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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4xc0ACPHeat shock cognate 90 kDa protein

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4xc0ACPHeat shock cognate 90 kDa protein/1.000
3ekrPY9Heat shock protein HSP 90-alpha/0.509
3rlq3RQHeat shock protein HSP 90-alpha/0.509
1yszNECEndoplasmin/0.488
3r4pFU7Heat shock protein HSP 90-alpha/0.469
2wepADPATP-dependent molecular chaperone HSP82/0.463
3ekoPYUHeat shock protein HSP 90-alpha/0.463
3hekBD0Heat shock protein HSP 90-alpha/0.462
4bqjXKLHeat shock protein HSP 90-alpha/0.461
4fcr0TMHeat shock protein HSP 90-alpha/0.460
3k974CDHeat shock protein HSP 90-alpha/0.459
2xcmADPCytosolic heat shock protein 90/0.457
2yegXQGHeat shock protein HSP 90-alpha/0.456
4xclAGSHeat shock cognate 90 kDa protein/0.456
2werRDCATP-dependent molecular chaperone HSP82/0.452
1u2oNECEndoplasmin/0.444
2gfdRDAEndoplasmin/0.444
2gqpPA7Endoplasmin/0.444
3r4nFU5Heat shock protein HSP 90-alpha/0.444
4xcjADPHeat shock cognate 90 kDa protein/0.444
1y4sADPChaperone protein HtpG/0.443
2qg0A94Heat shock protein HSP 90-alpha/0.443
2xabVHDHeat shock protein HSP 90-alpha/0.440