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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3zze6XPHepatocyte growth factor receptor2.7.10.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3zze6XPHepatocyte growth factor receptor2.7.10.11.000
4gg70J8Hepatocyte growth factor receptor2.7.10.10.625
2wgjVGHHepatocyte growth factor receptor2.7.10.10.602
3a4pDFQHepatocyte growth factor receptor2.7.10.10.589
4ap7F47Hepatocyte growth factor receptor2.7.10.10.573
4deg0JJHepatocyte growth factor receptor2.7.10.10.550
3zxzKRWHepatocyte growth factor receptor2.7.10.10.530
4aoi4K0Hepatocyte growth factor receptor2.7.10.10.512
3zc5W9ZHepatocyte growth factor receptor2.7.10.10.509
4gg50J3Hepatocyte growth factor receptor2.7.10.10.505
4kb81QOCasein kinase I isoform delta2.7.11.10.470
2jedLG8Protein kinase C theta type2.7.11.130.466
4i22IREEpidermal growth factor receptor2.7.10.10.464
2b7aIZATyrosine-protein kinase JAK2/0.462
3lqfNADGalactitol dehydrogenase/0.457
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.455
2xikJ60Serine/threonine-protein kinase 252.7.11.10.455
4c02TAKActivin receptor type-12.7.11.300.453
5cwa0GAAnthranilate synthase component 14.1.3.270.452
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.451
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.451
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.449
5e8wSTUTGF-beta receptor type-12.7.11.300.449
2zjwREFCasein kinase II subunit alpha2.7.11.10.447
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.447
5c8d5ADProbable transcriptional regulator/0.447
3js2VM1Fibroblast growth factor receptor 1/0.446
4wboANWRhodopsin kinase/0.446
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.10.445
1eh4IC1Casein kinase I homolog 12.7.11.10.444
3nxe2NCProtease/0.444
4gu610NFocal adhesion kinase 12.7.10.20.444
1q1rFADPutidaredoxin reductase1.18.1.50.443
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.442
3zh8C58Protein kinase C iota type2.7.11.130.442
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.441
3uyt0CKCasein kinase I isoform delta2.7.11.10.441
4dymIYZActivin receptor type-12.7.11.300.441
1rekB8LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
3nwq2NCGag-Pol polyprotein3.4.23.160.440
3nwxKVSGag-Pol polyprotein3.4.23.160.440
4f650S9Fibroblast growth factor receptor 1/0.440