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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5e72SAMN2, N2-dimethylguanosine tRNA methyltransferase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity
Align
5e72SAMN2, N2-dimethylguanosine tRNA methyltransferase/1.000
2zifSAMMethyltransferase/0.518
3qv2SAH5-cytosine DNA methyltransferase/0.508
3pt9SAHDNA (cytosine-5)-methyltransferase 12.1.1.370.502
2eg5SAH7-methylxanthosine synthase 1/0.493
3ldfSAHUncharacterized protein/0.489
2oreSAHDNA adenine methylase2.1.1.720.488
3sr4TT8Histone-lysine N-methyltransferase, H3 lysine-79 specific2.1.1.430.487
3nu3478Gag-Pol polyprotein3.4.23.160.485
4rtrSAMDNA adenine methylase2.1.1.720.484
4u7tSAHDNA (cytosine-5)-methyltransferase 3A2.1.1.370.484
2np7NEAModification methylase TaqI2.1.1.720.483
1nv8SAMRelease factor glutamine methyltransferase2.1.1.2970.482
1vikBAYGag-Pol polyprotein/0.482
1difA85Gag-Pol polyprotein/0.480
1sg9SAMRelease factor glutamine methyltransferase2.1.1.2970.479
1skmSAHModification methylase HhaI2.1.1.370.478
1qbu846Gag-Pol polyprotein3.4.23.160.476
4mwzSAMPhosphoethanolamine N-methyltransferase, putative/0.476
3upjU03Gag-Pol polyprotein/0.475
4onqSFGDNA methyltransferase/0.475
4h0nSAHDnmt2/0.474
3s43478Protease/0.473
4nmbFADBifunctional protein PutA/0.473
3oxv478Gag-Pol polyprotein3.4.23.160.472
3dcrKVSProtease/0.471
4fr0SAMArsenic methyltransferase/0.471
3ldgSAHUncharacterized protein/0.470
1w5vBE3Gag-Pol polyprotein3.4.23.160.469
2ih2NEAModification methylase TaqI2.1.1.720.469
4hdpG52Gag-Pol polyprotein3.4.23.160.469
4rtlSFGDNA adenine methylase2.1.1.720.469
1ivq0PXGag-Pol polyprotein/0.468
3djkG55Gag-Pol polyprotein3.4.23.160.468
3nu5478Gag-Pol polyprotein3.4.23.160.468
1c3eNHRPhosphoribosylglycinamide formyltransferase/0.467
1d4sTPVGag-Pol polyprotein3.4.23.160.467
1hvrXK2Gag-Pol polyprotein/0.467
3a25SAMtRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase/0.467
4a862ANMajor pollen allergen Bet v 1-A/0.467
5e8jSAHmRNA cap guanine-N7 methyltransferase2.1.1.560.467
1npa3NHGag-Pol polyprotein3.4.23.160.466
1npwLGZGag-Pol polyprotein3.4.23.160.466
2upjU02Gag-Pol polyprotein3.4.23.160.466
3lstSAHCalO1/0.466
4dfg0JVGag-Pol polyprotein3.4.23.160.466
1d4jMSCGag-Pol polyprotein3.4.23.160.465
2rkfAB1Pol protein/0.465
3s54017Protease/0.465
1hpoUNIGag-Pol polyprotein3.4.23.160.464
2bpv1INGag-Pol polyprotein3.4.23.160.464
4l4xNDPAmphI/0.464
5fa8SAMRibosomal protein L11 methyltransferase, putative/0.464
10mhSAHModification methylase HhaI2.1.1.370.463
1g35AHFGag-Pol polyprotein3.4.23.160.463
1t7kBH0Gag-Pol polyprotein3.4.23.160.463
2bqvA1AProtease/0.463
2qnqQN3Gag-Pol polyprotein3.4.23.160.463
1dw60Q4Gag-Pol polyprotein3.4.23.160.462
2pwcG3GGag-Pol polyprotein3.4.23.160.462
2r43G3GGag-Pol polyprotein3.4.23.160.462
2w6nOA2Biotin carboxylase6.3.4.140.462
3vfa031Gag-Pol polyprotein3.4.23.160.462
2qak1UNGag-Pol polyprotein3.4.23.160.461
2b7zMK1Gag-Pol polyprotein/0.460
2fde385Gag-Pol polyprotein3.4.23.160.460
3uj7SAMPhosphoethanolamine N-methyltransferase/0.460
3v97SAHRibosomal RNA large subunit methyltransferase K/L2.1.1.1730.460
4geb0LDKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.460
2fxeDR7Gag-Pol polyprotein3.4.23.160.459
3lzu017Gag-Pol polyprotein3.4.23.160.459
4blwSAHRibosomal RNA large subunit methyltransferase J/0.459
1ec3MS3Gag-Pol polyprotein3.4.23.160.458
2qd8065Gag-Pol polyprotein3.4.23.160.458
2r5q1UNGag-Pol polyprotein/0.458
3gi6D78Gag-Pol polyprotein/0.458
3own3OWRenin3.4.23.150.458
4a86H35Major pollen allergen Bet v 1-A/0.458
4j55031Gag-Pol polyprotein3.4.23.160.458
4rtpSAMDNA adenine methylase2.1.1.720.458
1dz6CAMCamphor 5-monooxygenase1.14.15.10.457
1fff0Q4Gag-Pol polyprotein3.4.23.160.457
1hvsA77Gag-Pol polyprotein/0.457
2aquDR7Gag-Pol polyprotein3.4.23.160.457
2bb9AKCGag-Pol polyprotein3.4.23.160.457
2f3kRO1Protease/0.457
2pqzG0GGag-Pol polyprotein3.4.23.160.457
2qd7065Gag-Pol polyprotein3.4.23.160.457
3ekwDR7Gag-Pol polyprotein3.4.23.160.457
3l0lHC3Nuclear receptor ROR-gamma/0.457
3lbySAHUncharacterized protein/0.457
3ndwRITGag-Pol polyprotein3.4.23.160.457
4da4SAHDNA (cytosine-5)-methyltransferase 12.1.1.370.457
2gd2CAAProbable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase )/0.456
2i4xKGQProtease/0.456
2q641UNGag-Pol polyprotein3.4.23.160.456
4j5j478Gag-Pol polyprotein3.4.23.160.456
6upjNIUGag-Pol polyprotein/0.456
9mhtSAHModification methylase HhaI2.1.1.370.456
1vq1SAMRelease factor glutamine methyltransferase2.1.1.2970.455
2fdd385Pol protein/0.455
3el51UNGag-Pol polyprotein/0.455
3pt6SAHDNA (cytosine-5)-methyltransferase 12.1.1.370.455
4gkvNADAlcohol dehydrogenase, propanol-preferring1.1.1.10.455
4klrCHDFerrochelatase, mitochondrial4.99.1.10.455
1odyLP1Gag-Pol polyprotein3.4.23.160.454
1wbmBLLPol protein/0.454
2om9AJAPeroxisome proliferator-activated receptor gamma/0.454
2r5pMK1Gag-Pol polyprotein/0.454
3lzv017Gag-Pol polyprotein3.4.23.160.454
4ib4ERM5-hydroxytryptamine receptor 2B/0.454
4upjU04Gag-Pol polyprotein/0.454
5mhtSAHModification methylase HhaI2.1.1.370.454
1ia3TQ5Dihydrofolate reductase1.5.1.30.453
1msmJE2Gag-Pol polyprotein3.4.23.160.453
2fxdDR7Pol polyprotein/0.453
2hs1017Protease/0.453
3bgbLJGGag-Pol polyprotein3.4.23.160.453
3cktYDPGag-Pol polyprotein3.4.23.160.453
3grrSAHProbable ribosomal RNA small subunit methyltransferase A/0.453
1idb0DOGag-Pol polyprotein/0.452
2hs2017Protease/0.452
3adaNADSubunit alpha of sarocosine oxidase/0.452
3d84NDPDihydrofolate reductase1.5.1.30.452
3jvwDMPGag-Pol polyprotein3.4.23.160.452
3nuo478Gag-Pol polyprotein3.4.23.160.452
3t54ATPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2/0.452
1bveDMPGag-Pol polyprotein3.4.23.160.451
1bwb146Gag-Pol polyprotein3.4.23.160.451
1wbk568Pol protein/0.451
2gr1FADFerredoxin reductase/0.451
2ibtNEAModification methylase TaqI2.1.1.720.451
3ndxRITGag-Pol polyprotein3.4.23.160.451
3nuj478Gag-Pol polyprotein3.4.23.160.451
3o9aK14Pol polyprotein/0.451
3p9kSAHCaffeic acid O-methyltransferase/0.451
3ttp017Gag-Pol polyprotein3.4.23.160.451
4a6cQG9Gag-Pol polyprotein3.4.23.160.451
5es7FONLinear gramicidin synthase subunit A/0.451
1u7tTDT3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.450
2bpy3INGag-Pol polyprotein3.4.23.160.450
2j3iNAPNADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.450
2wl05AHGag-Pol polyprotein/0.450
4h1e10JBeta-secretase 13.4.23.460.450
5bp9SAHPutative methyltransferase protein/0.450
1gthFADDihydropyrimidine dehydrogenase [NADP(+)]1.3.1.20.449
1k6cMK1Gag-Pol polyprotein3.4.23.160.449
2bpz3INGag-Pol polyprotein3.4.23.160.449
2hmySAMModification methylase HhaI2.1.1.370.449
2qci065Gag-Pol polyprotein3.4.23.160.449
2qe6SAMUncharacterized protein/0.449
3bgcLJHGag-Pol polyprotein3.4.23.160.449
3kddJZQGag-Pol polyprotein3.4.23.160.449
3nu4478Gag-Pol polyprotein3.4.23.160.449
3v04V04Dual specificity mitogen-activated protein kinase kinase 12.7.12.20.449
3vfb031Gag-Pol polyprotein3.4.23.160.449
4j54G52Gag-Pol polyprotein3.4.23.160.449
4qtuSAM18S rRNA (guanine(1575)-N(7))-methyltransferase/0.449
1bwaXV6Gag-Pol polyprotein3.4.23.160.448
1hiiC20Gag-Pol polyprotein/0.448
1qbt146Gag-Pol polyprotein3.4.23.160.448
1rbyGARTrifunctional purine biosynthetic protein adenosine-32.1.2.20.448
1z1rHBHGag-Pol polyprotein3.4.23.160.448
2cej1AHPol protein/0.448
2jb4A14Isopenicillin N synthase1.21.3.10.448
2qi7MZ9Gag-Pol polyprotein/0.448
3cinNADMyo-inositol-1-phosphate synthase-related protein/0.448
3stv3HOMethylketone synthase I/0.448
3vf5031Gag-Pol polyprotein3.4.23.160.448
3wv9FEGHmd co-occurring protein HcgE/0.448
4a6bQG8Gag-Pol polyprotein3.4.23.160.448
5ccbSAHtRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A2.1.1.2200.448
3uzcT4EAdenosine receptor A2a/0.448
1ec2BEJGag-Pol polyprotein3.4.23.160.447
1fjxSAHModification methylase HhaI2.1.1.370.447
1mesDMPGag-Pol polyprotein3.4.23.160.447
1sdvMK1Gag-Pol polyprotein3.4.23.160.447
2tctCTCTetracycline repressor protein class D/0.447
3el4ROCGag-Pol polyprotein3.4.23.160.447
4knzCB3Thymidylate synthase/0.447
4rtmSAMDNA adenine methylase2.1.1.720.447
5epeSAHUncharacterized protein/0.447
1d4kPI8Gag-Pol polyprotein3.4.23.160.446
2drcMTXDihydrofolate reductase1.5.1.30.446
2nu9COASuccinate--CoA ligase [ADP-forming] subunit alpha6.2.1.50.446
3gc9B45Mitogen-activated protein kinase 112.7.11.240.446
3gi4K60Gag-Pol polyprotein/0.446
3i7eDJRGag-Pol polyprotein/0.446
4rtqSAHDNA adenine methylase2.1.1.720.446
4xiwAZMCarbonic anhydrase, alpha type/0.446
4y93746Tyrosine-protein kinase/0.446
1ff02NCGag-Pol polyprotein3.4.23.160.445
1hshMK1Gag-Pol polyprotein/0.445
1qbsDMPGag-Pol polyprotein3.4.23.160.445
1xl5190Gag-Pol polyprotein3.4.23.160.445
2a41ATPActin, alpha skeletal muscle/0.445
2ieo017Protease/0.445
2j5xGSPADP-ribosylation factor 6/0.445
3imxB84Glucokinase2.7.1.20.445
3iqfE4MF420-dependent methylenetetrahydromethanopterin dehydrogenase1.5.98.10.445
3mws017Pol protein/0.445
3u4lATPActin, cytoplasmic 1/0.445
3zptM8YGag-Pol polyprotein3.4.23.160.445
4q1y017Gag-Pol polyprotein3.4.23.160.445
1c70L75Protease/0.444
1s9dAFBCytohesin-2/0.444
1s9dAFBADP-ribosylation factor 1/0.444
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
3inmNDPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.444
1c6zROCProtease/0.443
1k6tXN1Gag-Pol polyprotein3.4.23.160.443
1rc0KT5Trifunctional purine biosynthetic protein adenosine-32.1.2.20.443
1sbgIM1Gag-Pol polyprotein/0.443
1t88CAMCamphor 5-monooxygenase1.14.15.10.443
2gd0MRSProbable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase )/0.443
2pyn1UNGag-Pol polyprotein3.4.23.160.443
2qd6065Gag-Pol polyprotein3.4.23.160.443
2qnpQN2Gag-Pol polyprotein3.4.23.160.443
3aidARQGag-Pol polyprotein3.4.23.160.443
3d1z017Gag-Pol polyprotein3.4.23.160.443
3ekx1UNGag-Pol polyprotein3.4.23.160.443
3own3OXRenin3.4.23.150.443
3ruvANPChaperonin/0.443
4dqh017Gag-Pol polyprotein/0.443
4liiFADApoptosis-inducing factor 1, mitochondrial1.1.10.443
4rtjSFGDNA adenine methylase2.1.1.720.443
1b6pPI7Gag-Pol polyprotein3.4.23.160.442
1c3eGARPhosphoribosylglycinamide formyltransferase/0.442
1ie8KH1Vitamin D3 receptor/0.442
1jld0PPGag-Pol polyprotein/0.442
1njsKEUTrifunctional purine biosynthetic protein adenosine-32.1.2.20.442
1sivPSIGag-Pol polyprotein/0.442
1yrdCAMCamphor 5-monooxygenase1.14.15.10.442
2p8uCOAHydroxymethylglutaryl-CoA synthase, cytoplasmic2.3.3.100.442
2q1l8823-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.340.442
3b7dCNIGlutamate receptor 2/0.442
3em3478Gag-Pol polyprotein3.4.23.160.442
3em4DR7Gag-Pol polyprotein3.4.23.160.442
3ggaGGWGag-Pol polyprotein/0.442
3hzc2NCProtease/0.442
3oafOAGDihydrofolate reductase1.5.1.30.442
3t113T1Gag-Pol polyprotein3.4.23.160.442
4djy0KRBeta-secretase 13.4.23.460.442
4g2gTDHMycocyclosin synthase1.14.21.90.442
4l4dCAMCamphor 5-monooxygenase1.14.15.10.442
4nb6444Nuclear receptor ROR-gamma/0.442
4qgiROCGag-Pol polyprotein3.4.23.160.442
4rtoSFGDNA adenine methylase2.1.1.720.442
1d4lPI9Gag-Pol polyprotein3.4.23.160.441
1d4yTPVGag-Pol polyprotein3.4.23.160.441
1ivp1ZKGag-Pol polyprotein/0.441
1wbsLI2Mitogen-activated protein kinase 14/0.441
1wbtWBTMitogen-activated protein kinase 14/0.441
1zsr0ZTGag-Pol polyprotein3.4.23.160.441
2bktRPFRenin3.4.23.150.441
2g1pSAHDNA adenine methylase2.1.1.720.441
2is0I03Beta-secretase 13.4.23.460.441
2vzmNRBCytochrome P450 monooxygenase PikC/0.441
3a9wNADNDP-sugar epimerase/0.441
3d1yROCGag-Pol polyprotein3.4.23.160.441
3dzvADPHydroxyethylthiazole kinase/0.441
3uhl2NCGag-Pol polyprotein3.4.23.160.441
4eplJAIJasmonic acid-amido synthetase JAR16.3.20.441
4k42ADPActin, alpha skeletal muscle/0.441
4ylfFADDihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit homolog/0.441
1d4iBEGGag-Pol polyprotein3.4.23.160.440
1dkfBMSRetinoic acid receptor alpha/0.440
1kyzFERCaffeic acid 3-O-methyltransferase2.1.1.680.440
2aqkNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
2f80017Gag-Pol polyprotein3.4.23.160.440
2f8lSAMLmo1582 protein/0.440
2r3tG4GGag-Pol polyprotein3.4.23.160.440
3egvSAHRibosomal protein L11 methyltransferase2.1.10.440
3em6017Gag-Pol polyprotein3.4.23.160.440
3f6sFMNFlavodoxin/0.440
3pdqKC6Lysine-specific demethylase 4A1.14.110.440
3sa9A68Protease/0.440
3tm4SAMUncharacterized protein/0.440
3w33W19Epidermal growth factor receptor2.7.10.10.440
4dfrMTXDihydrofolate reductase1.5.1.30.440
4djr0KJPol polyprotein/0.440
4ejmNAPPutative zinc-binding dehydrogenase/0.440
4ktl1CQCytochrome P450/0.440
4obwSAM2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial/0.440
4rtnSAHDNA adenine methylase2.1.1.720.440