 | ACO | Predicted acetyltransferase | / | 0.456 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.452 | |
| 5kf2 | ACO | Predicted acetyltransferase | / | 0.452 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.451 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.451 | |
| 3djl | FAD | Putative acyl-CoA dehydrogenase AidB | 1.3.99 | 0.451 | |
| 3elm | 24F | Collagenase 3 | 3.4.24 | 0.451 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.451 | |
| 1olm | VTQ | SEC14-like protein 2 | / | 0.450 | |
| 3kr6 | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.450 | |
| 3sl6 | JN8 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.450 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.450 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.450 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.449 | |
| 4eqr | FAD | Coenzyme A disulfide reductase | / | 0.449 | |
| 4equ | G6I | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.449 | |
| 4u9y | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.449 | |
| 3upk | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.448 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.448 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.447 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 1dgb | NDP | Catalase | 1.11.1.6 | 0.445 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 1ai9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 1uae | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.444 | |
| 2pl0 | STI | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.444 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 3oll | EST | Estrogen receptor beta | / | 0.444 | |
| 4fk3 | 325 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.444 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.443 | |
| 2jdc | CAO | Probable acetyltransferase | / | 0.443 | |
| 4keb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.442 | |
| 2g2h | P16 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.442 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 5kgp | ACO | Predicted acetyltransferase | / | 0.442 | |
| 2bbq | PFG | Thymidylate synthase | / | 0.441 | |
| 3c3d | FO1 | 2-phospho-L-lactate transferase | / | 0.441 | |
| 3p9t | TCL | Repressor | / | 0.441 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.441 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.440 | |
| 3nxy | D2H | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3pgp | ACO | Uncharacterized protein | / | 0.440 |