Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4c4g7RODual specificity protein kinase TTK2.7.12.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4c4g7RODual specificity protein kinase TTK2.7.12.11.000
4bi1ZO6Dual specificity protein kinase TTK2.7.12.10.677
4bi0Z0WDual specificity protein kinase TTK2.7.12.10.667
4c4iX20Dual specificity protein kinase TTK2.7.12.10.648
4c4f7CEDual specificity protein kinase TTK2.7.12.10.626
4c4h7RODual specificity protein kinase TTK2.7.12.10.624
5ap57RODual specificity protein kinase TTK2.7.12.10.569
2zmd537Dual specificity protein kinase TTK2.7.12.10.563
5ap7SVEDual specificity protein kinase TTK2.7.12.10.514
2o2u738Mitogen-activated protein kinase 102.7.11.240.483
2vu3LZECyclin-dependent kinase 22.7.11.220.476
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.470
3axwTIDCasein kinase II subunit alpha2.7.11.10.469
4b99R4LMitogen-activated protein kinase 72.7.11.240.466
2c6eHPMAurora kinase A2.7.11.10.462
2w05FRTCyclin-dependent kinase 22.7.11.220.461
4fv9E71Mitogen-activated protein kinase 12.7.11.240.461
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.460
3vquO22Dual specificity protein kinase TTK2.7.12.10.459
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.456
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.455
3k5uPFQAurora kinase A2.7.11.10.454
4id71G0Activated CDC42 kinase 1/0.453
2fvdLIACyclin-dependent kinase 22.7.11.220.452
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.452
3t8oATPRhodopsin kinase/0.452
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.452
3at4CCKCasein kinase II subunit alpha2.7.11.10.450
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.450
4o0uADNAurora kinase A2.7.11.10.448
4jia1K3Tyrosine-protein kinase JAK2/0.447
2wqeADPAurora kinase A2.7.11.10.445
3w1f1O5Dual specificity protein kinase TTK2.7.12.10.445
2ckeIQUDeath-associated protein kinase 2/0.443
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.443
4qmlANPSerine/threonine-protein kinase 242.7.11.10.442
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.441
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.440
4ic7ANPMitogen-activated protein kinase 72.7.11.240.440