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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4dn5AGSMitogen-activated protein kinase kinase kinase 142.7.11.25

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4dn5AGSMitogen-activated protein kinase kinase kinase 142.7.11.251.000
4idtT28Mitogen-activated protein kinase kinase kinase 142.7.11.250.549
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.531
1o6yACPSerine/threonine-protein kinase PknB2.7.11.10.524
5dt3ATPAurora kinase A2.7.11.10.523
5drdATPAurora kinase A2.7.11.10.510
4utdACPAurora kinase A2.7.11.10.507
4k33ACPFibroblast growth factor receptor 32.7.10.10.506
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.506
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.499
3ttjJBIMitogen-activated protein kinase 102.7.11.240.492
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.490
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.490
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.488
4fl3ANPTyrosine-protein kinase SYK2.7.10.20.488
3zlyYSODual specificity mitogen-activated protein kinase kinase 12.7.12.20.487
3oroAGSSerine/threonine protein kinase/0.486
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.485
3oriAGSSerine/threonine protein kinase/0.484
3gubGUBDeath-associated protein kinase 12.7.11.10.483
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.482
4jboWPHAurora kinase A2.7.11.10.482
3ormAGSSerine/threonine protein kinase/0.481
5dnrATPAurora kinase A2.7.11.10.481
1ol7ADPAurora kinase A2.7.11.10.480
3a60STURibosomal protein S6 kinase beta-12.7.11.10.480
3i60E86Mitogen-activated protein kinase 12.7.11.240.480
3zm422TDual specificity mitogen-activated protein kinase kinase 12.7.12.20.480
4zseANPEpidermal growth factor receptor2.7.10.10.480
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.478
4qpmADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.478
4w9wYDJBMP-2-inducible protein kinase2.7.11.10.478
3gxlQIGTGF-beta receptor type-12.7.11.300.477
1pyxANPGlycogen synthase kinase-3 beta2.7.11.260.476
4idv13VMitogen-activated protein kinase kinase kinase 142.7.11.250.476
5dn3ATPAurora kinase A2.7.11.10.475
1ol5ADPAurora kinase A2.7.11.10.474
2dwbANPAurora kinase A2.7.11.10.474
3w18N13Aurora kinase A2.7.11.10.473
2uzlC94Cyclin-dependent kinase 22.7.11.220.472
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.472
3k5uPFQAurora kinase A2.7.11.10.471
4jbpYPHAurora kinase A2.7.11.10.470
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.470
5auuLU2Death-associated protein kinase 12.7.11.10.470
2qboCAMCamphor 5-monooxygenase1.14.15.10.469
3gu5ANPDeath-associated protein kinase 12.7.11.10.469
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.469
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.469
5dt4ATPAurora kinase A2.7.11.10.469
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.468
1mq4ADPAurora kinase A2.7.11.10.467
2c6tDT5Cyclin-dependent kinase 22.7.11.220.467
1pkgADPMast/stem cell growth factor receptor Kit2.7.10.10.466
3l8p0CEAngiopoietin-1 receptor2.7.10.10.465
3zlx5EZDual specificity mitogen-activated protein kinase kinase 12.7.12.20.465
1oi9N20Cyclin-dependent kinase 22.7.11.220.464
3hmm855TGF-beta receptor type-12.7.11.300.464
1ha3MAUElongation factor Tu-A/0.463
2hog710Serine/threonine-protein kinase Chk12.7.11.10.463
5awmANPStress-activated protein kinase JNK2.7.11.240.463
2c3kABOSerine/threonine-protein kinase Chk12.7.11.10.462
4e4m0NHTyrosine-protein kinase JAK2/0.462
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.462
1ol6ATPAurora kinase A2.7.11.10.461
2qo9ANPEphrin type-A receptor 32.7.10.10.461
4r8qADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.461
1gih1PUCyclin-dependent kinase 22.7.11.220.460
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.460
2xneASHAurora kinase A2.7.11.10.460
3le62BZCyclin-dependent kinase 22.7.11.220.460
4jr7GNPCasein kinase II subunit alpha2.7.11.10.460
1ir3ANPInsulin receptor2.7.10.10.459
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.459
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.459
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.458
2x1nX1NCyclin-dependent kinase 22.7.11.220.457
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.457
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.457
4qnyANPMitogen activated protein kinase, putative/0.457
5dosATPAurora kinase A2.7.11.10.457
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.456
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.456
3c50ADPRhodopsin kinase/0.456
4dgo0JWCasein kinase II subunit alpha2.7.11.10.456
4gvjADPNon-receptor tyrosine-protein kinase TYK22.7.10.20.456
5e8wSTUTGF-beta receptor type-12.7.11.300.456
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.455
2o65MYFSerine/threonine-protein kinase pim-12.7.11.10.455
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.454
3uli1N3Cyclin-dependent kinase 22.7.11.220.454
4o0uADNAurora kinase A2.7.11.10.454
5cvcPLPSerine racemase/0.454
4jbqVX6Aurora kinase A2.7.11.10.453
1rw8580TGF-beta receptor type-12.7.11.300.452
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.452
5dr2ATPAurora kinase A2.7.11.10.452
5e92ANPTGF-beta receptor type-22.7.11.300.452
2xikJ60Serine/threonine-protein kinase 252.7.11.10.451
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.451
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.451
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.451
6cp4CAMCamphor 5-monooxygenase1.14.15.10.451
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.450
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.450
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.450
4gfo0X2Non-receptor tyrosine-protein kinase TYK22.7.10.20.450
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.449
2h96893Mitogen-activated protein kinase 82.7.11.240.449
2iw84SPCyclin-dependent kinase 22.7.11.220.449
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.449
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.449
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.449
1oiyN41Cyclin-dependent kinase 22.7.11.220.448
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.448
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.448
4cegADPAurora kinase A2.7.11.10.448
4oaeCLMUncharacterized protein/0.448
1lp4ANPCasein kinase II subunit alpha2.7.11.10.447
2vxoXMPGMP synthase [glutamine-hydrolyzing]6.3.5.20.447
2zdt46CMitogen-activated protein kinase 102.7.11.240.447
4fob0USALK tyrosine kinase receptor2.7.10.10.447
4g170VNCasein kinase I isoform gamma-32.7.11.10.447
4jqeANPCasein kinase II subunit alpha2.7.11.10.447
4qmpDKISerine/threonine-protein kinase 242.7.11.10.447
4y93746Tyrosine-protein kinase/0.447
1aq1STUCyclin-dependent kinase 22.7.11.220.446
1q8yADPSerine/threonine-protein kinase SKY12.7.11.10.446
1u4dDBQActivated CDC42 kinase 1/0.446
3gu6ADPDeath-associated protein kinase 12.7.11.10.446
3r9dX6BCyclin-dependent kinase 22.7.11.220.446
3wi6YRZMAP kinase-activated protein kinase 22.7.11.10.446
4bieIE6Mitogen-activated protein kinase kinase kinase 52.7.11.250.446
4gmy0X5Tyrosine-protein kinase JAK2/0.446
4mwhATPCasein kinase II subunit alpha2.7.11.10.446
1pmv537Mitogen-activated protein kinase 102.7.11.240.445
1vjy460TGF-beta receptor type-12.7.11.300.445
2itzIREEpidermal growth factor receptor2.7.10.10.445
2ivvPP1Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.445
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.445
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.445
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.445
4hvg19QTyrosine-protein kinase JAK32.7.10.20.445
4yuqKS1Calmodulin-like domain protein kinase/0.445
1s60COAAminoglycoside N(6')-acetyltransferase type 1/0.444
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.444
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.444
3lj3WYEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
3rk507ZCyclin-dependent kinase 22.7.11.220.444
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.444
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.444
1u54ACPActivated CDC42 kinase 1/0.443
2acxANPG protein-coupled receptor kinase 62.7.11.160.443
2e9v85ASerine/threonine-protein kinase Chk12.7.11.10.443
4fv7E94Mitogen-activated protein kinase 12.7.11.240.443
2qblCAMCamphor 5-monooxygenase1.14.15.10.442
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.442
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.442
3w2cN15Aurora kinase A2.7.11.10.442
4gii0X6Non-receptor tyrosine-protein kinase TYK22.7.10.20.442
4krcAGSCyclin-dependent protein kinase PHO852.7.11.220.442
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.441
3irm1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.441
3uozFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.441
2znnS44Peroxisome proliferator-activated receptor alpha/0.440
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.440
4hvh19RTyrosine-protein kinase JAK32.7.10.20.440