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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4gtp7TPProtein farnesyltransferase subunit beta2.5.1.58

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4gtp7TPProtein farnesyltransferase subunit beta2.5.1.581.000
3eu5GBOProtein farnesyltransferase subunit beta2.5.1.580.649
1ld8U49Protein farnesyltransferase subunit beta2.5.1.580.645
1sa5BMVProtein farnesyltransferase subunit beta2.5.1.580.634
1n95FTHProtein farnesyltransferase subunit beta2.5.1.580.629
1n95HFPProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.628
1n95HFPProtein farnesyltransferase subunit beta2.5.1.580.628
1mzcBNEProtein farnesyltransferase subunit beta2.5.1.580.625
3e32ED2Protein farnesyltransferase subunit beta2.5.1.580.624
1sa4JANProtein farnesyltransferase subunit beta2.5.1.580.623
1ld7U66Protein farnesyltransferase subunit beta2.5.1.580.622
1s63778Protein farnesyltransferase subunit beta2.5.1.580.619
3e33ED7Protein farnesyltransferase subunit beta2.5.1.580.618
1jcq739Protein farnesyltransferase subunit beta2.5.1.580.615
3e30ED4Protein farnesyltransferase subunit beta2.5.1.580.608
4gtr7TRProtein farnesyltransferase subunit beta2.5.1.580.608
1o1s1NHProtein farnesyltransferase subunit beta2.5.1.580.595
4gtm7TMProtein farnesyltransferase subunit beta2.5.1.580.593
3ksqZ96Protein farnesyltransferase subunit beta2.5.1.580.566
3pz43PZProtein farnesyltransferase subunit beta2.5.1.580.563
1nl4HFPProtein farnesyltransferase subunit beta2.5.1.580.560
2h6iCYS_VAL_LEU_SER_GERProtein farnesyltransferase subunit beta2.5.1.580.538
1n4sCYS_VAL_ILE_LEU_GERGeranylgeranyl transferase type-1 subunit beta2.5.1.590.529
2r2lPB9Protein farnesyltransferase subunit beta2.5.1.580.523
1n4qLYS_CYS_VAL_ILE_LEUGeranylgeranyl transferase type-1 subunit beta2.5.1.590.513
1s64778Geranylgeranyl transferase type-1 subunit beta2.5.1.590.499
3pz23PZGeranylgeranyl transferase type-2 subunit beta2.5.1.600.498
3hxfBD9Geranylgeranyl transferase type-2 subunit beta2.5.1.600.495
1qbqHFPProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.492
1qbqHFPProtein farnesyltransferase subunit beta2.5.1.580.492
4gto7TOProtein farnesyltransferase subunit beta2.5.1.580.477
3q7fED2Uncharacterized protein/0.460
1ni12C5Protein farnesyltransferase subunit beta2.5.1.580.442