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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4emjFADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component1.18.1.3

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4emjFADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component1.18.1.31.000
3ef6FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component1.18.1.30.608
4h4vFADBiphenyl dioxygenase ferredoxin reductase subunit/0.515
4h4pFADBiphenyl dioxygenase ferredoxin reductase subunit/0.502
2gr3FADFerredoxin reductase/0.498
4h4sFADBiphenyl dioxygenase ferredoxin reductase subunit/0.494
5fs6FADApoptosis-inducing factor 1, mitochondrial1.1.10.479
5fs8FADApoptosis-inducing factor 1, mitochondrial1.1.10.475
4liiFADApoptosis-inducing factor 1, mitochondrial1.1.10.462
3gd3FADApoptosis-inducing factor 1, mitochondrial1.1.10.456
3lb8FADPutidaredoxin reductase1.18.1.50.452
1gv4FADApoptosis-inducing factor 1, mitochondrial1.1.10.447
4h50FADBiphenyl dioxygenase ferredoxin reductase subunit/0.447
5fs7FADApoptosis-inducing factor 1, mitochondrial1.1.10.442
3lxdFADFAD-dependent pyridine nucleotide-disulfide oxidoreductase/0.441